ENSG00000016602


Homo sapiens

Features
Gene ID: ENSG00000016602
  
Biological name :CLCA4
  
Synonyms : chloride channel accessory 4 / CLCA4 / Q14CN2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p22.3
Gene start: 86547078
Gene end: 86580754
  
Corresponding Affymetrix probe sets: 220026_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000359594
NCBI entrez gene - 22802     See in Manteia.
OMIM - 616857
RefSeq - NM_012128
RefSeq - XM_011541015
RefSeq Peptide - NP_036260
swissprot - Q14CN2
Ensembl - ENSG00000016602
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 clca1ENSDARG00000016290Danio rerio
 clca1ENSDARG00000100941Danio rerio
 clca5.1ENSDARG00000099606Danio rerio
 si:ch211-116o3.3ENSDARG00000086498Danio rerio
 ENSGALG00000006322Gallus gallus
 Clca4aENSMUSG00000068547Mus musculus
 Clca4bENSMUSG00000074195Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CLCA1 / A8K7I4 / chloride channel accessory 1ENSG0000001649061
CLCA2 / Q9UQC9 / chloride channel accessory 2ENSG0000013797543


Protein motifs (from Interpro)
Interpro ID Name
 IPR002035  von Willebrand factor, type A
 IPR004727  Calcium-activated chloride channel protein, chordata
 IPR013642  Calcium-activated chloride channel, N-terminal
 IPR013783  Immunoglobulin-like fold
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0034220 ion transmembrane transport TAS
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004222 metalloendopeptidase activity TAS
 molecular_functionGO:0005229 intracellular calcium activated chloride channel activity IBA
 molecular_functionGO:0005254 chloride channel activity TAS
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0001738 Exocrine pancreatic insufficiency 
Show

 HP:0002024 Malabsorption 
Show

 HP:0002205 Recurrent respiratory infections 
Show

 HP:0002206 Pulmonary fibrosis 
Show

 HP:0002240 Hepatomegaly "An abnormal enlargment of the liver." [HPO:curators]
Show

 HP:0002613 Biliary cirrhosis 
Show

 HP:0002721 Immunodeficiency 
Show

 HP:0004313 Reduced immunoglobulin levels 
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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