ENSDARG00000010246


Danio rerio

Features
Gene ID: ENSDARG00000010246
  
Biological name :prmt1
  
Synonyms : prmt1 / protein arginine methyltransferase 1
  
Possible biological names infered from orthology : protein arginine N-methyltransferase 1 / Q99873 / Q9JIF0
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 32356833
Gene end: 32363021
  
Corresponding Affymetrix probe sets: Dr.879.1.S1_at (Zebrafish Array)   NM_200650_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000039367
Ensembl peptide - ENSDARP00000010384
NCBI entrez gene - 321974     See in Manteia.
RefSeq - NM_200650
RefSeq Peptide - NP_956944
swissprot - F1R3J9
swissprot - F1QFJ1
ZFIN ID - ZDB-GENE-030131-693
Ensembl - ENSDARG00000010246
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRMT1ENSG00000126457Homo sapiens
 Prmt1ENSMUSG00000109324Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRMT8 / protein arginine methyltransferase 8 / Q9NR22*ENSDARG0000004063377
Q5RGQ2 / prmt8b / protein arginine methyltransferase 8b / PRMT8* / Q6PAK3* / Q9NR22* / protein arginine methyltransferase 8* / protein arginine N-methyltransferase 8*ENSDARG0000004576075
prmt3 / protein arginine methyltransferase 3 / O60678* / Q922H1* / protein arginine N-methyltransferase 3*ENSDARG0000001979145
prmt6 / protein arginine methyltransferase 6 / Q96LA8*ENSDARG0000006970640
carm1 / Q6DC04 / coactivator-associated arginine methyltransferase 1 / Q9WVG6* / Q86X55* / Histone-arginine methyltransferase CARM1 *ENSDARG0000001869836
carm1l / coactivator-associated arginine methyltransferase 1, likeENSDARG0000009153132
prmt2 / protein arginine methyltransferase 2 / P55345* / protein arginine N-methyltransferase 2*ENSDARG0000006321231


Protein motifs (from Interpro)
Interpro ID Name
 IPR025799  Protein arginine N-methyltransferase
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IBA
 biological_processGO:0006479 protein methylation IEA
 biological_processGO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0043985 histone H4-R3 methylation IMP
 biological_processGO:0060027 convergent extension involved in gastrulation IMP
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008469 histone-arginine N-methyltransferase activity IBA
 molecular_functionGO:0008757 S-adenosylmethionine-dependent methyltransferase activity ISS
 molecular_functionGO:0016273 arginine N-methyltransferase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035242 protein-arginine omega-N asymmetric methyltransferase activity IBA


Pathways (from Reactome)
Pathway description
RMTs methylate histone arginines
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000084 yolk yolk increased size , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000114 heart heart edematous , abnormal
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 ZFA:0001094 whole organism whole organism broken , abnormal
whole organism anterior-posterior axis decreased length , abnormal
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 ZFA:0001117 post-vent region post-vent region curved , abnormal
post-vent region truncated , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000018257 ncoa1 / nuclear receptor coactivator 1 / P70365* / Q15788*  / complex / reaction
 ENSDARG00000077404 ncoa3 / nuclear receptor coactivator 3 / Q9Y6Q9*  / complex / reaction
 ENSDARG00000087646 runx1 / runt-related transcription factor 1 / Q01196*  / complex / reaction
 ENSDARG00000004111 esr1 / estrogen receptor 1 / P03372* / P19785* / Estrogen receptor *  / complex / reaction
 ENSDARG00000014994 tbp / Q7SXL3 / TATA box binding protein / P20226* / P29037*  / complex / reaction
 ENSDARG00000016526 gata3 / Q91428 / GATA binding protein 3 / P23771* / P23772* / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA.*  / complex / reaction
 ENSDARG00000053685 gtf2a2 / general transcription factor IIA, 2 / P52657* / Q80ZM7* / general transcription factor IIA subunit 2* / Transcription initiation factor IIA subunit 2 *  / complex / reaction






 

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