ENSG00000197894


Homo sapiens

Features
Gene ID: ENSG00000197894
  
Biological name :ADH5
  
Synonyms : ADH5 / alcohol dehydrogenase 5 (class III), chi polypeptide / P11766
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q23
Gene start: 99070978
Gene end: 99088801
  
Corresponding Affymetrix probe sets: 208847_s_at (Human Genome U133 Plus 2.0 Array)   208848_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000427049
Ensembl peptide - ENSP00000421556
Ensembl peptide - ENSP00000487496
Ensembl peptide - ENSP00000422119
Ensembl peptide - ENSP00000424650
Ensembl peptide - ENSP00000296412
NCBI entrez gene - 128     See in Manteia.
OMIM - 103710
RefSeq - NM_000671
RefSeq Peptide - NP_000662
swissprot - D6R9G2
swissprot - H0YAG8
swissprot - P11766
swissprot - D6RFE4
swissprot - Q6IRT1
swissprot - D6RAY0
Ensembl - ENSG00000197894
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adh5ENSDARG00000080010Danio rerio
 adh8aENSDARG00000091211Danio rerio
 adh8bENSDARG00000024278Danio rerio
 zgc:63568ENSDARG00000087262Danio rerio
 zgc:77938ENSDARG00000088366Danio rerio
 ADH5ENSGALG00000012245Gallus gallus
 Adh5ENSMUSG00000028138Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADH1A / P07327 / alcohol dehydrogenase 1A (class I), alpha polypeptideENSG0000018775863
ADH1B / P00325 / alcohol dehydrogenase 1B (class I), beta polypeptideENSG0000019661663
ADH1C / P00326 / alcohol dehydrogenase 1C (class I), gamma polypeptideENSG0000024814463
ADH4 / P08319 / alcohol dehydrogenase 4 (class II), pi polypeptideENSG0000019809962
ADH7 / P40394 / alcohol dehydrogenase 7 (class IV), mu or sigma polypeptideENSG0000019634461
ADH6 / P28332 / alcohol dehydrogenase 6 (class V)ENSG0000017295558


Protein motifs (from Interpro)
Interpro ID Name
 IPR002328  Alcohol dehydrogenase, zinc-type, conserved site
 IPR011032  GroES-like superfamily
 IPR013149  Alcohol dehydrogenase, C-terminal
 IPR013154  Alcohol dehydrogenase, N-terminal
 IPR014183  Alcohol dehydrogenase class III
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001523 retinoid metabolic process IEA
 biological_processGO:0003016 respiratory system process IEA
 biological_processGO:0006069 ethanol oxidation TAS
 biological_processGO:0018119 peptidyl-cysteine S-nitrosylation IEA
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0045777 positive regulation of blood pressure IEA
 biological_processGO:0046294 formaldehyde catabolic process IEA
 biological_processGO:0051409 response to nitrosative stress IEA
 biological_processGO:0051775 response to redox state IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004022 alcohol dehydrogenase (NAD) activity IEA
 molecular_functionGO:0005504 fatty acid binding IDA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0009055 electron transfer activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0018467 formaldehyde dehydrogenase activity IDA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051903 S-(hydroxymethyl)glutathione dehydrogenase activity TAS


Pathways (from Reactome)
Pathway description
Ethanol oxidation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000197894 ADH5 / P11766 / alcohol dehydrogenase 5 (class III), chi polypeptide  / complex






 

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