ENSDARG00000031316


Danio rerio

Features
Gene ID: ENSDARG00000031316
  
Biological name :six6b
  
Synonyms : six6b / SIX homeobox 6b
  
Possible biological names infered from orthology : O95475 / Q9QZ28 / sine oculis-related homeobox 6 / SIX6 / SIX homeobox 6
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 20531002
Gene end: 20533865
  
Corresponding Affymetrix probe sets: Dr.11125.1.A1_at (Zebrafish Array)   NM_001020585_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000110487
NCBI entrez gene - 553611     See in Manteia.
RefSeq - NM_001020585
RefSeq Peptide - NP_001018421
swissprot - Q5TYZ2
ZFIN ID - ZDB-GENE-050522-308
Ensembl - ENSDARG00000031316
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SIX6ENSGALG00000020359Gallus gallus
 SIX6ENSG00000184302Homo sapiens
 Six6ENSMUSG00000021099Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
six6a / SIX homeobox 6a / SIX6* / Q9QZ28* / O95475* / SIX homeobox 6* / sine oculis-related homeobox 6*ENSDARG0000002518792
six3a / SIX homeobox 3a / SIX3* / Q62233* / O95343* / SIX homeobox 3* / Homeobox protein SIX3 *ENSDARG0000005800880
six3b / SIX homeobox 3b / SIX3* / Q62233* / O95343* / SIX homeobox 3* / Homeobox protein SIX3 *ENSDARG0000005487976
six7 / SIX homeobox 7ENSDARG0000007010770
six2a / SIX homeobox 2a / SIX2* / Q9NPC8* / Q62232* / SIX homeobox 2* / Homeobox protein SIX2 *ENSDARG0000005800457
six1b / Q6NZ04 / SIX homeobox 1b / SIX1* / Q62231* / Q15475* / SIX homeobox 1* / Homeobox protein SIX1 *ENSDARG0000002647355
six1a / Q6DHF9 / SIX homeobox 1a / SIX1* / Q62231* / Q15475* / SIX homeobox 1* / Homeobox protein SIX1 *ENSDARG0000003930454
six2b / SIX homeobox 2b / SIX2* / Q9NPC8* / Q62232* / SIX homeobox 2* / Homeobox protein SIX2 *ENSDARG0000005487854
six4b / SIX homeobox 4b / SIX4* / Q9UIU6* / Q61321* / SIX homeobox 4* / Homeobox protein SIX4 *ENSDARG0000003198349
six4a / SIX homeobox 4a / SIX4* / Q9UIU6* / Q61321* / SIX homeobox 4* / Homeobox protein SIX4 *ENSDARG0000000469548
six9 / SIX homeobox 9ENSDARG0000006840747
six5 / SIX homeobox 5 / P70178* / Q8N196* / Homeobox protein SIX5 *ENSDARG0000006840642


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR031701  Homeobox protein SIX1, N-terminal SD domain
 IPR032947  Homeobox protein SIX6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001654 eye development IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0035736 cell proliferation involved in compound eye morphogenesis IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000035 lens lens immature , abnormal
lens cellularity , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
eye hypoplastic , abnormal
eye immature , abnormal
eye increased amount , abnormal
Show

 ZFA:0000152 retina retina proliferative , abnormal
retina cell proliferation process quality , abnormal
Show

 ZFA:0000435 cranial nerve II cranial nerve II decreased thickness , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased pigmentation , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton shortened , abnormal
mandibular arch skeleton decreased size , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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