ENSDARG00000061268


Danio rerio

Features
Gene ID: ENSDARG00000061268
  
Biological name :ago2
  
Synonyms : ago2 / argonaute RISC catalytic component 2
  
Possible biological names infered from orthology : argonaute 2, RISC catalytic component / Protein argonaute-2 / Q8CJG0 / Q9UKV8
  
Species: Danio rerio
  
Chr. number: 19
Strand: 1
Band:
Gene start: 41479990
Gene end: 41499645
  
Corresponding Affymetrix probe sets: Dr.18175.2.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000081621
NCBI entrez gene - 570630     See in Manteia.
RefSeq - NM_001302222
RefSeq Peptide - NP_001289151
swissprot - E7EXY4
ZFIN ID - ZDB-GENE-110606-6
Ensembl - ENSDARG00000061268
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AGO2ENSGALG00000040957Gallus gallus
 AGO2ENSG00000123908Homo sapiens
 Ago2ENSMUSG00000036698Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ago1 / argonaute RISC catalytic component 1 / Q8CJG1* / Q9UL18* / Protein argonaute-1 * / argonaute 1, RISC catalytic component*ENSDARG0000009264479
ago3a / argonaute RISC catalytic component 3a / AGO3* / Q9H9G7* / argonaute 3, RISC catalytic component*ENSDARG0000005988878
ago3b / A3KPK0 / argonaute RISC catalytic component 3b / AGO3* / Q8CJF9* / Q9H9G7* / Protein argonaute-3 * / argonaute 3, RISC catalytic component*ENSDARG0000006307978
ago4 / argonaute RISC catalytic component 4 / Q9HCK5* / argonaute 4, RISC catalytic component*ENSDARG0000010085478
piwil1 / Q8UVX0 / piwi-like RNA-mediated gene silencing 1 / Q96J94* / Q9JMB7* / Piwi-like protein 1 *ENSDARG0000004169923
piwil2 / A2CEI6 / piwi-like RNA-mediated gene silencing 2 / Q8TC59* / Q8CDG1* / Piwi-like protein 2 *ENSDARG0000006260119


Protein motifs (from Interpro)
Interpro ID Name
 IPR003100  PAZ domain
 IPR003165  Piwi domain
 IPR012337  Ribonuclease H-like superfamily
 IPR014811  Argonaute, linker 1 domain
 IPR028602  Protein argonaute-2
 IPR032472  Argonaute linker 2 domain
 IPR032473  Protein argonaute, Mid domain
 IPR032474  Protein argonaute, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0031054 pre-miRNA processing IMP
 biological_processGO:0035196 production of miRNAs involved in gene silencing by miRNA IMP
 biological_processGO:0035278 miRNA mediated inhibition of translation IEA
 biological_processGO:0035279 mRNA cleavage involved in gene silencing by miRNA IEA
 biological_processGO:0043363 nucleate erythrocyte differentiation IMP
 biological_processGO:0045947 negative regulation of translational initiation IEA
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005845 mRNA cap binding complex IEA
 cellular_componentGO:0016442 RISC complex IEA
 cellular_componentGO:0035068 micro-ribonucleoprotein complex IEA
 molecular_functionGO:0000340 RNA 7-methylguanosine cap binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016891 endoribonuclease activity, producing 5"-phosphomonoesters IEA
 molecular_functionGO:0035197 siRNA binding IEA
 molecular_functionGO:0035198 miRNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070551 endoribonuclease activity, cleaving siRNA-paired mRNA IEA
 molecular_functionGO:0070883 pre-miRNA binding IDA


Pathways (from Reactome)
Pathway description
MicroRNA (miRNA) biogenesis
Small interfering RNA (siRNA) biogenesis
Post-transcriptional silencing by small RNAs
Transcriptional regulation by small RNAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000033 intermediate cell mass of mesoderm intermediate cell mass of mesoderm hemoglobin complex absent , abnormal
Show

 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte nucleus proportionality to nucleate erythrocyte cytoplasm, abnormal
nucleate erythrocyte hemoglobin complex decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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