ENSMUSG00000020149


Mus musculus

Features
Gene ID: ENSMUSG00000020149
  
Biological name :Rab1
  
Synonyms : P62821 / Rab1 / Ras-related protein Rab-1A
  
Possible biological names infered from orthology : P62820 / RAB1A / RAB1A, member RAS oncogene family
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A3.1
Gene start: 20201432
Gene end: 20226856
  
Corresponding Affymetrix probe sets: 10374466 (MoGene1.0st)   1416082_at (Mouse Genome 430 2.0 Array)   1448210_at (Mouse Genome 430 2.0 Array)   1457537_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020358
Ensembl peptide - ENSMUSP00000105230
Ensembl peptide - ENSMUSP00000105231
Ensembl peptide - ENSMUSP00000127330
NCBI entrez gene - 19324     See in Manteia.
MGI - MGI:97842
RefSeq - NM_008996
RefSeq Peptide - NP_033022
swissprot - P62821
swissprot - Q0PD67
swissprot - Q5SW86
swissprot - Q5SW87
swissprot - Q5SW88
Ensembl - ENSMUSG00000020149
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rab1abENSDARG00000029663Danio rerio
 RAB1BENSGALG00000031582Gallus gallus
 RAB1AENSG00000138069Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rab1b / Q9D1G1 / RAB1B, member RAS oncogene family / Q9H0U4*ENSMUSG0000002487090
Rab35 / Q6PHN9 / RAB35, member RAS oncogene family / Q15286*ENSMUSG0000002951854
Rab19 / P35294 / Ras-related protein Rab-19 / A4D1S5* / RAB19, member RAS oncogene family*ENSMUSG0000002992344
Rab26 / Q504M8 / RAB26, member RAS oncogene family / Q9ULW5*ENSMUSG0000007965743
Rab43 / Q8CG50 / RAB43, member RAS oncogene family / Q86YS6*ENSMUSG0000003005542
Rab30 / Q923S9 / RAB30, member RAS oncogene family / Q15771*ENSMUSG0000003064342
P97950 / Rab33a / RAB33A, member RAS oncogene family / Q14088*ENSMUSG0000003110441
Rab37 / RAB37, member RAS oncogene family / Q96AX2*ENSMUSG0000002073240
Rab40b / Rab40B, member RAS oncogene family / Q12829* / RAB40A* / Q8WXH6* / P0C0E4* / RAB40AL* / RAB40A like* / RAB40A, member RAS oncogene family*ENSMUSG0000002517039
Q8VHQ4 / Rab40c / Rab40C, member RAS oncogene family / Q96S21*ENSMUSG0000002573039
O35963 / Rab33b / RAB33B, member RAS oncogene family / Q9H082*ENSMUSG0000002773938


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000045 autophagosome assembly IEA
 biological_processGO:0006886 intracellular protein transport TAS
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006914 autophagy ISO
 biological_processGO:0007030 Golgi organization IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0019068 virion assembly IEA
 biological_processGO:0030252 growth hormone secretion IEA
 biological_processGO:0032402 melanosome transport IMP
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IMP
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0047496 vesicle transport along microtubule IEA
 biological_processGO:0072606 interleukin-8 secretion IEA
 biological_processGO:0090110 cargo loading into COPII-coated vesicle IEA
 biological_processGO:1903020 positive regulation of glycoprotein metabolic process IEA
 cellular_componentGO:0000139 Golgi membrane IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IBA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0042470 melanosome IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
Golgi Cisternae Pericentriolar Stack Reorganization
COPII-mediated vesicle transport
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001052 Sec24b / Sec24 related gene family, member B (S. cerevisiae) / O95487* / SEC24 homolog B, COPII coat complex component*  / complex / reaction
 ENSMUSG00000015291 Gdi1 / P50396 / Rab GDP dissociation inhibitor alpha / P31150* / GDP dissociation inhibitor 1*  / complex
 ENSMUSG00000025162 Csnk1d / Q9DC28 / casein kinase 1, delta / P48730*  / reaction
 ENSMUSG00000030867 Plk1 / Q07832 / polo like kinase 1 / P53350*  / complex
 ENSMUSG00000029407 Uso1 / Q9Z1Z0 / USO1 vesicle docking factor / O60763* / USO1 vesicle transport factor*  / complex / reaction
 ENSMUSG00000032513 Q91X51 / Gorasp1 / golgi reassembly stacking protein 1 / Q9BQQ3*  / complex / reaction
 ENSMUSG00000002546 Golga2 / Q921M4 / golgi autoantigen, golgin subfamily a, 2 / A7E2F4* / A8MQT2* / D6RF30* / F8WBI6* / A6NCC3* / A6NDK9* / A6NDN3* / A6NMD2* / H3BSY2* / I6L899* / P0CG33* / P0CJ92* / Q08379* ...  / complex / reaction
 ENSMUSG00000020986 Q01405 / Sec23a / Protein transport protein Sec23A / Q15436* / Sec23 homolog A, coat complex II component*  / complex / reaction
 ENSMUSG00000025531 Chm / choroidermia (RAB escort protein 1) / P24386* / CHM, Rab escort protein 1*  / complex
 ENSMUSG00000027879 O08547 / Sec22b / Vesicle-trafficking protein SEC22b / O75396* / SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)*  / complex / reaction
 ENSMUSG00000030298 Sec13 / Q9D1M0 / SEC13 homolog, nuclear pore and COPII coat complex component / P55735*  / complex / reaction
 ENSMUSG00000055319 Sec23ip / Sec23 interacting protein / Q9Y6Y8*  / complex / reaction
 ENSMUSG00000036391 Q3U2P1 / Sec24a / Protein transport protein Sec24A / O95486* / SEC24 homolog A, COPII coat complex component*  / complex / reaction
 ENSMUSG00000039234 Sec24d / Sec24 related gene family, member D (S. cerevisiae) / O94855* / SEC24 homolog D, COPII coat complex component*  / complex / reaction
 ENSMUSG00000021218 Gdi2 / Q61598 / Rab GDP dissociation inhibitor beta / P50395* / GDP dissociation inhibitor 2*  / complex
 ENSMUSG00000035325 Q3UPL0 / Sec31a / Protein transport protein Sec31A / O94979* / SEC31 homolog A, COPII coat complex component*  / complex / reaction
 ENSMUSG00000078185 Chml / choroideremia-like / P26374* / CHM like, Rab escort protein 2*  / complex






 

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