ENSDARG00000013250


Danio rerio

Features
Gene ID: ENSDARG00000013250
  
Biological name :tars
  
Synonyms : tars / threonyl-tRNA synthetase
  
Possible biological names infered from orthology : P26639 / Q9D0R2 / Threonine--tRNA ligase, cytoplasmic
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 44346691
Gene end: 44371177
  
Corresponding Affymetrix probe sets: Dr.2543.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000036825
NCBI entrez gene - 449661     See in Manteia.
RefSeq - NM_001122786
RefSeq - XM_021476098
RefSeq Peptide - NP_001116258
swissprot - A2BIM7
ZFIN ID - ZDB-GENE-041010-218
Ensembl - ENSDARG00000013250
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TARSENSGALG00000003288Gallus gallus
 TARSENSG00000113407Homo sapiens
 TarsENSMUSG00000022241Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tarsl2 / threonyl-tRNA synthetase-like 2 / A2RTX5* / Q8BLY2* / Probable threonine--tRNA ligase 2, cytoplasmic *ENSDARG0000009277448
LO017852.1 / TARS2* / Q9BW92* / threonyl-tRNA synthetase 2, mitochondrial*ENSDARG0000007538538
mrpl39 / mitochondrial ribosomal protein L39 / Q9JKF7* / Q9NYK5* / 39S ribosomal protein L39, mitochondrial *ENSDARG000000415709


Protein motifs (from Interpro)
Interpro ID Name
 IPR002314  Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
 IPR002320  Threonine-tRNA ligase, class IIa
 IPR004095  TGS
 IPR004154  Anticodon-binding
 IPR006195  Aminoacyl-tRNA synthetase, class II
 IPR012675  Beta-grasp domain superfamily
 IPR012676  TGS-like
 IPR012947  Threonyl/alanyl tRNA synthetase, SAD
 IPR018163  Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily
 IPR033728  Threonine-tRNA ligase catalytic core domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IMP
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0006418 tRNA aminoacylation for protein translation IEA
 biological_processGO:0006435 threonyl-tRNA aminoacylation IBA
 biological_processGO:0043039 tRNA aminoacylation IEA
 biological_processGO:1903670 regulation of sprouting angiogenesis IMP
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004812 aminoacyl-tRNA ligase activity IEA
 molecular_functionGO:0004829 threonine-tRNA ligase activity IBA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000037 anatomical structure anatomical structure increased amount , abnormal
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 ZFA:0000099 brain vasculature brain vasculature increased branchiness , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0001057 intersegmental vein intersegmental vein increased branchiness , abnormal
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 ZFA:0001094 whole organism whole organism decreased size , abnormal
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 ZFA:0001114 head head decreased size , abnormal
head increased amount , abnormal
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 ZFA:0001115 trunk trunk increased amount , abnormal
trunk decreased thickness , abnormal
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 ZFA:0001267 cranial vasculature cranial vasculature increased branchiness , abnormal
cranial vasculature angiogenesis increased occurrence , abnormal
cranial vasculature angiogenic sprout increased amount , abnormal
cranial vasculature dorsal region increased branchiness , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel absent , abnormal
intersegmental vessel malformed , abnormal
intersegmental vessel truncated , abnormal
intersegmental vessel angiogenesis process quality , abnormal
intersegmental vessel branchiness , ameliorated
intersegmental vessel increased branchiness , abnormal
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 ZFA:0005004 aortic arch aortic arch vasculature dilated , abnormal
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 ZFA:0005024 trunk vasculature trunk vasculature angiogenesis occurrence , ameliorated
trunk vasculature angiogenic sprout amount , ameliorated
trunk vasculature angiogenesis increased occurrence , abnormal
trunk vasculature angiogenic sprout increased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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