ENSGALG00000006087


Gallus gallus

Features
Gene ID: ENSGALG00000006087
  
Biological name :GPC3
  
Synonyms : glypican 3 / GPC3
  
Possible biological names infered from orthology : P51654 / Q8CFZ4
  
Species: Gallus gallus
  
Chr. number: 4
Strand: -1
Band:
Gene start: 3865352
Gene end: 3986168
  
Corresponding Affymetrix probe sets: GgaAffx.3795.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000009806
Ensembl peptide - ENSGALP00000043631
NCBI entrez gene - 770863     See in Manteia.
RefSeq - XM_015278659
swissprot - A0A1D5NTH6
swissprot - F1N8X1
Ensembl - ENSGALG00000006087
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpc3ENSDARG00000032199Danio rerio
 GPC3ENSG00000147257Homo sapiens
 Gpc3ENSMUSG00000055653Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GPC5 / glypican 5 / P78333* / Q8CAL5*ENSGALG0000001690235
ENSGALG0000000672430
GPC4 / glypican 4 / O75487* / P51655*ENSGALG0000000608022
GPC6 / glypican 6 / Q9R087* / Q9Y625*ENSGALG0000001690019
GPC1 / glypican 1 / P35052* / Q9QZF2*ENSGALG0000004031618


Protein motifs (from Interpro)
Interpro ID Name
 IPR001863  Glypican
 IPR015501  Glypican-3
 IPR019803  Glypican, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0009948 anterior/posterior axis specification IEA
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0010171 body morphogenesis IEA
 biological_processGO:0030282 bone mineralization IEA
 biological_processGO:0030316 osteoclast differentiation IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030513 positive regulation of BMP signaling pathway IEA
 biological_processGO:0035116 embryonic hindlimb morphogenesis IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0045807 positive regulation of endocytosis IEA
 biological_processGO:0045879 negative regulation of smoothened signaling pathway IEA
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IEA
 biological_processGO:0045926 negative regulation of growth IEA
 biological_processGO:0046326 positive regulation of glucose import IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0060976 coronary vasculature development IEA
 biological_processGO:0072111 cell proliferation involved in kidney development IEA
 biological_processGO:0072138 mesenchymal cell proliferation involved in ureteric bud development IEA
 biological_processGO:0072180 mesonephric duct morphogenesis IEA
 biological_processGO:0072203 cell proliferation involved in metanephros development IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0046658 anchored component of plasma membrane IEA
 molecular_functionGO:0043395 heparan sulfate proteoglycan binding IEA
 molecular_functionGO:0060422 peptidyl-dipeptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
A tetrasaccharide linker sequence is required for GAG synthesis
HS-GAG biosynthesis
HS-GAG degradation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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