ENSDARG00000019743


Danio rerio

Features
Gene ID: ENSDARG00000019743
  
Biological name :dctn1a
  
Synonyms : dctn1a / dynactin 1a
  
Possible biological names infered from orthology : DCTN1 / dynactin subunit 1 / Mus musculus dynactin 1 (Dctn1), transcript variant 4, mRNA. / O08788 / Q14203
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 1062972
Gene end: 1108935
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000147161
Ensembl peptide - ENSDARP00000149662
Ensembl peptide - ENSDARP00000093570
Ensembl peptide - ENSDARP00000144030
NCBI entrez gene - 407638     See in Manteia.
RefSeq - NM_001077212
RefSeq Peptide - NP_001070680
swissprot - A0A286YA27
swissprot - F1R0W9
ZFIN ID - ZDB-GENE-070117-2205
Ensembl - ENSDARG00000019743
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DCTN1ENSG00000204843Homo sapiens
 Dctn1ENSMUSG00000031865Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
dctn1b / dynactin 1b / DCTN1* / O08788* / Q14203* / dynactin subunit 1* / Mus musculus dynactin 1 (Dctn1), transcript variant 4, mRNA.*ENSDARG0000005675374
clip1a / CAP-GLY domain containing linker protein 1aENSDARG0000007872216
cep350 / centrosomal protein 350ENSDARG0000005800012
clip2 / CAP-GLY domain containing linker protein 2 / Q9UDT6* / Q9Z0H8*ENSDARG0000005959612
CLIP4 / si:dkeyp-47f9.4 / Q8CI96* / Q8N3C7* / CAP-Gly domain-containing linker protein 4 * / CAP-Gly domain containing linker protein family member 4*ENSDARG000000969615
clip3 / CAP-GLY domain containing linker protein 3 / B9EHT4* / Q96DZ5* / AC006030.1*ENSDARG000000544564
CABZ01072096.1ENSDARG000000794833
tbcb / tubulin folding cofactor B / CLIP1* / P30622* / Q922J3* / CAP-Gly domain containing linker protein 1*ENSDARG000000684041
zgc:103755 / E9Q309* / CEP350* / Q5VT06* / centrosomal protein 350* / Centrosome-associated protein 350 *ENSDARG000001046630


Protein motifs (from Interpro)
Interpro ID Name
 IPR000938  CAP Gly-rich domain
 IPR022157  Dynein associated protein
 IPR027663  Dynactin subunit 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007097 nuclear migration IMP
 biological_processGO:0010842 retina layer formation IMP
 biological_processGO:0010970 transport along microtubule IEA
 biological_processGO:0045176 apical protein localization IMP
 biological_processGO:0048663 neuron fate commitment IMP
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0060042 retina morphogenesis in camera-type eye IMP
 biological_processGO:0060219 camera-type eye photoreceptor cell differentiation IGI
 cellular_componentGO:0005869 dynactin complex IEA
 molecular_functionGO:0070840 dynein complex binding IEA


Pathways (from Reactome)
Pathway description
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000024 retinal ganglion cell layer retinal ganglion cell layer retinal ganglion cell increased amount , abnormal
Show

 ZFA:0000035 lens lens protruding , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
eye decreased diameter , abnormal
eye quality , abnormal
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 ZFA:0000143 retinal photoreceptor layer retinal photoreceptor layer photoreceptor cell absent , abnormal
retinal photoreceptor layer morphology , abnormal
retinal photoreceptor layer mislocalised , abnormal
retinal photoreceptor layer aplastic , abnormal
retinal photoreceptor layer absent , abnormal
retinal photoreceptor layer poorly differentiated , abnormal
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 ZFA:0000152 retina retina nucleus mislocalised , abnormal
retina lacks parts or has fewer parts of type eye photoreceptor cell photoreceptor outer segment, abnormal
retina central region lacks all parts of type photoreceptor cell , abnormal
retina peripheral region morphology , abnormal
retina cell death increased occurrence , abnormal
retina quality , abnormal
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 ZFA:0000175 posterior lateral line nerve posterior lateral line nerve decreased length , abnormal
posterior lateral line nerve truncated , abnormal
posterior lateral line nerve decreased diameter , abnormal
posterior lateral line nerve retrograde axonal transport decreased occurrence , abnormal
posterior lateral line nerve axon terminus increased amount , abnormal
posterior lateral line nerve axon terminus swollen , abnormal
posterior lateral line nerve axon terminus has extra parts of type posterior lateral line nerve mitochondrion, abnormal
posterior lateral line nerve anterograde axonal transport of mitochondrion decreased occurrence , abnormal
posterior lateral line nerve retrograde axonal transport of mitochondrion decreased occurrence , abnormal
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 ZFA:0000282 sensory system sensory system quality , abnormal
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 ZFA:0000396 nervous system nervous system quality , abnormal
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 ZFA:0000940 posterior lateral line neuromast posterior lateral line neuromast axon terminus increased amount , abnormal
posterior lateral line neuromast axon terminus swollen , abnormal
posterior lateral line neuromast axon terminus has extra parts of type posterior lateral line neuromast mitochondrion, abnormal
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 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
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 ZFA:0009127 photoreceptor cell photoreceptor cell morphology , abnormal
photoreceptor cell circular , abnormal
photoreceptor cell decreased amount , abnormal
photoreceptor cell photoreceptor outer segment morphology , abnormal
photoreceptor cell photoreceptor outer segment disorganized , abnormal
photoreceptor cell photoreceptor inner segment absent , abnormal
photoreceptor cell absent , abnormal
photoreceptor cell photoreceptor outer segment decreased size , abnormal
photoreceptor cell photoreceptor outer segment decreased amount , abnormal
photoreceptor cell nucleus disorganized , abnormal
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 ZFA:0009154 eye photoreceptor cell eye photoreceptor cell synapse poorly differentiated , abnormal
eye photoreceptor cell photoreceptor outer segment decreased length , abnormal
eye photoreceptor cell photoreceptor inner segment malformed , abnormal
eye photoreceptor cell Golgi apparatus mislocalised , abnormal
eye photoreceptor cell decreased amount , abnormal
eye photoreceptor cell shape , abnormal
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 ZFA:0009275 retinal rod cell retinal rod cell photoreceptor outer segment physical object quality , abnormal
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 ZFA:0009280 Muller cell Muller cell decreased amount , abnormal
Muller cell cell projection disorganized , abnormal
Muller cell cell projection decreased amount , abnormal
Muller cell increased amount , abnormal
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 ZFA:0009310 retinal ganglion cell retinal ganglion cell increased amount , abnormal
retinal ganglion cell mislocalised , abnormal
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 ZFA:0009315 horizontal cell horizontal cell decreased amount , abnormal
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 ZFA:0009318 retinal bipolar neuron retinal bipolar neuron decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000035924 dync1li2 / dynein, cytoplasmic 1, light intermediate chain 2 / O43237* / Q6PDL0* / Cytoplasmic dynein 1 light intermediate chain 2 *  / complex
 ENSDARG00000058454 dynll1 / dynein, light chain, LC8-type 1 / P63168* / P63167* / BC048507* / cDNA sequence BC048507* / Dynein light chain 1, cytoplasmic *  / complex
 ENSDARG00000060948 dync1i1 / dynein, cytoplasmic 1, intermediate chain 1 / O14576* / O88485* / Cytoplasmic dynein 1 intermediate chain 1 *  / complex
 ENSDARG00000069790 dynll2a / dynein, light chain, LC8-type 2a / Q9D0M5* / DYNLL2* / Q96FJ2* / dynein light chain LC8-type 2* / Dynein light chain 2, cytoplasmic *  / complex
 ENSDARG00000056090 capza1b / capping protein (actin filament) muscle Z-line, alpha 1b / P52907* / CAPZA1* / 4933400A11Rik* / RIKEN cDNA 4933400A11 gene* / capping actin protein of muscle Z-line alpha subunit 1*  / complex
 ENSDARG00000041363 dctn3 / dynactin 3 (p22) / O75935* / Q9Z0Y1* / dynactin subunit 3*  / complex
 ENSDARG00000056753 dctn1b / dynactin 1b / DCTN1* / O08788* / Q14203* / dynactin subunit 1* / Mus musculus dynactin 1 (Dctn1), transcript variant 4, mRNA.*  / complex
 ENSDARG00000019743 dctn1a / dynactin 1a / DCTN1* / Q14203* / dynactin subunit 1*  / complex
 ENSDARG00000100252 capzb / capping protein (actin filament) muscle Z-line, beta / P47756* / capping actin protein of muscle Z-line beta subunit*  / complex
 ENSDARG00000098317 dync1li1 / dynein, cytoplasmic 1, light intermediate chain 1 / Q8R1Q8* / Q9Y6G9* / Cytoplasmic dynein 1 light intermediate chain 1 *  / complex






 

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