ENSG00000134160


Homo sapiens

Features
Gene ID: ENSG00000134160
  
Biological name :TRPM1
  
Synonyms : Q7Z4N2 / transient receptor potential cation channel subfamily M member 1 / TRPM1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q13.3
Gene start: 31001061
Gene end: 31161273
  
Corresponding Affymetrix probe sets: 206479_at (Human Genome U133 Plus 2.0 Array)   237069_s_at (Human Genome U133 Plus 2.0 Array)   237070_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000453477
Ensembl peptide - ENSP00000454077
Ensembl peptide - ENSP00000453851
Ensembl peptide - ENSP00000453644
Ensembl peptide - ENSP00000256552
Ensembl peptide - ENSP00000380897
Ensembl peptide - ENSP00000437849
Ensembl peptide - ENSP00000452946
Ensembl peptide - ENSP00000453119
NCBI entrez gene - 4308     See in Manteia.
OMIM - 603576
RefSeq - NM_002420
RefSeq - NM_001252020
RefSeq - NM_001252024
RefSeq - NM_001252030
RefSeq Peptide - NP_001238949
RefSeq Peptide - NP_001238959
RefSeq Peptide - NP_002411
RefSeq Peptide - NP_001238953
swissprot - Q7Z4N2
swissprot - A0A0A0MTQ9
swissprot - H0YKU7
swissprot - H0YM61
swissprot - A0A0A0MTR0
Ensembl - ENSG00000134160
  
Related genetic diseases (OMIM): 613216 - Night blindness, congenital stationary (complete), 1C, autosomal recessive, 613216
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trpm1aENSDARG00000011259Danio rerio
 trpm1bENSDARG00000103476Danio rerio
 TRPM1ENSGALG00000003849Gallus gallus
 Trpm1ENSMUSG00000030523Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TRPM3 / Q9HCF6 / transient receptor potential cation channel subfamily M member 3ENSG0000008306761
TRPM7 / Q96QT4 / transient receptor potential cation channel subfamily M member 7ENSG0000009243945
TRPM6 / Q9BX84 / transient receptor potential cation channel subfamily M member 6ENSG0000011912143
TRPM2 / O94759 / transient receptor potential cation channel subfamily M member 2ENSG0000014218524
TRPM4 / Q8TD43 / transient receptor potential cation channel subfamily M member 4ENSG0000013052921
TRPM5 / Q9NZQ8 / transient receptor potential cation channel subfamily M member 5ENSG0000007098520
TRPM8 / Q7Z2W7 / transient receptor potential cation channel subfamily M member 8ENSG0000014448119


Protein motifs (from Interpro)
Interpro ID Name
 IPR005821  Ion transport domain
 IPR029588  Transient receptor potential cation channel subfamily M member 1
 IPR032415  TRPM, tetramerisation domain
 IPR037162  TRPM, tetramerisation domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007216 G-protein coupled glutamate receptor signaling pathway IMP
 biological_processGO:0007601 visual perception IMP
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0046548 retinal rod cell development IEA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0051262 protein tetramerization IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060402 calcium ion transport into cytosol IDA
 biological_processGO:0070588 calcium ion transmembrane transport TAS
 biological_processGO:0071482 cellular response to light stimulus IMP
 biological_processGO:0098655 cation transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0035841 new growing cell tip IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005261 cation channel activity IEA
 molecular_functionGO:0005262 calcium channel activity TAS


Pathways (from Reactome)
Pathway description
TRP channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000486 Strabismus "Strabismus (also known as squint) is a condition in which the eyes are not properly aligned with each other." [HPO:curators]
Show

 HP:0000512 Abnormal electroretinogram "Any abnormality of the electrical responses of various cell types in the retina as measured by electroretinography." [HPO:curators]
Show

 HP:0000545 Myopia 
Show

 HP:0000639 Nystagmus "Rhythmic, involuntary oscillations of one or both eyes related to abnormality in fixation, conjugate gaze, or vestibular mechanisms." [HPO:curators]
Show

 HP:0000662 Night blindness 
Show

 HP:0000958 Dry skin 
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 HP:0000964 Eczema "Eczema is a form of dermatitis. The term eczema is broadly applied to a range of persistent skin conditions and can be related to a number of underlying conditions. Manifestations of eczema can include dryness and recurring skin rashes with redness, skin edema, itching and dryness, crusting, flaking, blistering, cracking, oozing, or bleeding." [HPO:curators]
Show

 HP:0007642 Congenital stationary night blindness 
Show

 HP:0007663 Decreased central vision 
Show

 HP:0007766 Hypoplastic optic disks 
Show

 HP:0008002 Macular pigmentary changes 
Show

 HP:0011003 Severe Myopia 
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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