ENSDARG00000099045


Danio rerio

Features
Gene ID: ENSDARG00000099045
  
Biological name :cacnb2a
  
Synonyms : cacnb2a / calcium channel, voltage-dependent, beta 2a
  
Possible biological names infered from orthology : CACNB2 / calcium voltage-gated channel auxiliary subunit beta 2 / Q08289 / Q8CC27 / Voltage-dependent L-type calcium channel subunit beta-2
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 71792290
Gene end: 71837265
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000131709
Ensembl peptide - ENSDARP00000141789
Ensembl peptide - ENSDARP00000139872
Ensembl peptide - ENSDARP00000138740
Ensembl peptide - ENSDARP00000135723
Ensembl peptide - ENSDARP00000135383
Ensembl peptide - ENSDARP00000135297
Ensembl peptide - ENSDARP00000133097
NCBI entrez gene - 795492     See in Manteia.
RefSeq - NM_001083568
RefSeq Peptide - NP_001077037
swissprot - A0A0R4IWG7
swissprot - A0A0R4IQY8
swissprot - A0A0R4IMP5
swissprot - A0A0R4IM34
swissprot - A0A0R4IK22
swissprot - A0A0R4IFE8
swissprot - B2XY79
swissprot - A0A0R4IXU9
ZFIN ID - ZDB-GENE-080808-7
Ensembl - ENSDARG00000099045
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CACNB2ENSGALG00000008591Gallus gallus
 CACNB2ENSG00000165995Homo sapiens
 Cacnb2ENSMUSG00000057914Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cacnb1 / calcium channel, voltage-dependent, beta 1 subunit / Q02641* / Q8R3Z5* / calcium voltage-gated channel auxiliary subunit beta 1* / Voltage-dependent L-type calcium channel subunit beta-1 *ENSDARG0000000216750
cacnb4a / calcium channel, voltage-dependent, beta 4a subunit / O00305* / CACNB4* / Q8R0S4* / AC068547.1* / calcium voltage-gated channel auxiliary subunit beta 4* / Mus musculus calcium ch...ENSDARG0000000973846
cacnb4b / calcium channel, voltage-dependent, beta 4b subunit / O00305* / CACNB4* / Q8R0S4* / AC068547.1* / calcium voltage-gated channel auxiliary subunit beta 4* / Mus musculus calcium ch...ENSDARG0000006217446
cacnb3a / calcium channel, voltage-dependent, beta 3a / P54285* / P54284* / CACNB3* / calcium voltage-gated channel auxiliary subunit beta 3* / Mus musculus calcium channel, voltage-depende...ENSDARG0000000188143
cacnb3b / calcium channel, voltage-dependent, beta 3b / P54285* / P54284* / CACNB3* / calcium voltage-gated channel auxiliary subunit beta 3* / Mus musculus calcium channel, voltage-depende...ENSDARG0000007603043
cacnb2b / calcium channel, voltage-dependent, beta 2b / CACNB2* / Q08289* / Q8CC27* / calcium voltage-gated channel auxiliary subunit beta 2* / Voltage-dependent L-type calcium channel subu...ENSDARG0000005556538


Protein motifs (from Interpro)
Interpro ID Name
 IPR000584  Voltage-dependent calcium channel, L-type, beta subunit
 IPR001452  SH3 domain
 IPR005444  Voltage-dependent calcium channel, L-type, beta-2 subunit
 IPR008145  Guanylate kinase/L-type calcium channel beta subunit
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035605  CACNB2, SH3 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003143 embryonic heart tube morphogenesis IMP
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0005891 voltage-gated calcium channel complex IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IEA


Pathways (from Reactome)
Pathway description
Presynaptic depolarization and calcium channel opening
Regulation of insulin secretion
Phase 0 - rapid depolarisation
Phase 2 - plateau phase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle sarcomere organization decreased process quality , abnormal
cardiac ventricle cardiac muscle cell circular , abnormal
cardiac ventricle cardiac muscle cell decreased area , abnormal
cardiac ventricle decreased volume , abnormal
cardiac ventricle has fewer parts of type cardiac muscle cell , abnormal
Show

 ZFA:0000114 heart heart malformed , abnormal
heart edematous , abnormal
heart decreased contractility , abnormal
Show

 ZFA:0000360 heart tube heart tube increased fragility , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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