ENSDARG00000018698


Danio rerio

Features
Gene ID: ENSDARG00000018698
  
Biological name :carm1
  
Synonyms : carm1 / coactivator-associated arginine methyltransferase 1 / Q6DC04
  
Possible biological names infered from orthology : Histone-arginine methyltransferase CARM1 / Q86X55 / Q9WVG6
  
Species: Danio rerio
  
Chr. number: 3
Strand: 1
Band:
Gene start: 34149337
Gene end: 34172214
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000125959
Ensembl peptide - ENSDARP00000126308
Ensembl peptide - ENSDARP00000016959
NCBI entrez gene - 445251     See in Manteia.
RefSeq - XM_005164016
RefSeq Peptide - NP_001003645
swissprot - I3ITN7
swissprot - I3ISR8
swissprot - Q6DC04
ZFIN ID - ZDB-GENE-040724-77
Ensembl - ENSDARG00000018698
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CARM1ENSG00000142453Homo sapiens
 Carm1ENSMUSG00000032185Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
carm1l / coactivator-associated arginine methyltransferase 1, likeENSDARG0000009153147
prmt1 / protein arginine methyltransferase 1 / Q99873* / Q9JIF0* / protein arginine N-methyltransferase 1*ENSDARG0000001024621
prmt3 / protein arginine methyltransferase 3 / O60678* / Q922H1* / protein arginine N-methyltransferase 3*ENSDARG0000001979121
PRMT8 / protein arginine methyltransferase 8 / Q9NR22*ENSDARG0000004063321
Q5RGQ2 / prmt8b / protein arginine methyltransferase 8b / PRMT8* / Q6PAK3* / Q9NR22* / protein arginine methyltransferase 8* / protein arginine N-methyltransferase 8*ENSDARG0000004576021
prmt2 / protein arginine methyltransferase 2 / P55345* / protein arginine N-methyltransferase 2*ENSDARG0000006321220
prmt6 / protein arginine methyltransferase 6 / Q96LA8*ENSDARG0000006970618


Protein motifs (from Interpro)
Interpro ID Name
 IPR020989  Histone-arginine methyltransferase CARM1, N-terminal
 IPR025799  Protein arginine N-methyltransferase
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IBA
 biological_processGO:0006479 protein methylation IEA
 biological_processGO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0033146 regulation of intracellular estrogen receptor signaling pathway ISS
 biological_processGO:0034969 histone arginine methylation ISS
 biological_processGO:0034971 histone H3-R17 methylation ISS
 biological_processGO:0035246 peptidyl-arginine N-methylation IEA
 biological_processGO:0045600 positive regulation of fat cell differentiation ISS
 biological_processGO:0048742 regulation of skeletal muscle fiber development IMP
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003713 transcription coactivator activity ISS
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008469 histone-arginine N-methyltransferase activity IBA
 molecular_functionGO:0008757 S-adenosylmethionine-dependent methyltransferase activity ISS
 molecular_functionGO:0016274 protein-arginine N-methyltransferase activity ISS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity ISS
 molecular_functionGO:0035242 protein-arginine omega-N asymmetric methyltransferase activity ISS
 molecular_functionGO:0035642 histone methyltransferase activity (H3-R17 specific) ISS
 molecular_functionGO:0042054 histone methyltransferase activity ISS
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISS
 molecular_functionGO:0070577 lysine-acetylated histone binding ISS


Pathways (from Reactome)
Pathway description
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000155 somite somite circular , abnormal
somite decreased size , abnormal
somite lacks parts or has fewer parts of type fast muscle cell , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism morphology , abnormal
whole organism decreased life span , abnormal
Show

 ZFA:0009116 slow muscle cell slow muscle cell mislocalised , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000004111 esr1 / estrogen receptor 1 / P03372* / P19785* / Estrogen receptor *  / complex / reaction
 ENSDARG00000014994 tbp / Q7SXL3 / TATA box binding protein / P20226* / P29037*  / complex / reaction
 ENSDARG00000016526 gata3 / Q91428 / GATA binding protein 3 / P23771* / P23772* / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA.*  / complex / reaction
 ENSDARG00000018257 ncoa1 / nuclear receptor coactivator 1 / P70365* / Q15788*  / complex / reaction
 ENSDARG00000053685 gtf2a2 / general transcription factor IIA, 2 / P52657* / Q80ZM7* / general transcription factor IIA subunit 2* / Transcription initiation factor IIA subunit 2 *  / complex / reaction
 ENSDARG00000077404 ncoa3 / nuclear receptor coactivator 3 / Q9Y6Q9*  / complex / reaction






 

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