ENSDARG00000032013


Danio rerio

Features
Gene ID: ENSDARG00000032013
  
Biological name :pafah1b1a
  
Synonyms : pafah1b1a / platelet-activating factor acetylhydrolase 1b, regulatory subunit 1a / Q7T394
  
Possible biological names infered from orthology : P43034 / P63005 / PAFAH1B1 / platelet activating factor acetylhydrolase 1b regulatory subunit 1 / platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
  
Species: Danio rerio
  
Chr. number: 15
Strand: -1
Band:
Gene start: 25273185
Gene end: 25319663
  
Corresponding Affymetrix probe sets: Dr.15832.1.S1_at (Zebrafish Array)   Dr.16144.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000042217
Ensembl peptide - ENSDARP00000156578
NCBI entrez gene - 394246     See in Manteia.
swissprot - B2GQS8
swissprot - Q7T394
ZFIN ID - ZDB-GENE-040116-2
Ensembl - ENSDARG00000032013
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q9PTR5ENSGALG00000005834Gallus gallus
 P43034ENSG00000007168Homo sapiens
 P63005ENSMUSG00000020745Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pafah1b1b / platelet-activating factor acetylhydrolase 1b, regulatory subunit 1b / P43034* / PAFAH1B1* / platelet activating factor acetylhydrolase 1b regulatory subunit 1*ENSDARG0000002659594
wdr5 / WD repeat domain 5 / WDR5B* / Q9D7H2* / P61964* / P61965* / Q86VZ2* / WD repeat domain 5B*ENSDARG0000001690326
nle1 / notchless homolog 1 (Drosophila) / Q8VEJ4* / Q9NVX2* / notchless homolog 1* / Notchless protein homolog 1 *ENSDARG0000005710526
daw1 / dynein assembly factor with WDR repeat domains 1 / Q8N136* / dynein assembly factor with WD repeats 1*ENSDARG0000002146224
poc1b / A2CEH0 / POC1 centriolar protein B / Q8BHD1* / Q8TC44*ENSDARG0000002111021
snrnp40 / small nuclear ribonucleoprotein 40 (U5) / Q96DI7* / Q6PE01* / small nuclear ribonucleoprotein U5 subunit 40* / U5 small nuclear ribonucleoprotein 40 kDa protein *ENSDARG0000002316020
katnb1 / Q7ZUV2 / katanin p80 (WD repeat containing) subunit B 1 / Q9BVA0* / Q8BG40* / katanin regulatory subunit B1* / Katanin p80 WD40 repeat-containing subunit B1 *ENSDARG0000000545619
poc1a / POC1 centriolar protein A / Q8JZX3* / Q8NBT0*ENSDARG0000007853313
wdr38 / WD repeat domain 38 / Q5JTN6*ENSDARG0000004480112
wdr61 / WD repeat domain 61 / Q9ERF3* / Q9GZS3*ENSDARG0000000775511


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR006594  LIS1 homology motif
 IPR017252  Dynein regulator LIS1
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000132 establishment of mitotic spindle orientation IEA
 biological_processGO:0007017 microtubule-based process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007097 nuclear migration IBA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007281 germ cell development IBA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008090 retrograde axonal transport IBA
 biological_processGO:0022008 neurogenesis IBA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031023 microtubule organizing center organization IBA
 biological_processGO:0047496 vesicle transport along microtubule IBA
 biological_processGO:0048854 brain morphogenesis IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:2000574 regulation of microtubule motor activity IBA
 cellular_componentGO:0000776 kinetochore IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IBA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005875 microtubule associated complex IEA
 cellular_componentGO:0005938 cell cortex IBA
 cellular_componentGO:1904115 axon cytoplasm IEA
 molecular_functionGO:0008017 microtubule binding IBA
 molecular_functionGO:0070840 dynein complex binding IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
COPI-independent Golgi-to-ER retrograde traffic
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain morphology , abnormal
brain decreased size , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0001094 whole organism whole organism curved ventral , abnormal
whole organism lethal (sensu genetics) , abnormal
Show

 ZFA:0009090 pigment cell pigment cell morphology , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000032013 Q7T394 / pafah1b1a / platelet-activating factor acetylhydrolase 1b, regulatory subunit 1a / P43034* / P63005* / PAFAH1B1* / platelet-activating factor acetylhydrolase, isoform 1b, subunit 1...  / complex
 ENSDARG00000058047 pafah1b3 / platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit / Q15102* / Q61205* / Platelet-activating factor acetylhydrolase IB subunit gamma * / platelet activating fa...  / complex
 ENSDARG00000035352 pafah1b2 / platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 / P68402* / Q61206* / Platelet-activating factor acetylhydrolase IB subunit beta *  / complex






 

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