ENSG00000182968


Homo sapiens

Features
Gene ID: ENSG00000182968
  
Biological name :SOX1
  
Synonyms : O00570 / SOX1 / SRY-box 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: 1
Band: q34
Gene start: 112067647
Gene end: 112070488
  
Corresponding Affymetrix probe sets: 208533_at (Human Genome U133 Plus 2.0 Array)   230982_at (Human Genome U133 Plus 2.0 Array)   237472_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000330218
NCBI entrez gene - 6656     See in Manteia.
OMIM - 602148
RefSeq - NM_005986
RefSeq Peptide - NP_005977
swissprot - O00570
Ensembl - ENSG00000182968
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sox1aENSDARG00000069866Danio rerio
 sox1bENSDARG00000008131Danio rerio
 SOX1ENSGALG00000030353Gallus gallus
 Sox1ENSMUSG00000096014Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SOX3 / P41225 / SRY-box 3ENSG0000013459556
SOX2 / P48431 / SRY-box 2ENSG0000018144949
SOX21 / Q9Y651 / SRY-box 21ENSG0000012528529
SOX14 / O95416 / SRY-box 14ENSG0000016887527
SOX15 / O60248 / SRY-box 15ENSG0000012919425
SOX18 / P35713 / SRY-box 18ENSG0000020388322
SOX17 / Q9H6I2 / SRY-box 17ENSG0000016473621
SOX7 / Q9BT81 / SRY-box 7ENSG0000017105621
SOX10 / P56693 / SRY-box 10ENSG0000010014620
SOX4 / Q06945 / SRY-box 4ENSG0000012476620
SOX9 / P48436 / SRY-box 9ENSG0000012539820
SOX11 / P35716 / SRY-box 11ENSG0000017688720
SOX8 / P57073 / SRY-box 8ENSG0000000551319
SRY / Q05066 / sex determining region YENSG0000018489519
AC105001.2ENSG0000025872417
SOX12 / O15370 / SRY-box 12ENSG0000017773216


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR022097  Transcription factor SOX
 IPR031268  Transcription factor SOX-1
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0002089 lens morphogenesis in camera-type eye IEA
 biological_processGO:0006325 chromatin organization NAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated NAS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0021521 ventral spinal cord interneuron specification IEA
 biological_processGO:0021879 forebrain neuron differentiation IEA
 biological_processGO:0021884 forebrain neuron development IEA
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 cellular_componentGO:0005634 nucleus NAS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding NAS
 molecular_functionGO:0003700 DNA-binding transcription factor activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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