ENSGALG00000007562


Gallus gallus

Features
Gene ID: ENSGALG00000007562
  
Biological name :FGF4
  
Synonyms : FGF4 / fibroblast growth factor 4 precursor
  
Possible biological names infered from orthology : fibroblast growth factor 4 / P08620 / P11403
  
Species: Gallus gallus
  
Chr. number: 5
Strand: -1
Band:
Gene start: 17590651
Gene end: 17593587
  
Corresponding Affymetrix probe sets: GgaAffx.4716.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000012214
NCBI entrez gene - 428857     See in Manteia.
RefSeq - NM_001031546
RefSeq Peptide - NP_001026717
swissprot - E1BZW7
Ensembl - ENSGALG00000007562
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgf4ENSDARG00000105230Danio rerio
 FGF4ENSG00000075388Homo sapiens
 Fgf4ENSMUSG00000050917Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FGF6 / fibroblast growth factor 6 / P10767* / P21658*ENSGALG0000001728760
FGF20 / fibroblast growth factor 20 / Q9ESL9* / Q9NP95*ENSGALG0000001366335
FGF3 / P48801 / Fibroblast growth factor 3 / P11487*ENSGALG0000002685332
FGF13 / fibroblast growth factor 13 / P70377* / Q92913* / Mus musculus fibroblast growth factor 13 (Fgf13), transcript variant 4, mRNA.*ENSGALG0000000650831
FGF10 / fibroblast growth factor 10 / O15520* / O35565*ENSGALG0000001487231
FGF16 / fibroblast growth factor 16 / O43320* / Q9ESL8*ENSGALG0000000780630
FGF9 / fibroblast growth factor 9 / P31371* / P54130*ENSGALG0000002574830
FGF12 / fibroblast growth factor 12 / P61328* / P61329*ENSGALG0000003697130
FGF14 / fibroblast growth factor 14 / Q92915*ENSGALG0000001686627
FGF7 / fibroblast growth factor 7 / P21781* / P36363*ENSGALG0000002815827
FGF22 / fibroblast growth factor 22 / Q9ESS2* / Q9HCT0*ENSGALG0000004182227
FGF5 / fibroblast growth factor 5 / P12034* / P15656*ENSGALG0000004552122


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028239  Fibroblast growth factor 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001502 cartilage condensation IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0010463 mesenchymal cell proliferation IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0019827 stem cell population maintenance IEA
 biological_processGO:0030326 embryonic limb morphogenesis IEA
 biological_processGO:0035116 embryonic hindlimb morphogenesis IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0060363 cranial suture morphogenesis IEA
 biological_processGO:0060561 apoptotic process involved in morphogenesis IEA
 biological_processGO:0060591 chondroblast differentiation IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 biological_processGO:2000544 regulation of endothelial cell chemotaxis to fibroblast growth factor IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
FGFR4 ligand binding and activation
FGFR3c ligand binding and activation
FGFR1c ligand binding and activation
FGFR2c ligand binding and activation
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
FGFRL1 modulation of FGFR1 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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