ENSGALG00000003805


Gallus gallus

Features
Gene ID: ENSGALG00000003805
  
Biological name :PRKG1
  
Synonyms : PRKG1 / protein kinase, cGMP-dependent, type I
  
Possible biological names infered from orthology : P0C605 / Q13976
  
Species: Gallus gallus
  
Chr. number: 6
Strand: 1
Band:
Gene start: 9868124
Gene end: 10254176
  
Corresponding Affymetrix probe sets: GgaAffx.25990.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000053377
Ensembl peptide - ENSGALP00000006027
NCBI entrez gene - 423682     See in Manteia.
RefSeq - XM_015278708
RefSeq - XM_003641459
RefSeq - XM_015278706
swissprot - F1NE85
swissprot - A0A1D5PKL6
Ensembl - ENSGALG00000003805
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkg1bENSDARG00000031702Danio rerio
 PRKG1ENSG00000185532Homo sapiens
 Prkg1ENSMUSG00000052920Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRKG2 / protein kinase, cGMP-dependent, type II / Q13237*ENSGALG0000001090947
ENSGALG0000004254330
PRKACB / protein kinase cAMP-activated catalytic subunit beta / P22694* / P68181* / protein kinase, cAMP dependent, catalytic, beta*ENSGALG0000002853021
PRKX / protein kinase, X-linked / P51817* / Q922R0* / cAMP-dependent protein kinase catalytic subunit PRKX *ENSGALG0000004275920


Protein motifs (from Interpro)
Interpro ID Name
 IPR000595  Cyclic nucleotide-binding domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002374  cGMP-dependent kinase
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014710  RmlC-like jelly roll fold
 IPR017441  Protein kinase, ATP binding site
 IPR018488  Cyclic nucleotide-binding, conserved site
 IPR018490  Cyclic nucleotide-binding-like
 IPR031831  cGMP-dependent protein kinase, N-terminal coiled-coil domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016358 dendrite development IEA
 biological_processGO:0019934 cGMP-mediated signaling IEA
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0045986 negative regulation of smooth muscle contraction IEA
 biological_processGO:0060087 relaxation of vascular smooth muscle IEA
 biological_processGO:0090331 negative regulation of platelet aggregation IEA
 biological_processGO:1904706 negative regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:1904753 negative regulation of vascular associated smooth muscle cell migration IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004692 cGMP-dependent protein kinase activity IEA
 molecular_functionGO:0005246 calcium channel regulator activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030553 cGMP binding IEA


Pathways (from Reactome)
Pathway description
Rap1 signalling
cGMP effects


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008294 ITPR1 / inositol 1,4,5-trisphosphate receptor type 1 / P11881* / Q14643*  / reaction
 ENSGALG00000033885 RAP1GAP2 / rap1 GTPase-activating protein 2 / Q5SVL6* / Q684P5*  / reaction






 

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