ENSMUSG00000027879


Mus musculus

Features
Gene ID: ENSMUSG00000027879
  
Biological name :Sec22b
  
Synonyms : O08547 / Sec22b / Vesicle-trafficking protein SEC22b
  
Possible biological names infered from orthology : O75396 / SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.2
Gene start: 97901190
Gene end: 97923276
  
Corresponding Affymetrix probe sets: 10494583 (MoGene1.0st)   10343811 (MoGene1.0st)   1415766_at (Mouse Genome 430 2.0 Array)   1449063_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029476
Ensembl peptide - ENSMUSP00000142976
Ensembl peptide - ENSMUSP00000117579
Ensembl peptide - ENSMUSP00000113502
NCBI entrez gene - 20333     See in Manteia.
MGI - MGI:1338759
RefSeq - NM_011342
RefSeq Peptide - NP_035472
swissprot - D6RES2
swissprot - A0A0G2JF08
swissprot - E9Q6R3
swissprot - O08547
Ensembl - ENSMUSG00000027879
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q7SXP0ENSDARG00000100435Danio rerio
 sec22baENSDARG00000030108Danio rerio
 Q5ZJW4ENSGALG00000039704Gallus gallus
 O75396ENSG00000265808Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BH47 / Sec22a / SEC22 homolog A, vesicle trafficking protein / Q96IW7*ENSMUSG0000003447333
Q8BXT9 / Sec22c / Vesicle-trafficking protein SEC22c / Q9BRL7* / SEC22 homolog C, vesicle trafficking protein*ENSMUSG0000006153625


Protein motifs (from Interpro)
Interpro ID Name
 IPR001388  Synaptobrevin
 IPR010908  Longin domain
 IPR011012  Longin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0048280 vesicle fusion with Golgi apparatus IBA
 biological_processGO:1902902 negative regulation of autophagosome assembly IEA
 cellular_componentGO:0000139 Golgi membrane IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IDA
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0012507 ER to Golgi transport vesicle membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031201 SNARE complex IBA
 cellular_componentGO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane IEA
 cellular_componentGO:0042470 melanosome IEA
 molecular_functionGO:0000149 SNARE binding IBA
 molecular_functionGO:0005484 SNAP receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019905 syntaxin binding IEA


Pathways (from Reactome)
Pathway description
ER-Phagosome pathway
COPII-mediated vesicle transport
Cargo concentration in the ER
COPI-dependent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1l+
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ralatm1a(EUCOMM)Wtsi/Ralatm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ralatm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001052 Sec24b / Sec24 related gene family, member B (S. cerevisiae) / O95487* / SEC24 homolog B, COPII coat complex component*  / complex / reaction
 ENSMUSG00000006024 Napa / Q9DB05 / Alpha-soluble NSF attachment protein / P54920* / NSF attachment protein alpha*  / complex / reaction
 ENSMUSG00000003814 Calr / P14211 / Calreticulin / P27797*  / reaction
 ENSMUSG00000020386 Sar1b / Q9CQC9 / secretion associated Ras related GTPase 1B / Q9Y6B6*  / complex / reaction
 ENSMUSG00000025162 Csnk1d / Q9DC28 / casein kinase 1, delta / P48730*  / reaction
 ENSMUSG00000024191 Bnip1 / Q6QD59 / Vesicle transport protein SEC20 / Q12981* / BCL2 interacting protein 1*  / complex
 ENSMUSG00000010110 Stx5a / Q8K1E0 / Syntaxin-5 / STX5* / Q13190*  / complex / reaction
 ENSMUSG00000002395 Use1 / Q9CQ56 / unconventional SNARE in the ER 1 homolog (S. cerevisiae) / Q9NZ43* / unconventional SNARE in the ER 1*  / complex
 ENSMUSG00000020952 Scfd1 / Q8BRF7 / Sec1 family domain-containing protein 1 / Q8WVM8* / sec1 family domain containing 1*  / complex / reaction
 ENSMUSG00000020986 Q01405 / Sec23a / Protein transport protein Sec23A / Q15436* / Sec23 homolog A, coat complex II component*  / complex / reaction
 ENSMUSG00000026589 Q91XT4 / Sec16b / Protein transport protein Sec16B / Q96JE7* / SEC16 homolog B, endoplasmic reticulum export factor*  / complex / reaction
 ENSMUSG00000020946 Gosr2 / O35166 / golgi SNAP receptor complex member 2 / O14653* / AC005670.2*  / complex / reaction
 ENSMUSG00000024308 Tapbp / TAP binding protein / O15533*  / reaction
 ENSMUSG00000029125 Stx18 / Q8VDS8 / Syntaxin-18 / Q9P2W9*  / complex
 ENSMUSG00000020149 Rab1 / P62821 / Ras-related protein Rab-1A / RAB1A* / P62820* / RAB1A, member RAS oncogene family*  / complex / reaction
 ENSMUSG00000024339 Tap2 / P36371 / transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) / Q03519* / AL669918.1* / transporter 2, ATP binding cassette subfamily B member*  / reaction
 ENSMUSG00000030805 Stx4a / P70452 / Syntaxin-4 / STX4* / Q12846*  / complex
 ENSMUSG00000029407 Uso1 / Q9Z1Z0 / USO1 vesicle docking factor / O60763* / USO1 vesicle transport factor*  / complex / reaction
 ENSMUSG00000034187 Nsf / P46460 / Vesicle-fusing ATPase / P46459* / N-ethylmaleimide sensitive factor, vesicle fusing ATPase*  / complex / reaction
 ENSMUSG00000032513 Q91X51 / Gorasp1 / golgi reassembly stacking protein 1 / Q9BQQ3*  / complex / reaction
 ENSMUSG00000037321 Tap1 / P21958 / transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) / Q03518* / transporter 1, ATP binding cassette subfamily B member*  / reaction
 ENSMUSG00000002546 Golga2 / Q921M4 / golgi autoantigen, golgin subfamily a, 2 / A7E2F4* / A8MQT2* / D6RF30* / F8WBI6* / A6NCC3* / A6NDK9* / A6NDN3* / A6NMD2* / H3BSY2* / I6L899* / P0CG33* / P0CJ92* / Q08379* ...  / complex / reaction
 ENSMUSG00000030298 Sec13 / Q9D1M0 / SEC13 homolog, nuclear pore and COPII coat complex component / P55735*  / complex / reaction
 ENSMUSG00000055319 Sec23ip / Sec23 interacting protein / Q9Y6Y8*  / complex / reaction
 ENSMUSG00000036391 Q3U2P1 / Sec24a / Protein transport protein Sec24A / O95486* / SEC24 homolog A, COPII coat complex component*  / complex / reaction
 ENSMUSG00000039234 Sec24d / Sec24 related gene family, member D (S. cerevisiae) / O94855* / SEC24 homolog D, COPII coat complex component*  / complex / reaction
 ENSMUSG00000032757 Bet1 / O35623 / BET1 homolog / O15155* / Bet1 golgi vesicular membrane trafficking protein*  / complex / reaction
 ENSMUSG00000026924 Sec16a / SEC16 homolog A, endoplasmic reticulum export factor / O15027*  / complex / reaction
 ENSMUSG00000035325 Q3UPL0 / Sec31a / Protein transport protein Sec31A / O94979* / SEC31 homolog A, COPII coat complex component*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr