ENSG00000119121
Homo sapiens transport TRPM6 ion activity protein membrane domain cation channel transmembrane binding kinase calcium superfamily trpm tetramerisation phosphorylation metal plasma mhck ef kinase-like transient receptor potential subfamily m member response toxic substance
Features See expression report in BioGPS See gene description in Wikigenes See gene description in GeneCards See co-cited genes in PubMed Ortholog prediction (from Ensembl )Paralog prediction (from Ensembl ) TRPM7 / Q96QT4 / transient receptor potential cation channel subfamily M member 7 ENSG00000092439 51 TRPM3 / Q9HCF6 / transient receptor potential cation channel subfamily M member 3 ENSG00000083067 36 TRPM1 / Q7Z4N2 / transient receptor potential cation channel subfamily M member 1 ENSG00000134160 35 TRPM2 / O94759 / transient receptor potential cation channel subfamily M member 2 ENSG00000142185 20 TRPM5 / Q9NZQ8 / transient receptor potential cation channel subfamily M member 5 ENSG00000070985 16 TRPM4 / Q8TD43 / transient receptor potential cation channel subfamily M member 4 ENSG00000130529 16 TRPM8 / Q7Z2W7 / transient receptor potential cation channel subfamily M member 8 ENSG00000144481 14
Protein motifs (from Interpro ) IPR004166 MHCK/EF2 kinase IPR005821 Ion transport domain IPR011009 Protein kinase-like domain superfamily IPR029597 Transient receptor potential cation channel subfamily M member 6 IPR032415 TRPM, tetramerisation domain IPR037162 TRPM, tetramerisation domain superfamily
Gene Ontology (GO ) nitrogen compound metabolic process cellular metabolic process primary metabolic process organic substance metabolic process establishment of localization response to chemical cellular component organization cellular component biogenesis nitrogen compound metabolic process cellular metabolic process primary metabolic process organic substance metabolic process establishment of localization response to chemical cellular component organization cellular component biogenesis nitrogen compound metabolic process cellular metabolic process primary metabolic process organic substance metabolic process establishment of localization response to chemical cellular component organization cellular component biogenesis nitrogen compound metabolic process cellular metabolic process primary metabolic process organic substance metabolic process establishment of localization response to chemical cellular component organization cellular component biogenesis nitrogen compound metabolic process cellular metabolic process primary metabolic process organic substance metabolic process establishment of localization response to chemical cellular component organization cellular component biogenesis nitrogen compound metabolic process cellular metabolic process primary metabolic process organic substance metabolic process establishment of localization response to chemical cellular component organization cellular component biogenesis nitrogen compound metabolic process cellular metabolic process primary metabolic process organic substance metabolic process establishment of localization response to chemical cellular component organization cellular component biogenesis nitrogen compound metabolic process cellular metabolic process primary metabolic process organic substance metabolic process establishment of localization response to chemical cellular component organization cellular component biogenesis nitrogen compound metabolic process cellular metabolic process primary metabolic process organic substance metabolic process establishment of localization response to chemical cellular component organization cellular component biogenesis nitrogen compound metabolic process cellular metabolic process primary metabolic process organic substance metabolic process establishment of localization response to chemical cellular component organization cellular component biogenesis nitrogen compoundnitrogen compound metabolic process cellular metabolicellular metabolic process primary metabolicprimary metabolic process organic substanceorganic substance metabolic process establishment of establishment of localization response to chemiresponse to chemical cellular componencellular component organization cellular componencellular component biogenesis organic cyclic compound binding heterocyclic compound binding small molecule binding catalytic activity, acting on a protein transferase activity transmembrane transporter activity protein binding ion binding carbohydrate derivative binding drug binding organic cyclic compound binding heterocyclic compound binding small molecule binding catalytic activity, acting on a protein transferase activity transmembrane transporter activity protein binding ion binding carbohydrate derivative binding drug binding organic cyclic compound binding heterocyclic compound binding small molecule binding catalytic activity, acting on a protein transferase activity transmembrane transporter activity protein binding ion binding carbohydrate derivative binding drug binding organic cyclic compound binding heterocyclic compound binding small molecule binding catalytic activity, acting on a protein transferase activity transmembrane transporter activity protein binding ion binding carbohydrate derivative binding drug binding organic cyclic compound binding heterocyclic compound binding small molecule binding catalytic activity, acting on a protein transferase activity transmembrane transporter activity protein binding ion binding carbohydrate derivative binding drug binding organic cyclic compound binding heterocyclic compound binding small molecule binding catalytic activity, acting on a protein transferase activity transmembrane transporter activity protein binding ion binding carbohydrate derivative binding drug binding organic cyclic compound binding heterocyclic compound binding small molecule binding catalytic activity, acting on a protein transferase activity transmembrane transporter activity protein binding ion binding carbohydrate derivative binding drug binding organic cyclic compound binding heterocyclic compound binding small molecule binding catalytic activity, acting on a protein transferase activity transmembrane transporter activity protein binding ion binding carbohydrate derivative binding drug binding organic cyclic compound binding heterocyclic compound binding small molecule binding catalytic activity, acting on a protein transferase activity transmembrane transporter activity protein binding ion binding carbohydrate derivative binding drug binding organic cyclic compound binding heterocyclic compound binding small molecule binding catalytic activity, acting on a protein transferase activity transmembrane transporter activity protein binding ion binding carbohydrate derivative binding drug binding organic cyclicorganic cyclic compound binding heterocyclic cheterocyclic compound binding small moleculesmall molecule binding catalytic acticatalytic activity, acting on a protein transferase actransferase activity transmembrane transmembrane transporter activity protein bindinprotein binding ion bindingion binding carbohydrate dcarbohydrate derivative binding drug bindingdrug binding cell membrane cell membrane cell membrane cell membrane cell membrane cell membrane cell membrane cell membrane cell membrane cell membrane cellcell membranemembrane
Pathways (from Reactome )Phenotype (from MGI , Zfin or HPO ) Autosomal recessive inheritance Neurological abnormality Abnormality of musculature Metabolism abnormality Age of onset Autosomal recessive inheritance Neurological abnormality Abnormality of musculature Metabolism abnormality Age of onset Autosomal recessive inheritance Neurological abnormality Abnormality of musculature Metabolism abnormality Age of onset Autosomal recessive inheritance Neurological abnormality Abnormality of musculature Metabolism abnormality Age of onset Autosomal recessive inheritance Neurological abnormality Abnormality of musculature Metabolism abnormality Age of onset Autosomal recessive inheritance Neurological abnormality Abnormality of musculature Metabolism abnormality Age of onset Autosomal recessive inheritance Neurological abnormality Abnormality of musculature Metabolism abnormality Age of onset Autosomal recessive inheritance Neurological abnormality Abnormality of musculature Metabolism abnormality Age of onset Autosomal recessive inheritance Neurological abnormality Abnormality of musculature Metabolism abnormality Age of onset Autosomal recessive inheritance Neurological abnormality Abnormality of musculature Metabolism abnormality Age of onset Autosomal recessive inheritaAutosomal recessive inheritance Neurological abnormalityNeurological abnormality Abnormality of musculatureAbnormality of musculature Metabolism abnormalityMetabolism abnormality Age of onsetAge of onset HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
Show HP:0001250 Seizures "Seizures are an intermittent `abnormality of the central nervous system` (FMA:HP:0002011) due to a sudden, excessive, disorderly discharge of cerebral neurons and characterized clinically by some combination of disturbance of sensation, loss of consciousness, impairment of psychic function, or convulsive movements." [HPO:probinson]
Show HP:0001281 Tetany
Show HP:0002901 Hypocalcemia "A level of blood calcium that is lower than normal." [HPO:curators]
Show HP:0002917 Hypomagnesemia
Show HP:0003593 Early onset
Show
Interacting proteins (from Reactome )No match
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