ENSMUSG00000024068


Mus musculus

Features
Gene ID: ENSMUSG00000024068
  
Biological name :Spast
  
Synonyms : Q9QYY8 / Spast / Spastin
  
Possible biological names infered from orthology : Q9UBP0
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: E2
Gene start: 74338987
Gene end: 74391115
  
Corresponding Affymetrix probe sets: 10446785 (MoGene1.0st)   1454794_at (Mouse Genome 430 2.0 Array)   1460400_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153469
Ensembl peptide - ENSMUSP00000024869
Ensembl peptide - ENSMUSP00000153004
NCBI entrez gene - 50850     See in Manteia.
MGI - MGI:1858896
RefSeq - XM_011246530
RefSeq - NM_001162870
RefSeq - NM_016962
RefSeq - XM_006524610
RefSeq - XM_006524611
RefSeq Peptide - NP_058658
RefSeq Peptide - NP_001156342
swissprot - A0A286YE25
swissprot - Q9QYY8
swissprot - A0A286YCJ4
Ensembl - ENSMUSG00000024068
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spastENSDARG00000024933Danio rerio
 SPASTENSGALG00000010620Gallus gallus
 SPASTENSG00000021574Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fignl1 / Q8BPY9 / Fidgetin-like protein 1 / Q6PIW4* / fidgetin like 1*ENSMUSG0000003545532
Fign / Q9ERZ6 / Fidgetin / Q5HY92* / fidgetin, microtubule severing factor*ENSMUSG0000007532425
Fignl2 / fidgetin like 2 / A6NMB9*ENSMUSG0000009544022
A6H690 / 4931409K22Rik / IQ and AAA domain-containing protein 1-like / IQCA1L* / IQ motif containing with AAA domain 1 like*ENSMUSG0000003819919
Iqca / Q9CUL5 / IQ and AAA domain-containing protein 1 / IQCA1* / Q86XH1* / IQ motif containing with AAA domain 1*ENSMUSG0000002630118


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR003960  ATPase, AAA-type, conserved site
 IPR007330  MIT
 IPR015415  Vps4 oligomerisation, C-terminal
 IPR017179  Spastin
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035106  Spastin, chordate


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000281 mitotic cytokinesis IEA
 biological_processGO:0001578 microtubule bundle formation IEA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0008089 anterograde axonal transport IMP
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0010458 exit from mitosis IEA
 biological_processGO:0019896 axonal transport of mitochondrion IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031117 positive regulation of microtubule depolymerization IEA
 biological_processGO:0031468 nuclear envelope reassembly IEA
 biological_processGO:0032467 positive regulation of cytokinesis IEA
 biological_processGO:0032506 cytokinetic process IEA
 biological_processGO:0034214 protein hexamerization IEA
 biological_processGO:0051013 microtubule severing IEA
 biological_processGO:0051228 mitotic spindle disassembly IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0090148 membrane fission IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome ISS
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005811 lipid droplet IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030496 midbody ISO
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031965 nuclear membrane ISS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0071782 endoplasmic reticulum tubular network ISO
 cellular_componentGO:1904115 axon cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008568 microtubule-severing ATPase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity IBA
 molecular_functionGO:0043014 alpha-tubulin binding IEA
 molecular_functionGO:0048487 beta-tubulin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Elovl4tm3Kzh/Elovl4tm3Kzh,Tg(Rho-icre)1Ck/?
Genetic Background: involves: C57BL/6 * SJL

Allelic Composition: Spasttm1Jfnk/Spast+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Prkntm1Ykt/Prkntm1Ykt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: SpastM1Gri/SpastM1Gri
Genetic Background: B6.C-SpastM1Gri

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
Show

Allelic Composition: Prkntm1Ykt/Prkntm1Ykt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: Prkntm1Ykt/Prkntm1Ykt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkntm1Ykt/Prkntm1Ykt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004768 abnormal axonal transport "any functional anomaly of the directed movement of organelles or vesicles along microtubules in nerve cell axons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: SpastM1Gri/SpastM1Gri
Genetic Background: B6.C-SpastM1Gri

Allelic Composition: SpastM1Gri/Spast+
Genetic Background: B6.C-SpastM1Gri

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkntm1Ykt/Prkntm1Ykt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Spasttm1.1Jme/Spast+
Genetic Background: involves: C57BL/6J

Allelic Composition: SpastM1Gri/SpastM1Gri
Genetic Background: B6.C-SpastM1Gri

Allelic Composition: SpastM1Gri/Spast+
Genetic Background: B6.C-SpastM1Gri

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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