ENSMUSG00000074768


Mus musculus

Features
Gene ID: ENSMUSG00000074768
  
Biological name :Bhmt
  
Synonyms : Betaine--homocysteine S-methyltransferase 1 / Bhmt / O35490
  
Possible biological names infered from orthology : betaine--homocysteine S-methyltransferase / Q93088
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: C3
Gene start: 93616675
Gene end: 93637961
  
Corresponding Affymetrix probe sets: 10411142 (MoGene1.0st)   10457114 (MoGene1.0st)   10511886 (MoGene1.0st)   1450624_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000096912
NCBI entrez gene - 12116     See in Manteia.
MGI - MGI:1339972
RefSeq - NM_016668
RefSeq Peptide - NP_057877
swissprot - O35490
Ensembl - ENSMUSG00000074768
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bhmtENSDARG00000013430Danio rerio
 ENSGALG00000004518Gallus gallus
 BHMTENSG00000145692Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm5096 / O35490 / predicted gene 5096 / BHMT* / Q93088* / betaine--homocysteine S-methyltransferase*ENSMUSG00000069324100
Bhmt2 / Q91WS4 / S-methylmethionine--homocysteine S-methyltransferase BHMT2 / Q9H2M3* / betaine--homocysteine S-methyltransferase 2*ENSMUSG0000004211867


Protein motifs (from Interpro)
Interpro ID Name
 IPR003726  Homocysteine-binding domain
 IPR017226  Betaine-homocysteine S-methyltransferase, BHMT
 IPR036589  Homocysteine-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006577 amino-acid betaine metabolic process ISO
 biological_processGO:0006579 amino-acid betaine catabolic process IEA
 biological_processGO:0009086 methionine biosynthetic process IDA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0071267 L-methionine salvage ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0070062 extracellular exosome ISO
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008270 zinc ion binding ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047150 betaine-homocysteine S-methyltransferase activity ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0003324 liver adenoma "benign epithelial neoplasm of the liver" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Pofut2tm2.2Bch/Pofut2tm2.2Bch
Genetic Background: B6.Cg-Pofut2tm2.2Bch

 MP:0003949 abnormal circulating lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Pofut2tm2.2Bch/Pofut2tm2.2Bch
Genetic Background: B6.Cg-Pofut2tm2.2Bch

 MP:0003981 decreased circulating phospholipid level "reduced concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0004777 abnormal phospholipid level "anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf11tm1.2Htaka/Tnfsf11+
Genetic Background: B6.Cg-Tnfsf11tm1.2Htaka

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pofut2tm2.2Bch/Pofut2tm2.2Bch
Genetic Background: B6.Cg-Pofut2tm2.2Bch

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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