ENSDARG00000100252


Danio rerio

Features
Gene ID: ENSDARG00000100252
  
Biological name :capzb
  
Synonyms : capping protein (actin filament) muscle Z-line, beta / capzb
  
Possible biological names infered from orthology : capping actin protein of muscle Z-line beta subunit / F-actin-capping protein subunit beta / P47756 / P47757
  
Species: Danio rerio
  
Chr. number: 22
Strand: 1
Band:
Gene start: 396840
Gene end: 410544
  
Corresponding Affymetrix probe sets: Dr.20079.1.A1_at (Zebrafish Array)   Dr.25474.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000140899
NCBI entrez gene - 335083     See in Manteia.
swissprot - Q7SXP1
ZFIN ID - ZDB-GENE-030131-7023
Ensembl - ENSDARG00000100252
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CAPZBENSGALG00000004034Gallus gallus
 CAPZBENSG00000077549Homo sapiens
 CapzbENSMUSG00000028745Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001698  F-actin-capping protein subunit beta
 IPR019771  F-actin capping protein, beta subunit, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IBA
 biological_processGO:0010591 regulation of lamellipodium assembly IBA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0051016 barbed-end actin filament capping IBA
 biological_processGO:0051490 negative regulation of filopodium assembly IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005884 actin filament IBA
 cellular_componentGO:0008290 F-actin capping protein complex IBA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0051015 actin filament binding IBA


Pathways (from Reactome)
Pathway description
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000108 fin fin rough , abnormal
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 ZFA:0000292 surface structure surface structure quality , abnormal
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 ZFA:0000368 integument integument rough , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001161 pectoral fin pectoral fin stubby , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage hypoplastic , abnormal
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 ZFA:0001273 ventral mandibular arch ventral mandibular arch decreased length , abnormal
ventral mandibular arch decreased size , abnormal
ventral mandibular arch hypoplastic , abnormal
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 ZFA:0001405 ethmoid cartilage ethmoid cartilage morphology , abnormal
ethmoid cartilage cleft , abnormal
ethmoid cartilage circular , abnormal
ethmoid cartilage decreased length , abnormal
ethmoid cartilage decreased width , abnormal
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 ZFA:0001652 head muscle head muscle malformed , abnormal
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 ZFA:0005277 skeletal muscle skeletal muscle disorganized , abnormal
skeletal muscle sarcomere disorganized , abnormal
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 ZFA:0009091 melanocyte melanocyte position , abnormal
Show

 ZFA:0009115 skeletal muscle cell skeletal muscle cell decreased amount , abnormal
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 ZFA:0009183 epidermal cell epidermal cell filamentous actin increased distribution , abnormal
epidermal cell circular , abnormal
epidermal cell decreased size , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000056090 capza1b / capping protein (actin filament) muscle Z-line, alpha 1b / P52907* / CAPZA1* / 4933400A11Rik* / RIKEN cDNA 4933400A11 gene* / capping actin protein of muscle Z-line alpha subunit 1*  / complex / reaction
 ENSDARG00000035924 dync1li2 / dynein, cytoplasmic 1, light intermediate chain 2 / O43237* / Q6PDL0* / Cytoplasmic dynein 1 light intermediate chain 2 *  / complex
 ENSDARG00000058454 dynll1 / dynein, light chain, LC8-type 1 / P63168* / P63167* / BC048507* / cDNA sequence BC048507* / Dynein light chain 1, cytoplasmic *  / complex
 ENSDARG00000041363 dctn3 / dynactin 3 (p22) / O75935* / Q9Z0Y1* / dynactin subunit 3*  / complex
 ENSDARG00000060948 dync1i1 / dynein, cytoplasmic 1, intermediate chain 1 / O14576* / O88485* / Cytoplasmic dynein 1 intermediate chain 1 *  / complex
 ENSDARG00000056753 dctn1b / dynactin 1b / DCTN1* / O08788* / Q14203* / dynactin subunit 1* / Mus musculus dynactin 1 (Dctn1), transcript variant 4, mRNA.*  / complex
 ENSDARG00000069790 dynll2a / dynein, light chain, LC8-type 2a / Q9D0M5* / DYNLL2* / Q96FJ2* / dynein light chain LC8-type 2* / Dynein light chain 2, cytoplasmic *  / complex
 ENSDARG00000019743 dctn1a / dynactin 1a / DCTN1* / Q14203* / dynactin subunit 1*  / complex
 ENSDARG00000098317 dync1li1 / dynein, cytoplasmic 1, light intermediate chain 1 / Q8R1Q8* / Q9Y6G9* / Cytoplasmic dynein 1 light intermediate chain 1 *  / complex






 

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