ENSDARG00000009021


Danio rerio

Features
Gene ID: ENSDARG00000009021
  
Biological name :chrna1
  
Synonyms : cholinergic receptor, nicotinic, alpha 1 (muscle) / chrna1 / Q98880
  
Possible biological names infered from orthology : cholinergic receptor nicotinic alpha 1 subunit / cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) / P02708 / P04756
  
Species: Danio rerio
  
Chr. number: 6
Strand: -1
Band:
Gene start: 10812337
Gene end: 10828923
  
Corresponding Affymetrix probe sets: Dr.123.1.S1_at (Zebrafish Array)   NM_131445_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000113165
Ensembl peptide - ENSDARP00000021860
NCBI entrez gene - 30725     See in Manteia.
RefSeq - NM_131445
RefSeq Peptide - NP_571520
swissprot - E9QGW8
swissprot - Q98880
ZFIN ID - ZDB-GENE-980526-137
Ensembl - ENSDARG00000009021
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CHRNA1ENSGALG00000009301Gallus gallus
 CHRNA1ENSG00000138435Homo sapiens
 Chrna1ENSMUSG00000027107Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
chrna2b / cholinergic receptor, nicotinic, alpha 2b (neuronal) / CHRNA2* / Q15822* / Q91X60* / cholinergic receptor nicotinic alpha 2 subunit* / cholinergic receptor, nicotinic, alpha polyp...ENSDARG0000005702548
chrna3 / cholinergic receptor, nicotinic, alpha 3 / P32297* / cholinergic receptor nicotinic alpha 3 subunit* / cholinergic receptor, nicotinic, alpha polypeptide 3*ENSDARG0000010099148
chrna2a / cholinergic receptor, nicotinic, alpha 2a (neuronal) / CHRNA2* / Q15822* / Q91X60* / cholinergic receptor nicotinic alpha 2 subunit* / cholinergic receptor, nicotinic, alpha polyp...ENSDARG0000000660247
chrna4b / cholinergic receptor, nicotinic, alpha 4b / CHRNA4* / O70174* / P43681* / cholinergic receptor nicotinic alpha 4 subunit* / cholinergic receptor, nicotinic, alpha polypeptide 4*ENSDARG0000007072447
chrna6 / cholinergic receptor, nicotinic, alpha 6 / Q15825* / Q9R0W9* / cholinergic receptor nicotinic alpha 6 subunit* / cholinergic receptor, nicotinic, alpha polypeptide 6*ENSDARG0000005555946
chrna4a / cholinergic receptor, nicotinic, alpha 4a / CHRNA4* / O70174* / P43681* / cholinergic receptor nicotinic alpha 4 subunit* / cholinergic receptor, nicotinic, alpha polypeptide 4*ENSDARG0000008707144
chrnb3b / cholinergic receptor, nicotinic, beta 3b (neuronal) / CHRNB3* / Q05901* / Q8BMN3* / cholinergic receptor nicotinic beta 3 subunit* / cholinergic receptor, nicotinic, beta polypeptide 3*ENSDARG0000003850841
chrnb3a / cholinergic receptor, nicotinic, beta polypeptide 3a / Q8BMN3* / CHRNB3* / Q05901* / cholinergic receptor nicotinic beta 3 subunit* / cholinergic receptor, nicotinic, beta polypeptide 3*ENSDARG0000005276441
chrnb4 / cholinergic receptor, nicotinic, beta 4 (neuronal) / P30926* / Q8R493* / cholinergic receptor nicotinic beta 4 subunit* / cholinergic receptor, nicotinic, beta polypeptide 4*ENSDARG0000010167741
chrnb2a / cholinergic receptor, nicotinic, beta 2aENSDARG0000011577841
chrna5 / cholinergic receptor, nicotinic, alpha 5 / P30532* / Q2MKA5* / cholinergic receptor nicotinic alpha 5 subunit* / cholinergic receptor, nicotinic, alpha polypeptide 5*ENSDARG0000000342040
chrnb2b / cholinergic receptor, nicotinic, beta 2b / CHRNB2* / P17787* / Q9ERK7* / cholinergic receptor nicotinic beta 2 subunit* / cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)*ENSDARG0000001779040
chrnb2l / cholinergic receptor, nicotinic, beta 2, likeENSDARG0000002139238


Protein motifs (from Interpro)
Interpro ID Name
 IPR002394  Nicotinic acetylcholine receptor
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR018000  Neurotransmitter-gated ion-channel, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003428 chondrocyte intercalation involved in growth plate cartilage morphogenesis IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007271 synaptic transmission, cholinergic IDA
 biological_processGO:0007274 neuromuscular synaptic transmission IDA
 biological_processGO:0008045 motor neuron axon guidance IMP
 biological_processGO:0030516 regulation of axon extension IMP
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035094 response to nicotine IBA
 biological_processGO:0043113 receptor clustering IMP
 biological_processGO:0048705 skeletal system morphogenesis IMP
 biological_processGO:0048741 skeletal muscle fiber development IMP
 biological_processGO:0060078 regulation of postsynaptic membrane potential IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0086009 membrane repolarization IMP
 biological_processGO:0098655 cation transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005892 acetylcholine-gated channel complex IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005261 cation channel activity IDA
 molecular_functionGO:0015464 acetylcholine receptor activity IDA
 molecular_functionGO:0022848 acetylcholine-gated cation-selective channel activity IEA
 molecular_functionGO:0042166 acetylcholine binding IMP


Pathways (from Reactome)
Pathway description
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly calcium permeable nicotinic acetylcholine receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton quality , abnormal
pharyngeal arch 3-7 skeleton morphology , abnormal
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 ZFA:0000135 notochord notochord dorsal-ventral axis increased size , abnormal
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 ZFA:0000473 trunk musculature trunk musculature quality , abnormal
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 ZFA:0000547 mouth mouth quality , abnormal
mouth morphology , abnormal
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 ZFA:0001056 myotome myotome dorsal-ventral axis increased size , abnormal
myotome increased size , abnormal
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 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
whole organism immobile , abnormal
whole organism paralysed , abnormal
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 ZFA:0001117 post-vent region post-vent region curved dorsal , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage decreased length , abnormal
ceratohyal cartilage chondrocyte morphology , abnormal
ceratohyal cartilage chondrocyte decreased size , abnormal
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 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage morphology , abnormal
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 ZFA:0005145 muscle muscle degenerate , abnormal
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 ZFA:0005277 skeletal muscle skeletal muscle skeletal muscle myofibril organization quality , abnormal
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 ZFA:0009053 sensory neuron sensory neuron morphology , abnormal
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 ZFA:0009084 chondrocyte chondrocyte stacked , abnormal
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 ZFA:0009114 muscle cell muscle cell increased permeability , abnormal
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 ZFA:0009115 skeletal muscle cell skeletal muscle cell Z disc spatial pattern , abnormal
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 ZFA:0009150 Rohon-Beard neuron Rohon-Beard neuron dendrite decreased length , abnormal
Rohon-Beard neuron morphology , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000009021 Q98880 / chrna1 / cholinergic receptor, nicotinic, alpha 1 (muscle) / P02708* / P04756* / cholinergic receptor nicotinic alpha 1 subunit* / cholinergic receptor, nicotinic, alpha polypeptid...  / complex






 

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