ENSMUSG00000039234


Mus musculus

Features
Gene ID: ENSMUSG00000039234
  
Biological name :Sec24d
  
Synonyms : Sec24d / Sec24 related gene family, member D (S. cerevisiae)
  
Possible biological names infered from orthology : O94855 / SEC24 homolog D, COPII coat complex component
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: G1
Gene start: 123267455
Gene end: 123365641
  
Corresponding Affymetrix probe sets: 10495830 (MoGene1.0st)   1426972_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143588
Ensembl peptide - ENSMUSP00000035823
NCBI entrez gene - 69608     See in Manteia.
MGI - MGI:1916858
RefSeq - NM_027135
RefSeq - XM_006502038
RefSeq Peptide - NP_081411
swissprot - A0A0G2JGJ5
swissprot - Q6NXL1
Ensembl - ENSMUSG00000039234
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sec24dENSDARG00000045946Danio rerio
 SEC24DENSGALG00000011998Gallus gallus
 O94855ENSG00000150961Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sec24c / Sec24 related gene family, member C (S. cerevisiae) / P53992* / SEC24 homolog C, COPII coat complex component*ENSMUSG0000003936757
Sec24b / Sec24 related gene family, member B (S. cerevisiae) / O95487* / SEC24 homolog B, COPII coat complex component*ENSMUSG0000000105227
Q3U2P1 / Sec24a / Protein transport protein Sec24A / O95486* / SEC24 homolog A, COPII coat complex component*ENSMUSG0000003639125


Protein motifs (from Interpro)
Interpro ID Name
 IPR006895  Zinc finger, Sec23/Sec24-type
 IPR006896  Sec23/Sec24, trunk domain
 IPR006900  Sec23/Sec24, helical domain
 IPR007123  Gelsolin-like domain
 IPR012990  Sec23/Sec24 beta-sandwich
 IPR029006  ADF-H/Gelsolin-like domain superfamily
 IPR036175  Sec23/Sec24 helical domain superfamily
 IPR036180  Gelsolin-like domain superfamily
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport ISO
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0090110 cargo loading into COPII-coated vesicle ISO
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0030127 COPII vesicle coat ISO
 molecular_functionGO:0000149 SNARE binding ISO
 molecular_functionGO:0008270 zinc ion binding ISO


Pathways (from Reactome)
Pathway description
COPII-mediated vesicle transport
MHC class II antigen presentation
Cargo concentration in the ER
Antigen Presentation: Folding, assembly and peptide loading of class I MHC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Erfetm1Lex/Erfetm1Lex,Hbb-b1tm1Unc/Hbb-b1+,Hbb-b2tm1Unc/Hbb-b2+
Genetic Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6

Allelic Composition: Sec24ctm1d(EUCOMM)Wtsi/Sec24c+,Sec24dGt(RRT226)Byg/Sec24d+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N * FVB/N

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: Car5atm1Sly/Car5atm1Sly,Car5btm1Sly/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Car5atm1Sly/Car5atm1Sly,Car5btm1Sly/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020386 Sar1b / Q9CQC9 / secretion associated Ras related GTPase 1B / Q9Y6B6*  / complex / reaction
 ENSMUSG00000025162 Csnk1d / Q9DC28 / casein kinase 1, delta / P48730*  / reaction
 ENSMUSG00000010110 Stx5a / Q8K1E0 / Syntaxin-5 / STX5* / Q13190*  / complex / reaction
 ENSMUSG00000020986 Q01405 / Sec23a / Protein transport protein Sec23A / Q15436* / Sec23 homolog A, coat complex II component*  / complex / reaction
 ENSMUSG00000020946 Gosr2 / O35166 / golgi SNAP receptor complex member 2 / O14653* / AC005670.2*  / complex / reaction
 ENSMUSG00000026753 Ppp6c / Q9CQR6 / Serine/threonine-protein phosphatase 6 catalytic subunit / O00743* / protein phosphatase 6 catalytic subunit*  / reaction
 ENSMUSG00000036594 H2-Aa / P14434 / H-2 class II histocompatibility antigen, A-B alpha chain / P01909* / P01906* / HLA-DQA2* / HLA-DQA1* / major histocompatibility complex, class II, DQ alpha 2* / major hist...  / complex / reaction
 ENSMUSG00000030298 Sec13 / Q9D1M0 / SEC13 homolog, nuclear pore and COPII coat complex component / P55735*  / complex / reaction
 ENSMUSG00000055319 Sec23ip / Sec23 interacting protein / Q9Y6Y8*  / complex / reaction
 ENSMUSG00000073421 H2-Ab1 / P14483 / histocompatibility 2, class II antigen A, beta 1 / P05538* / HLA-DQB1* / HLA-DQB2* / major histocompatibility complex, class II, DQ beta 1* / major histocompatibility comp...  / complex / reaction
 ENSMUSG00000024610 Cd74 / P04441 / CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) / P04233* / CD74 molecule*  / complex / reaction
 ENSMUSG00000067341 H2-Eb2 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / complex / reaction
 ENSMUSG00000020149 Rab1 / P62821 / Ras-related protein Rab-1A / RAB1A* / P62820* / RAB1A, member RAS oncogene family*  / complex / reaction
 ENSMUSG00000026589 Q91XT4 / Sec16b / Protein transport protein Sec16B / Q96JE7* / SEC16 homolog B, endoplasmic reticulum export factor*  / complex / reaction
 ENSMUSG00000027879 O08547 / Sec22b / Vesicle-trafficking protein SEC22b / O75396* / SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)*  / complex / reaction
 ENSMUSG00000029407 Uso1 / Q9Z1Z0 / USO1 vesicle docking factor / O60763* / USO1 vesicle transport factor*  / complex / reaction
 ENSMUSG00000032513 Q91X51 / Gorasp1 / golgi reassembly stacking protein 1 / Q9BQQ3*  / complex / reaction
 ENSMUSG00000026924 Sec16a / SEC16 homolog A, endoplasmic reticulum export factor / O15027*  / complex / reaction
 ENSMUSG00000035325 Q3UPL0 / Sec31a / Protein transport protein Sec31A / O94979* / SEC31 homolog A, COPII coat complex component*  / complex / reaction
 ENSMUSG00000002546 Golga2 / Q921M4 / golgi autoantigen, golgin subfamily a, 2 / A7E2F4* / A8MQT2* / D6RF30* / F8WBI6* / A6NCC3* / A6NDK9* / A6NDN3* / A6NMD2* / H3BSY2* / I6L899* / P0CG33* / P0CJ92* / Q08379* ...  / complex / reaction
 ENSMUSG00000060586 H2-Eb1 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / reaction / complex
 ENSMUSG00000060802 B2m / P01887 / Beta-2-microglobulin / P61769*  / complex / reaction






 

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