ENSMUSG00000052920


Mus musculus

Features
Gene ID: ENSMUSG00000052920
  
Biological name :Prkg1
  
Synonyms : P0C605 / Prkg1 / protein kinase, cGMP-dependent, type I
  
Possible biological names infered from orthology : Q13976
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C1
Gene start: 30567551
Gene end: 31765033
  
Corresponding Affymetrix probe sets: 10467013 (MoGene1.0st)   1444232_at (Mouse Genome 430 2.0 Array)   1449876_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000067576
Ensembl peptide - ENSMUSP00000073268
Ensembl peptide - ENSMUSP00000138208
NCBI entrez gene - 19091     See in Manteia.
MGI - MGI:108174
RefSeq - XM_006526768
RefSeq - NM_001013833
RefSeq - NM_011160
RefSeq Peptide - NP_035290
RefSeq Peptide - NP_001013855
swissprot - P0C605
swissprot - Q8BND1
swissprot - Q8BQ38
Ensembl - ENSMUSG00000052920
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkg1bENSDARG00000031702Danio rerio
 PRKG1ENSGALG00000003805Gallus gallus
 PRKG1ENSG00000185532Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prkg2 / protein kinase, cGMP-dependent, type II / Q13237*ENSMUSG0000002933452
P68181 / Prkacb / protein kinase, cAMP dependent, catalytic, beta / P22694* / protein kinase cAMP-activated catalytic subunit beta*ENSMUSG0000000503423
P05132 / Prkaca / protein kinase, cAMP dependent, catalytic, alpha / P17612* / protein kinase cAMP-activated catalytic subunit alpha*ENSMUSG0000000546922
Prkx / Q922R0 / cAMP-dependent protein kinase catalytic subunit PRKX / P51817* / protein kinase, X-linked*ENSMUSG0000003572522


Protein motifs (from Interpro)
Interpro ID Name
 IPR000595  Cyclic nucleotide-binding domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002374  cGMP-dependent kinase
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014710  RmlC-like jelly roll fold
 IPR017441  Protein kinase, ATP binding site
 IPR018488  Cyclic nucleotide-binding, conserved site
 IPR018490  Cyclic nucleotide-binding-like
 IPR031831  cGMP-dependent protein kinase, N-terminal coiled-coil domain
 IPR035014  cGMP-dependent protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0007165 signal transduction IDA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016358 dendrite development IMP
 biological_processGO:0019934 cGMP-mediated signaling IMP
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0045986 negative regulation of smooth muscle contraction IMP
 biological_processGO:0060087 relaxation of vascular smooth muscle IMP
 biological_processGO:0090331 negative regulation of platelet aggregation IEA
 biological_processGO:1904706 negative regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:1904753 negative regulation of vascular associated smooth muscle cell migration IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IDA
 molecular_functionGO:0004692 cGMP-dependent protein kinase activity ISO
 molecular_functionGO:0005246 calcium channel regulator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030553 cGMP binding IEA
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
Rap1 signalling
cGMP effects


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prkg1tm2.1Naw/Prkg1tm2.1Naw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0000249 abnormal blood vessel physiology "anomalous function of any of the tubes that convey blood: arteries, arterioles, capallaries, venules, veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Numbtm1Ynj/Numbtm1Ynj
Genetic Background: involves: 129X1/SvJ

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prkg1tm2.1Naw/Prkg1tm2.1Naw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000740 impaired smooth muscle contractility "inability or reduced ability of the smooth muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0001379 abnormal penile erection function "altered ability to achieve a rigid and elevated state of the penis when the erectile tissue becomes filled with blood " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Prkg1tm2.1Naw/Prkg1tm2.1Naw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Wdr35yeti/Wdr35yeti
Genetic Background: Not Specified

 MP:0001898 abnormal long term depression "change from the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Abcc6rs32756904-T/Abcc6rs32756904-T,Dyscalc2C3H/HeJ/?
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Prkg1tm2.1Naw/Prkg1tm2.1Naw,Taglntm1(PRKG1*)Hfm/Tagln+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Prkg1tm2.1Naw/Prkg1tm2.1Naw,Taglntm2(PRKG1*)Hfm/Tagln+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkg1tm2.1Naw/Prkg1tm2.1Naw,Taglntm1(PRKG1*)Hfm/Tagln+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Prkg1tm2.1Naw/Prkg1tm2.1Naw,Taglntm2(PRKG1*)Hfm/Tagln+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fn1tm2Feb/Fn1tm2Feb
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Prkg1tm2.1Naw/Prkg1tm2.1Naw,Taglntm1(PRKG1*)Hfm/Tagln+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Prkg1tm2.1Naw/Prkg1tm2.1Naw,Taglntm2(PRKG1*)Hfm/Tagln+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Prkg1tm2.1Naw/Prkg1tm2.1Naw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc45a2uw/Slc45a2uw
Genetic Background: C57BL/6J-Slc45a2uw/J

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prkg1tm2.1Naw/Prkg1tm2.1Naw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkg1tm2.1Naw/Prkg1tm2.1Naw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkg1tm2.1Naw/Prkg1tm2.1Naw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Numbtm1Ynj/Numbtm1Ynj
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Prkg1tm1.1Arte/Prkg1tm1.1Arte
Genetic Background: C57BL/6-Prkg1tm1.1Arte

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkg1tm2.1Naw/Prkg1tm2.1Naw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002972 abnormal cardiac muscle contractility "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fn1tm2Feb/Fn1tm2Feb
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0003157 impaired muscle relaxation "reduced or absent ability of muscle to lengthen following contractions" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92510]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0003289 abnormal intestinal peristalsis "altered intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Kittm1(cre/ERT2)Dsa/Kit+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0003307 pyloric stenosis "a narrowing of the gastric outlet of the stomach, often due to muscular hypertrophy or scarring from local inflammation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0003393 decreased cardiac output "reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkg1tm1.1Arte/Prkg1tm1.1Arte
Genetic Background: C57BL/6-Prkg1tm1.1Arte

 MP:0004084 abnormal cardiac muscle relaxation "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0004216 salt-resistant hypertension "sustained high blood pressure that is maintained regardless of the amount of salt consumed in the diet" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Numbtm1Ynj/Numbtm1Ynj
Genetic Background: involves: 129X1/SvJ

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Prkg1tm1Meme/Prkg1tm1Meme
Genetic Background: involves: 129S/SvEv

Allelic Composition: Prkg1tm2.1Naw/Prkg1tm2.1Naw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Prkg1tm1.1Arte/Prkg1tm1.1Arte
Genetic Background: C57BL/6-Prkg1tm1.1Arte

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Wdr35yeti/Wdr35yeti
Genetic Background: Not Specified

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prkg1tm2.1Naw/Prkg1tm2.1Naw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkg1tm2.1Naw/Prkg1tm2.1Naw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005591 decreased vasodilation "less than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Numbtm1Ynj/Numbtm1Ynj
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Prkg1tm1.1Arte/Prkg1tm1.1Arte
Genetic Background: C57BL/6-Prkg1tm1.1Arte

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Prkg1tm2.1Naw/Prkg1tm2.1Naw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006001 abnormal intestinal transit time "increase or decrease in the time it takes for a bolus of material to pass through the intestine" [smb:Susan M Bello, Mouse Genome Iformatics Curator]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Prkg1tm2.1Naw/Prkg1tm2.1Naw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Kittm1(cre/ERT2)Dsa/Kit+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0006143 increased diastolic blood pressure "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Numbtm1Ynj/Numbtm1Ynj
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Prkg1tm1.1Arte/Prkg1tm1.1Arte
Genetic Background: C57BL/6-Prkg1tm1.1Arte

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Numbtm1Ynj/Numbtm1Ynj
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Prkg1tm1.1Arte/Prkg1tm1.1Arte
Genetic Background: C57BL/6-Prkg1tm1.1Arte

 MP:0009125 decreased brown fat cell lipid droplet size "reduction in the size of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wdr35yeti/Wdr35yeti
Genetic Background: Not Specified

 MP:0010035 increased erythrocyte clearance "increased elimination of aging erythrocytes from the body by autoregulatory mechanisms, often expressed as half-life" [GO:0034102, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkg1tm2.1Naw/Prkg1tm2.1Naw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010067 increased red blood cell distribution width "higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]
Show

Allelic Composition: Prkg1tm2.1Naw/Prkg1tm2.1Naw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010781 pyloric sphincter hypertrophy "increase in the bulk size of the thick circular layer of gastric musculature encircling the gastroduodenal junction at the gastric outlet of the stomach, due to cell enlargement or accumulation of fluids" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0010786 stomach fundus hypertrophy "increase in the bulk size of the stomach fundus due to cell enlargement or accumulation of fluids" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0011015 decreased body surface temperature "reduced degree of heat natural to skin-environment interface of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wdr35yeti/Wdr35yeti
Genetic Background: Not Specified

 MP:0011082 abnormal gastrointestinal motility "anomaly in the propulsive movements of the digestive system, resulting in the transit of the contents along the gastrointestinal tract" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kittm1(cre/ERT2)Dsa/Kit+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Hsp90aa1Tg(Tyr)2396BOve/Hsp90aa1Tg(Tyr)2396BOve
Genetic Background: FVB/N-Hsp90aa1Tg(Tyr)2396BOve

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ppp3r2tm1.1(KOMP)Vlcg/Ppp3r2tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ppp3r2tm1.1(KOMP)Vlcg/Ucd

 MP:0011167 abnormal adipose tissue development "anomaly in the process of the formation of the connective tissue composed of fat cells enmeshed in areolar tissue" [MESH:A10.165.114, MGI:csmith]
Show

Allelic Composition: Wdr35yeti/Wdr35yeti
Genetic Background: Not Specified

Allelic Composition: Prkg1tm1Hfm/Prkg1tm1Hfm
Genetic Background: involves: C57BL/6N

 MP:0011639 decreased mitochondrial DNA content "less than expected amount of DNA contained within the mirochondria of a eukaryotic cell" [MGI:csmith]
Show

Allelic Composition: Prkg1tm1Hfm/Prkg1tm1Hfm
Genetic Background: involves: C57BL/6N

 MP:0011699 abnormal brown adipose tissue thermogenesis "any anomaly in the process of heat production in brown adipocytes" [MGI:smb]
Show

Allelic Composition: Prkg1tm1Hfm/Prkg1tm1Hfm
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005611 Mrvi1 / Q9WUX5 / Protein MRVI1 / Q9Y6F6* / murine retrovirus integration site 1 homolog*  / reaction
 ENSMUSG00000030102 Itpr1 / P11881 / Inositol 1,4,5-trisphosphate receptor type 1 / Q14643*  / reaction
 ENSMUSG00000038807 Q5SVL6 / Rap1gap2 / Rap1 GTPase-activating protein 2 / Q684P5*  / reaction
 ENSMUSG00000052920 Prkg1 / P0C605 / protein kinase, cGMP-dependent, type I / Q13976*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr