ENSDARG00000030417


Danio rerio

Features
Gene ID: ENSDARG00000030417
  
Biological name :pkd1a
  
Synonyms : pkd1a / polycystic kidney disease 1a
  
Possible biological names infered from orthology : O08852 / P98161 / PKD1 / Polycystin-1 / polycystin 1, transient receptor potential channel interacting
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 54282042
Gene end: 54425791
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000039910
swissprot - F1QIA9
ZFIN ID - ZDB-GENE-100707-1
Ensembl - ENSDARG00000030417
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PKD1ENSGALG00000005714Gallus gallus
 PKD1ENSG00000008710Homo sapiens
 Pkd1ENSMUSG00000032855Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pkd1b / polycystic kidney disease 1bENSDARG0000003302924
pkd1l2a / polycystic kidney disease 1 like 2a / Pkd1l2*ENSDARG000001053449
pkd1l2b / polycystic kidney disease 1 like 2b / Pkd1l2*ENSDARG000001012148
pkd2 / Q6IVV8 / polycystic kidney disease 2 / Q13563* / O35245* / Polycystin-2 * / polycystin 2, transient receptor potential cation channel*ENSDARG000000140983
pkd1l2b / polycystic kidney disease 1 like 2b / Pkd1l2*ENSDARG000000881213
pkd2l1 / polycystic kidney disease 2-like 1 / A2A259* / Q9P0L9* / Polycystic kidney disease 2-like 1 protein * / polycystin 2 like 1, transient receptor potential cation channel*ENSDARG000000225032


Protein motifs (from Interpro)
Interpro ID Name
 IPR000203  GPS motif
 IPR000434  Polycystic kidney disease type 1 protein
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR000601  PKD domain
 IPR001024  PLAT/LH2 domain
 IPR001304  C-type lectin-like
 IPR002859  PKD/REJ-like domain
 IPR002889  Carbohydrate-binding WSC
 IPR013122  Polycystin cation channel, PKD1/PKD2
 IPR013783  Immunoglobulin-like fold
 IPR014010  REJ domain
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR022409  PKD/Chitinase domain
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0001889 liver development IMP
 biological_processGO:0001946 lymphangiogenesis IMP
 biological_processGO:0032965 regulation of collagen biosynthetic process IGI
 biological_processGO:0050982 detection of mechanical stimulus IBA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0016020 membrane IBA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005262 calcium channel activity IBA


Pathways (from Reactome)
Pathway description
VxPx cargo-targeting to cilium


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain hydrocephalic , abnormal
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 ZFA:0000114 heart heart edematous , abnormal
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 ZFA:0000123 liver liver cystic , abnormal
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 ZFA:0000151 pronephros pronephros cystic , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved dorsal , abnormal
post-vent region kinked , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton malformed , abnormal
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 ZFA:0005110 thoracic duct thoracic duct absent , abnormal
thoracic duct malformed , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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