ENSDARG00000062601


Danio rerio

Features
Gene ID: ENSDARG00000062601
  
Biological name :piwil2
  
Synonyms : A2CEI6 / piwil2 / piwi-like RNA-mediated gene silencing 2
  
Possible biological names infered from orthology : Piwi-like protein 2 / Q8CDG1 / Q8TC59
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 16428411
Gene end: 16475682
  
Corresponding Affymetrix probe sets: Dr.25574.1.A1_at (Zebrafish Array)   NM_001080199_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000085128
Ensembl peptide - ENSDARP00000139021
Ensembl peptide - ENSDARP00000114406
Ensembl peptide - ENSDARP00000114311
NCBI entrez gene - 572134     See in Manteia.
RefSeq - NM_001080199
RefSeq Peptide - NP_001073668
swissprot - A2CEI6
swissprot - A0A0R4IVB4
swissprot - A2CEI7
swissprot - T1ECU4
ZFIN ID - ZDB-GENE-060526-345
Ensembl - ENSDARG00000062601
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PIWIL2ENSG00000197181Homo sapiens
 Piwil2ENSMUSG00000033644Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
piwil1 / Q8UVX0 / piwi-like RNA-mediated gene silencing 1 / Q96J94* / Q9JMB7* / Piwi-like protein 1 *ENSDARG0000004169928
ago3a / argonaute RISC catalytic component 3a / AGO3* / Q9H9G7* / argonaute 3, RISC catalytic component*ENSDARG0000005988816
ago3b / A3KPK0 / argonaute RISC catalytic component 3b / AGO3* / Q8CJF9* / Q9H9G7* / Protein argonaute-3 * / argonaute 3, RISC catalytic component*ENSDARG0000006307916
ago1 / argonaute RISC catalytic component 1 / Q8CJG1* / Q9UL18* / Protein argonaute-1 * / argonaute 1, RISC catalytic component*ENSDARG0000009264416
ago4 / argonaute RISC catalytic component 4 / Q9HCK5* / argonaute 4, RISC catalytic component*ENSDARG0000010085416
ago2 / argonaute RISC catalytic component 2 / Q8CJG0* / Q9UKV8* / Protein argonaute-2 * / argonaute 2, RISC catalytic component*ENSDARG0000006126815


Protein motifs (from Interpro)
Interpro ID Name
 IPR003100  PAZ domain
 IPR003165  Piwi domain
 IPR012337  Ribonuclease H-like superfamily
 IPR014811  Argonaute, linker 1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000966 RNA 5"-end processing ISS
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007276 gamete generation IMP
 biological_processGO:0007283 spermatogenesis ISS
 biological_processGO:0010529 negative regulation of transposition ISS
 biological_processGO:0010628 positive regulation of gene expression IGI
 biological_processGO:0010991 negative regulation of SMAD protein complex assembly IPI
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030718 germ-line stem cell population maintenance IMP
 biological_processGO:0031047 gene silencing by RNA ISS
 biological_processGO:0034587 piRNA metabolic process IDA
 biological_processGO:0043046 DNA methylation involved in gamete generation ISS
 biological_processGO:0048477 oogenesis IEA
 biological_processGO:0051321 meiotic cell cycle IMP
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 biological_processGO:1990511 piRNA biosynthetic process ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0043186 P granule ISS
 cellular_componentGO:0071546 pi-body ISS
 cellular_componentGO:1990923 PET complex ISS
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004521 endoribonuclease activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0034584 piRNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001069 ventral fin fold ventral fin fold aplastic , abnormal
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 ZFA:0001094 whole organism whole organism wholly dorsalized , abnormal
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 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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