ENSG00000203857


Homo sapiens

Features
Gene ID: ENSG00000203857
  
Biological name :HSD3B1
  
Synonyms : HSD3B1 / hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 / P14060
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p12
Gene start: 119507198
Gene end: 119515054
  
Corresponding Affymetrix probe sets: 204515_at (Human Genome U133 Plus 2.0 Array)   241111_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000435999
Ensembl peptide - ENSP00000358421
Ensembl peptide - ENSP00000432268
NCBI entrez gene - 3283     See in Manteia.
OMIM - 109715
RefSeq - XM_017001119
RefSeq - NM_000862
RefSeq - NM_001328615
RefSeq - XM_011541314
RefSeq Peptide - NP_001315544
RefSeq Peptide - NP_000853
swissprot - P14060
swissprot - E9PRN7
Ensembl - ENSG00000203857
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hsd3b1ENSDARG00000069926Danio rerio
 hsd3b2ENSDARG00000019747Danio rerio
 HSD3B1ENSGALG00000037951Gallus gallus
 Gm4450ENSMUSG00000090817Mus musculus
 Hsd3b1ENSMUSG00000027871Mus musculus
 Hsd3b2ENSMUSG00000063730Mus musculus
 Hsd3b3ENSMUSG00000062410Mus musculus
 Hsd3b4ENSMUSG00000095143Mus musculus
 Hsd3b5ENSMUSG00000038092Mus musculus
 Hsd3b6ENSMUSG00000027869Mus musculus
 Q61767ENSMUSG00000095388Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HSD3B2 / P26439 / hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2ENSG0000020385993
HSD3B7 / Q9H2F3 / hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7ENSG0000009937737
Q8WUS8 / SDR42E1 / short chain dehydrogenase/reductase family 42E, member 1ENSG0000018486029
A6NKP2 / SDR42E2 / short chain dehydrogenase/reductase family 42E, member 2ENSG0000018392128
NSDHL / Q15738 / NAD(P) dependent steroid dehydrogenase-likeENSG0000014738325


Protein motifs (from Interpro)
Interpro ID Name
 IPR002225  3-beta hydroxysteroid dehydrogenase/isomerase
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006694 steroid biosynthetic process TAS
 biological_processGO:0006702 androgen biosynthetic process TAS
 biological_processGO:0006703 estrogen biosynthetic process TAS
 biological_processGO:0006704 glucocorticoid biosynthetic process TAS
 biological_processGO:0006705 mineralocorticoid biosynthetic process TAS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005758 mitochondrial intermembrane space IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030868 smooth endoplasmic reticulum membrane ISS
 cellular_componentGO:0031966 mitochondrial membrane IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity TAS
 molecular_functionGO:0004769 steroid delta-isomerase activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0102294 cholesterol dehydrogenase activity IEA


Pathways (from Reactome)
Pathway description
Androgen biosynthesis
Mineralocorticoid biosynthesis
Glucocorticoid biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000203857 HSD3B1 / P14060 / hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1  / complex






 

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