Manteia - Molecule gene

ENSMUSG00000029407

Mus musculus

Features

Gene ID:	ENSMUSG00000029407

Biological name :	Uso1

Synonyms :	Q9Z1Z0 / Uso1 / USO1 vesicle docking factor

Possible biological names infered from orthology :	O60763 / USO1 vesicle transport factor

Species:	Mus musculus

Chr. number:	5
Strand:	1
Band:	E2
Gene start:	92137938
Gene end:	92202798

Corresponding Affymetrix probe sets:	10523206 (MoGene1.0st) 1424274_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000031355 Ensembl peptide - ENSMUSP00000144165 Ensembl peptide - ENSMUSP00000144592 NCBI entrez gene - 56041 See in Manteia. MGI - MGI:1929095 RefSeq - XM_017321009 RefSeq - NM_019490 RefSeq - XM_006535140 RefSeq - XM_006535141 RefSeq Peptide - NP_062363 swissprot - A0A0J9YUG0 swissprot - Q9Z1Z0 Ensembl - ENSMUSG00000029407

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
uso1	ENSDARG00000019581	Danio rerio
USO1	ENSGALG00000010878	Gallus gallus
USO1	ENSG00000138768	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR000225	Armadillo
IPR006953	Vesicle tethering protein Uso1/P115-like , head domain
IPR006955	Uso1/p115-like vesicle tethering protein, C-terminal
IPR011989	Armadillo-like helical
IPR016024	Armadillo-type fold

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006886	intracellular protein transport	IDA
biological_process	GO:0006888	ER to Golgi vesicle-mediated transport	IBA
biological_process	GO:0007030	Golgi organization	IMP
biological_process	GO:0015031	protein transport	IEA
biological_process	GO:0016192	vesicle-mediated transport	IEA
biological_process	GO:0045056	transcytosis	IBA
biological_process	GO:0048211	Golgi vesicle docking	IBA
biological_process	GO:0048280	vesicle fusion with Golgi apparatus	IEA
biological_process	GO:0061025	membrane fusion	IBA
cellular_component	GO:0000139	Golgi membrane	IEA
cellular_component	GO:0001650	fibrillar center	ISO
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005783	endoplasmic reticulum	IBA
cellular_component	GO:0005794	Golgi apparatus	ISO
cellular_component	GO:0005795	Golgi stack	IBA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0012507	ER to Golgi transport vesicle membrane	IBA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0048471	perinuclear region of cytoplasm	IDA
molecular_function	GO:0005488	binding	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008565	protein transporter activity	IDA
molecular_function	GO:0045296	cadherin binding	ISO

Pathways (from Reactome)

Pathway description

COPII-mediated vesicle transport

COPI-mediated anterograde transport

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0011092	complete embryonic lethality	"death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]	Show Allelic Composition: Sppl2a^m1Anu/Sppl2a^m1Anu Genetic Background: involves: C57BL/6JAnu Allelic Composition: Uso1^{Gt(YTA025)Byg}/Uso1^{Gt(YTA025)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011743	abnormal Golgi apparatus morphology	"any structural anomaly of the compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack; Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations" [GO:0005794, MGI:mberry]	Show Allelic Composition: Sppl2a^m1Anu/Sppl2a^m1Anu Genetic Background: involves: C57BL/6JAnu Allelic Composition: Uso1^{Gt(YTA025)Byg}/Uso1^{Gt(YTA025)Byg} Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000001052	Sec24b / Sec24 related gene family, member B (S. cerevisiae) / O95487* / SEC24 homolog B, COPII coat complex component*	/ complex / reaction
ENSMUSG00000018672	Copz2 / Q9JHH9 / Coatomer subunit zeta-2 / Q9P299* / coatomer protein complex subunit zeta 2*	/ complex / reaction
ENSMUSG00000025162	Csnk1d / Q9DC28 / casein kinase 1, delta / P48730*	/ reaction
ENSMUSG00000010110	Stx5a / Q8K1E0 / Syntaxin-5 / STX5* / Q13190*	/ reaction
ENSMUSG00000020149	Rab1 / P62821 / Ras-related protein Rab-1A / RAB1A* / P62820* / RAB1A, member RAS oncogene family*	/ complex / reaction
ENSMUSG00000026553	Copa / Q8CIE6 / Coatomer subunit alpha Xenin Proxenin / P53621* / coatomer protein complex subunit alpha*	/ complex / reaction
ENSMUSG00000020952	Scfd1 / Q8BRF7 / Sec1 family domain-containing protein 1 / Q8WVM8* / sec1 family domain containing 1*	/ reaction
ENSMUSG00000024870	Rab1b / Q9D1G1 / RAB1B, member RAS oncogene family / Q9H0U4*	/ complex / reaction
ENSMUSG00000020986	Q01405 / Sec23a / Protein transport protein Sec23A / Q15436* / Sec23 homolog A, coat complex II component*	/ complex / reaction
ENSMUSG00000021877	Arf4 / P61750 / ADP-ribosylation factor 4 / P18085*	/ complex / reaction
ENSMUSG00000020946	Gosr2 / O35166 / golgi SNAP receptor complex member 2 / O14653* / AC005670.2*	/ reaction
ENSMUSG00000027879	O08547 / Sec22b / Vesicle-trafficking protein SEC22b / O75396* / SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)*	/ complex / reaction
ENSMUSG00000029407	Uso1 / Q9Z1Z0 / USO1 vesicle docking factor / O60763* / USO1 vesicle transport factor*	/ complex
ENSMUSG00000032096	Arcn1 / Q5XJY5 / Coatomer subunit delta / P48444* / archain 1*	/ complex / reaction
ENSMUSG00000032513	Q91X51 / Gorasp1 / golgi reassembly stacking protein 1 / Q9BQQ3*	/ complex / reaction
ENSMUSG00000032458	Copb2 / O55029 / Coatomer subunit beta / P35606* / coatomer protein complex subunit beta 2*	/ complex / reaction
ENSMUSG00000030754	Copb1 / Q9JIF7 / Coatomer subunit beta / P53618* / coatomer protein complex subunit beta 1*	/ complex / reaction
ENSMUSG00000055681	Cope / O89079 / Coatomer subunit epsilon / O14579* / coatomer protein complex subunit epsilon*	/ complex / reaction
ENSMUSG00000025607	Copg2 / Q9QXK3 / Coatomer subunit gamma-2 / Q9UBF2* / coatomer protein complex subunit gamma 2*	/ complex / reaction
ENSMUSG00000030058	Copg1 / Q9QZE5 / Coatomer subunit gamma-1 / Q9Y678* / coatomer protein complex subunit gamma 1*	/ complex / reaction
ENSMUSG00000002546	Golga2 / Q921M4 / golgi autoantigen, golgin subfamily a, 2 / A7E2F4* / A8MQT2* / D6RF30* / F8WBI6* / A6NCC3* / A6NDK9* / A6NDN3* / A6NMD2* / H3BSY2* / I6L899* / P0CG33* / P0CJ92* / Q08379* ...	/ complex / reaction
ENSMUSG00000060992	Copz1 / P61924 / Coatomer subunit zeta-1 / P61923* / coatomer protein complex subunit zeta 1*	/ complex / reaction
ENSMUSG00000030298	Sec13 / Q9D1M0 / SEC13 homolog, nuclear pore and COPII coat complex component / P55735*	/ complex / reaction
ENSMUSG00000055319	Sec23ip / Sec23 interacting protein / Q9Y6Y8*	/ complex / reaction
ENSMUSG00000036391	Q3U2P1 / Sec24a / Protein transport protein Sec24A / O95486* / SEC24 homolog A, COPII coat complex component*	/ complex / reaction
ENSMUSG00000039234	Sec24d / Sec24 related gene family, member D (S. cerevisiae) / O94855* / SEC24 homolog D, COPII coat complex component*	/ complex / reaction
ENSMUSG00000032757	Bet1 / O35623 / BET1 homolog / O15155* / Bet1 golgi vesicular membrane trafficking protein*	/ reaction
ENSMUSG00000035325	Q3UPL0 / Sec31a / Protein transport protein Sec31A / O94979* / SEC31 homolog A, COPII coat complex component*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr