ENSG00000138069


Homo sapiens

Features
Gene ID: ENSG00000138069
  
Biological name :RAB1A
  
Synonyms : P62820 / RAB1A / RAB1A, member RAS oncogene family
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p14
Gene start: 65070701
Gene end: 65130106
  
Corresponding Affymetrix probe sets: 207791_s_at (Human Genome U133 Plus 2.0 Array)   208724_s_at (Human Genome U133 Plus 2.0 Array)   213440_at (Human Genome U133 Plus 2.0 Array)   239570_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000387286
Ensembl peptide - ENSP00000381540
Ensembl peptide - ENSP00000386451
Ensembl peptide - ENSP00000386672
NCBI entrez gene - 5861     See in Manteia.
OMIM - 179508
RefSeq - XM_005264468
RefSeq - NM_004161
RefSeq - NM_015543
RefSeq Peptide - NP_004152
RefSeq Peptide - NP_056358
swissprot - P62820
swissprot - Q5U0I6
swissprot - E7END7
Ensembl - ENSG00000138069
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab1abENSDARG00000029663Danio rerio
 RAB1BENSGALG00000031582Gallus gallus
 Rab1ENSMUSG00000020149Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAB1B / Q9H0U4 / RAB1B, member RAS oncogene familyENSG0000017490391
RAB35 / Q15286 / RAB35, member RAS oncogene familyENSG0000011173754
RAB19 / A4D1S5 / RAB19, member RAS oncogene familyENSG0000014695545
RAB43 / Q86YS6 / RAB43, member RAS oncogene familyENSG0000017278045
RAB26 / Q9ULW5 / RAB26, member RAS oncogene familyENSG0000016796443
RAB30 / Q15771 / RAB30, member RAS oncogene familyENSG0000013750242
Q14088 / RAB33A / RAB33A, member RAS oncogene familyENSG0000013459441
Q12829 / RAB40B / RAB40B, member RAS oncogene familyENSG0000014154239
Q9H082 / RAB33B / RAB33B, member RAS oncogene familyENSG0000017200739
Q96S21 / RAB40C / RAB40C, member RAS oncogene familyENSG0000019756239
P0C0E4 / RAB40AL / RAB40A likeENSG0000010212838
Q8WXH6 / RAB40A / RAB40A, member RAS oncogene familyENSG0000017247638
RAB37 / Q96AX2 / RAB37, member RAS oncogene familyENSG0000017279438


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000045 autophagosome assembly IMP
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS
 biological_processGO:0006897 endocytosis IMP
 biological_processGO:0006914 autophagy IMP
 biological_processGO:0007030 Golgi organization IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport TAS
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0019068 virion assembly IMP
 biological_processGO:0030252 growth hormone secretion IMP
 biological_processGO:0032402 melanosome transport IEA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IEA
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0047496 vesicle transport along microtubule IMP
 biological_processGO:0048208 COPII vesicle coating TAS
 biological_processGO:0072606 interleukin-8 secretion IMP
 biological_processGO:0090110 cargo loading into COPII-coated vesicle IMP
 biological_processGO:1903020 positive regulation of glycoprotein metabolic process IGI
 biological_processGO:1904668 positive regulation of ubiquitin protein ligase activity TAS
 cellular_componentGO:0000139 Golgi membrane IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IBA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030658 transport vesicle membrane TAS
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
Golgi Cisternae Pericentriolar Stack Reorganization
COPII-mediated vesicle transport
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138802 O95487 / SEC24B / SEC24 homolog B, COPII coat complex component  / complex / reaction
 ENSG00000138674 O94979 / SEC31A / SEC31 homolog A, COPII coat complex component  / complex / reaction
 ENSG00000138768 USO1 / O60763 / USO1 vesicle transport factor  / complex / reaction
 ENSG00000134057 CCNB1 / P14635 / cyclin B1  / reaction
 ENSG00000141551 CSNK1D / P48730 / casein kinase 1 delta  / reaction
 ENSG00000157456 CCNB2 / O95067 / cyclin B2  / reaction
 ENSG00000100934 Q15436 / SEC23A / Sec23 homolog A, coat complex II component  / complex / reaction
 ENSG00000150961 O94855 / SEC24D / SEC24 homolog D, COPII coat complex component  / complex / reaction
 ENSG00000157020 SEC13 / P55735 / SEC13 homolog, nuclear pore and COPII coat complex component  / complex / reaction
 ENSG00000176986 P53992 / SEC24C / SEC24 homolog C, COPII coat complex component  / complex / reaction
 ENSG00000170312 CDK1 / P06493 / cyclin dependent kinase 1  / reaction
 ENSG00000113615 O95486 / SEC24A / SEC24 homolog A, COPII coat complex component  / complex / reaction
 ENSG00000114745 Q9BQQ3 / GORASP1 / golgi reassembly stacking protein 1  / complex / reaction
 ENSG00000107651 Q9Y6Y8 / SEC23IP / SEC23 interacting protein  / complex / reaction
 ENSG00000166851 PLK1 / P53350 / polo like kinase 1  / complex / reaction
 ENSG00000188419 CHM / P24386 / CHM, Rab escort protein 1  / complex
 ENSG00000203668 CHML / P26374 / CHM like, Rab escort protein 2  / complex
 ENSG00000057608 GDI2 / P50395 / GDP dissociation inhibitor 2  / complex
 ENSG00000167110 GOLGA2 / Q08379 / golgin A2  / complex / reaction
 ENSG00000203879 GDI1 / P31150 / GDP dissociation inhibitor 1  / complex
 ENSG00000265808 O75396 / SEC22B / SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)  / complex / reaction






 

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