ENSG00000198099


Homo sapiens

Features
Gene ID: ENSG00000198099
  
Biological name :ADH4
  
Synonyms : ADH4 / alcohol dehydrogenase 4 (class II), pi polypeptide / P08319
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q23
Gene start: 99123657
Gene end: 99157792
  
Corresponding Affymetrix probe sets: 223781_x_at (Human Genome U133 Plus 2.0 Array)   231675_s_at (Human Genome U133 Plus 2.0 Array)   231678_s_at (Human Genome U133 Plus 2.0 Array)   231703_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000424630
Ensembl peptide - ENSP00000425416
Ensembl peptide - ENSP00000486450
Ensembl peptide - ENSP00000427525
Ensembl peptide - ENSP00000427261
Ensembl peptide - ENSP00000426667
Ensembl peptide - ENSP00000265512
Ensembl peptide - ENSP00000423571
Ensembl peptide - ENSP00000424583
NCBI entrez gene - 127     See in Manteia.
OMIM - 103740
RefSeq - XM_017007715
RefSeq - NM_000670
RefSeq - NM_001306171
RefSeq - NM_001306172
RefSeq - XM_017007713
RefSeq - XM_017007714
RefSeq Peptide - NP_000661
RefSeq Peptide - NP_001293100
RefSeq Peptide - NP_001293101
swissprot - D6R9K8
swissprot - A0A0D9SFB5
swissprot - H0Y9N0
swissprot - D6RF43
swissprot - D6RIB1
swissprot - P08319
Ensembl - ENSG00000198099
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adh5ENSDARG00000080010Danio rerio
 adh8aENSDARG00000091211Danio rerio
 adh8bENSDARG00000024278Danio rerio
 zgc:63568ENSDARG00000087262Danio rerio
 zgc:77938ENSDARG00000088366Danio rerio
 Adh4ENSMUSG00000037797Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADH5 / P11766 / alcohol dehydrogenase 5 (class III), chi polypeptideENSG0000019789458
ADH1B / P00325 / alcohol dehydrogenase 1B (class I), beta polypeptideENSG0000019661657
ADH1A / P07327 / alcohol dehydrogenase 1A (class I), alpha polypeptideENSG0000018775856
ADH1C / P00326 / alcohol dehydrogenase 1C (class I), gamma polypeptideENSG0000024814456
ADH6 / P28332 / alcohol dehydrogenase 6 (class V)ENSG0000017295555
ADH7 / P40394 / alcohol dehydrogenase 7 (class IV), mu or sigma polypeptideENSG0000019634454


Protein motifs (from Interpro)
Interpro ID Name
 IPR002328  Alcohol dehydrogenase, zinc-type, conserved site
 IPR011032  GroES-like superfamily
 IPR013149  Alcohol dehydrogenase, C-terminal
 IPR013154  Alcohol dehydrogenase, N-terminal
 IPR020843  Polyketide synthase, enoylreductase domain
 IPR028632  Alcohol dehydrogenase family, zinc-type, class-II subfamily
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001523 retinoid metabolic process IDA
 biological_processGO:0006066 alcohol metabolic process IDA
 biological_processGO:0006067 ethanol metabolic process IEA
 biological_processGO:0006069 ethanol oxidation IEA
 biological_processGO:0006081 cellular aldehyde metabolic process IDA
 biological_processGO:0042572 retinol metabolic process IDA
 biological_processGO:0046164 alcohol catabolic process ISS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:1901661 quinone metabolic process ISS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0003960 NADPH:quinone reductase activity ISS
 molecular_functionGO:0004022 alcohol dehydrogenase (NAD) activity IEA
 molecular_functionGO:0004024 alcohol dehydrogenase activity, zinc-dependent IEA
 molecular_functionGO:0004032 alditol:NADP+ 1-oxidoreductase activity IEA
 molecular_functionGO:0004745 retinol dehydrogenase activity TAS
 molecular_functionGO:0005503 all-trans retinal binding IDA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IDA
 molecular_functionGO:0019115 benzaldehyde dehydrogenase activity IDA
 molecular_functionGO:0019841 retinol binding IDA
 molecular_functionGO:0035276 ethanol binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051287 NAD binding IDA


Pathways (from Reactome)
Pathway description
RA biosynthesis pathway
Ethanol oxidation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000198099 ADH4 / P08319 / alcohol dehydrogenase 4 (class II), pi polypeptide  / complex






 

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