Manteia - Molecule gene

ENSMUSG00000075324

Mus musculus

Features

Gene ID:	ENSMUSG00000075324

Biological name :	Fign

Synonyms :	Fidgetin / Fign / Q9ERZ6

Possible biological names infered from orthology :	fidgetin, microtubule severing factor / Q5HY92

Species:	Mus musculus

Chr. number:	2
Strand:	-1
Band:	C1.3
Gene start:	63971507
Gene end:	64098038

Corresponding Affymetrix probe sets:	10483150 (MoGene1.0st) 1439602_at (Mouse Genome 430 2.0 Array) 1442873_at (Mouse Genome 430 2.0 Array) 1450268_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000122855 Ensembl peptide - ENSMUSP00000124338 NCBI entrez gene - 60344 See in Manteia. MGI - MGI:1890647 RefSeq - NM_001267846 RefSeq - NM_021716 RefSeq Peptide - NP_001254775 RefSeq Peptide - NP_068362 swissprot - Q9ERZ6 swissprot - E0CYB7 Ensembl - ENSMUSG00000075324

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
fign	ENSDARG00000008662	Danio rerio
FIGN	ENSGALG00000011069	Gallus gallus
FIGN	ENSG00000182263	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Fignl2 / fidgetin like 2 / A6NMB9*	ENSMUSG00000095440	36
Fignl1 / Q8BPY9 / Fidgetin-like protein 1 / Q6PIW4* / fidgetin like 1*	ENSMUSG00000035455	33
Spast / Q9QYY8 / Spastin / Q9UBP0*	ENSMUSG00000024068	20
A6H690 / 4931409K22Rik / IQ and AAA domain-containing protein 1-like / IQCA1L* / IQ motif containing with AAA domain 1 like*	ENSMUSG00000038199	14
Iqca / Q9CUL5 / IQ and AAA domain-containing protein 1 / IQCA1* / Q86XH1* / IQ motif containing with AAA domain 1*	ENSMUSG00000026301	14

Protein motifs (from Interpro)

Interpro ID	Name
IPR003593	AAA+ ATPase domain
IPR003959	ATPase, AAA-type, core
IPR003960	ATPase, AAA-type, conserved site
IPR015415	Vps4 oligomerisation, C-terminal
IPR027417	P-loop containing nucleoside triphosphate hydrolase

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007049	cell cycle	IEA
biological_process	GO:0010569	regulation of double-strand break repair via homologous recombination	IBA
biological_process	GO:0051301	cell division	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005815	microtubule organizing center	IEA
cellular_component	GO:0005856	cytoskeleton	IEA
cellular_component	GO:0005874	microtubule	IEA
cellular_component	GO:0016363	nuclear matrix	IEA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0008022	protein C-terminus binding	IPI
molecular_function	GO:0016887	ATPase activity	IBA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000035	abnormal membranous labyrinth	"malformations in the complex arrangement of communicating canaliculi and sacs suspended within the cavity of the bony labyrinth of the inner ear" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23837]	Show Allelic Composition: Fign^fi/Fign^fi Genetic Background: mixed
MP:0000036	absent semicircular canals	"missing organ of balance; consists of three bony tubes within which the semicircular ducts are located" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]	Show Allelic Composition: Fign^fi/Fign^fi Genetic Background: mixed Allelic Composition: Fign^tm1Frk/Fign^fi Genetic Background: involves: 129S1/Sv * 129X1SvJ * C57BL/6J
MP:0000458	abnormal mandible morphology	"malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Jag2^tm1Grid/Jag2^tm1Grid,Lfng^tm1Grid/Lfng⁺ Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0000562	polydactyly	"greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Jag2^tm1Grid/Jag2^tm1Grid,Lfng^tm1Grid/Lfng⁺ Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0000929	open neural tube	"incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]	Show Allelic Composition: Fign^fi/Fign^fi,Pax3^Sp/Pax3^Sp Genetic Background: BR.Cg-Pax3^Sp Fign^fi
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Jag2^tm1Grid/Jag2^tm1Grid,Lfng^tm1Grid/Lfng⁺ Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0001297	microphthalmia	"reduced average size of the eyes" [J:18048]	Show Allelic Composition: Prkdc^scid/Prkdc^scid,Idua^tm1Clk/Idua^tm1Clk Genetic Background: NOD.129(B6)-Prkdc^scid Idua^tm1Clk/J Allelic Composition: Fign^fi/Fign^fi Genetic Background: mixed Allelic Composition: Fign^tm1Frk/Fign^fi Genetic Background: involves: 129S1/Sv * 129X1SvJ * C57BL/6J
MP:0001306	small lens	"reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Jag2^tm1Grid/Jag2^tm1Grid,Lfng^tm1Grid/Lfng⁺ Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0001312	abnormal cornea morphology	"malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Jag2^tm1Grid/Jag2^tm1Grid,Lfng^tm1Grid/Lfng⁺ Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0001314	corneal opacity	"complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Jag2^tm1Grid/Jag2^tm1Grid,Lfng^tm1Grid/Lfng⁺ Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0001347	absent lacrimal glands	"missing the glands that secrete tears" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Jag2^tm1Grid/Jag2^tm1Grid,Lfng^tm1Grid/Lfng⁺ Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0001386	abnormal maternal nurturing	"failure of mothers to tend offspring" [J:39801]	Show Allelic Composition: Jag2^tm1Grid/Jag2^tm1Grid,Lfng^tm1Grid/Lfng⁺ Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0001395	bi-directional circling	"circling behavior exhibited in both clockwise and counterclockwise directions" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Fign^fi/Fign^fi Genetic Background: mixed
MP:0001405	impaired coordination	"reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Jag2^tm1Grid/Jag2^tm1Grid,Lfng^tm1Grid/Lfng⁺ Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0001488	increased startle reflex	"reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Jag2^tm1Grid/Jag2^tm1Grid,Lfng^tm1Grid/Lfng⁺ Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0001575	cyanosis	"a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]	Show Allelic Composition: Gata3^tm2Gsv/Gata3⁺ Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fign^fi/Fign^fi Genetic Background: mixed
MP:0001851	eye inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the eye" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fign^fi/Fign^fi Genetic Background: mixed
MP:0001852	conjunctivitis	"inflammation of the mucous membrane that lines the inner surface of the eyelids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]	Show Allelic Composition: Fign^fi/Fign^fi Genetic Background: mixed
MP:0001921	reduced fertility	"diminished ability to produce live offspring" [J:65030]	Show Allelic Composition: Jag2^tm1Grid/Jag2^tm1Grid,Lfng^tm1Grid/Lfng⁺ Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0001954	respiratory distress	"physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Gata3^tm2Gsv/Gata3⁺ Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)
MP:0001967	deafness	"inability to hear" [J:57651]	Show Allelic Composition: Fign^fi/Fign^fi Genetic Background: mixed
MP:0002116	abnormal craniofacial bone morphology	"abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Jag2^tm1Grid/Jag2^tm1Grid,Lfng^tm1Grid/Lfng⁺ Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0002428	abnormal semicircular canal	"anomaly of the organ of balance composed of three long bony tubes of the labyrinth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fign^tm1Frk/Fign^fi Genetic Background: involves: 129S1/Sv * 129X1SvJ * C57BL/6J
MP:0002730	head shaking	"compulsive movement of the head in the horizontal plane" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:274]	Show Allelic Composition: Prkdc^scid/Prkdc^scid,Idua^tm1Clk/Idua^tm1Clk Genetic Background: NOD.129(B6)-Prkdc^scid Idua^tm1Clk/J Allelic Composition: Fign^fi/Fign^fi Genetic Background: mixed Allelic Composition: Fign^tm1Frk/Fign^fi Genetic Background: involves: 129S1/Sv * 129X1SvJ * C57BL/6J
MP:0003077	abnormal cell cycle	"failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]	Show Allelic Composition: Fign^fi/Fign^fi Genetic Background: mixed
MP:0003161	absent lateral semicircular canal		Show Allelic Composition: Fign^fi/Fign^fi Genetic Background: mixed
MP:0003312	abnormal locomotor coordination	"reduced ability of an animal to maintain skillful and effective interaction of movements while engaging in locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fign^fi/Fign^fi Genetic Background: mixed
MP:0004045	abnormal cell cycle checkpoint function	"anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^tm1(GRN)Pvd/Gt(ROSA)26Sor^tm1(GRN)Pvd,Tg(Pgk1-cre)1Lni/0,Tg(SOD1G93A)1Gur/0 Genetic Background:* B6J.Cg-Tg(Pgk1-cre)1Lni Gt(ROSA)26Sor^tm1(GRN)Pvd Tg(SOD1*G93A)1Gur
MP:0004509	abnormal pelvic girdle bone morphology	"any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fign^fi/Fign^fi Genetic Background: mixed
MP:0004748	increased susceptibility to age-related hearing loss	"greater than normal loss of hearing associated with advancing age, manifest as reduced ability to perceive or discriminate sounds; the pattern and age of onset vary" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fign^fi/Fign^fi Genetic Background: mixed
MP:0005542	corneal vascularization	"formation of blood vessels in the cornea, which normally lacks vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Fign^fi/Fign^fi Genetic Background: mixed
MP:0006071	abnormal retinal progenitor morphology	"anomoly in the proliferation or differentiation of the cells that give rise to the various cells of the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92622:]	Show Allelic Composition: Fign^fi/Fign^fi Genetic Background: mixed
MP:0006097	abnormal cerebellar lobule formation	"anomaly in the formation of the lobes of the cerebellum" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410]	Show Allelic Composition: Fign^fi/Fign^fi Genetic Background: mixed
MP:0008919	fused tarsal bones	"anomaly of the eight bones of the instep of the paw/foot resulting in some or all the bones being joined together" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Fign^fi/Fign^fi Genetic Background: mixed
MP:0009772	abnormal retinal development	"anomaly in any of the steps during embryogenesis that produce the nerve layer lining in the back of the eye which senses light, and creates impulses that travel through the optic nerve to the brain" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fign^fi/Fign^fi Genetic Background: mixed
MP:0009890	cleft secondary palate	"congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]	Show Allelic Composition: Gata3^tm2Gsv/Gata3⁺ Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6) Allelic Composition: Akap8^Gt(XG068)Byg/Akap8⁺,Fign^fi/Fign^fi Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6 Allelic Composition: Akap8^Gt(XG068)Byg/Akap8^Gt(XG068)Byg,Fign^fi/Fign⁺ Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6 Allelic Composition: Fign^fi/Fign^fi Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6 Allelic Composition: Fign^fi/Fign^fi Genetic Background: involves: 129S1/SvImJ * C57BL/6
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Gata3^tm2Gsv/Gata3⁺ Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Prkdc^scid/Prkdc^scid,Idua^tm1Clk/Idua^tm1Clk Genetic Background: NOD.129(B6)-Prkdc^scid Idua^tm1Clk/J
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Gata3^tm2Gsv/Gata3⁺ Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S7/SvEvBrd * C57BL/6)
MP:0011091	complete prenatal lethality	"death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Fign^fi/Fign^fi,Pax3^Sp/Pax3^Sp Genetic Background: BR.Cg-Pax3^Sp Fign^fi
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Prkdc^scid/Prkdc^scid,Idua^tm1Clk/Idua^tm1Clk Genetic Background: NOD.129(B6)-Prkdc^scid Idua^tm1Clk/J
MP:0013387	Meibomian gland hypertrophy	"increase in the bulk size of the meibum-secreting modified lobulated sebaceous glands located at the rim of the eyelids inside the tarsal plate due to cell enlargement" [MGI:Anna]	Show Allelic Composition: Fign^fi/Fign^fi Genetic Background: mixed
MP:0013447	Harderian gland hypertrophy	"increase in the bulk size, due to cell enlargement, of the sebaceous gland that is located behind the eyeball and excretes fluid that facilitates movement of the nictitating membrane" [MGI:Anna]	Show Allelic Composition: Fign^fi/Fign^fi Genetic Background: mixed
MP:0030233	absent mandibular canal	"absence of the canal that is normally located within the internal aspect of the mandible and contains the inferior alveolar nerve, artery and the vein" [MGI:anna]	Show Allelic Composition: Fign^fi/Fign^fi Genetic Background: mixed
MP:0030235	absent mandibular foramen	"absence of the opening that is normally located on the medial surface of the ramus of the mandible and forms the entrance to the mandibular canal" [MGI:anna]	Show Allelic Composition: Fign^fi/Fign^fi Genetic Background: mixed
MP:0030237	absent mental foramen	"absence of the small opening located on the anterior surface of the mandible; normally, the mental nerve, a terminal branch of inferior alveolar nerve, and the mental artery leave the mandibular canal through it" [MGI:anna]	Show Allelic Composition: Fign^fi/Fign^fi Genetic Background: mixed

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr