ENSGALG00000008357


Gallus gallus
ionTPCN1transportmembranechannelcalciumtransmembraneactivitydomainvoltage-dependentsuperfamilyregulationautophagyreleasesequesteredcytosoldepolarizationactionpotentiallysosomalplasmaendosomeintegralcomponentvoltage-gatedidenticalproteinbindingnaadp-sensitivecalcium-releasestimuli-sensing

Features
Gene ID: ENSGALG00000008357
  
Biological name :TPCN1
  
Synonyms : TPCN1 / two pore segment channel 1
  
Possible biological names infered from orthology : Q9EQJ0 / Q9ULQ1 / Two pore calcium channel protein 1
  
Species: Gallus gallus
  
Chr. number: 15
Strand: -1
Band:
Gene start: 12661721
Gene end: 12714319
  
Corresponding Affymetrix probe sets: GgaAffx.22548.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000013593
Ensembl peptide - ENSGALP00000054636
NCBI entrez gene - 417033     See in Manteia.
RefSeq - XM_415322
RefSeq - XM_004934492
RefSeq - XM_015294861
RefSeq - XM_004934490
RefSeq - XM_004934491
swissprot - E1BQ97
swissprot - A0A1D5PP39
Ensembl - ENSGALG00000008357
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tpcn1ENSDARG00000062362Danio rerio
 TPCN1ENSG00000186815Homo sapiens
 Tpcn1ENSMUSG00000032741Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TPCN3 / two-pore calcium channel 3 ENSGALG0000000819821
TPCN2 / two pore segment channel 2 / Q8BWC0* / Q8NHX9* / Two pore calcium channel protein 2 *ENSGALG0000000755019


Protein motifs (from Interpro)
Interpro ID Name
 IPR005821  Ion transport domain
 IPR027359  Voltage-dependent channel domain superfamily


Gene Ontology (GO)
establishment of localizationcatabolic processcellular metabolic processprocess utilizing autophagic mechanismregulation of biological qualitycellular localizationestablishment of localizationcatabolic processcellular metabolic processprocess utilizing autophagic mechanismregulation of biological qualitycellular localizationestablishment of localizationcatabolic processcellular metabolic processprocess utilizing autophagic mechanismregulation of biological qualitycellular localizationestablishment of localizationcatabolic processcellular metabolic processprocess utilizing autophagic mechanismregulation of biological qualitycellular localizationestablishment of localizationcatabolic processcellular metabolic processprocess utilizing autophagic mechanismregulation of biological qualitycellular localizationestablishment of localizationcatabolic processcellular metabolic processprocess utilizing autophagic mechanismregulation of biological qualitycellular localizationestablishment of localizationcatabolic processcellular metabolic processprocess utilizing autophagic mechanismregulation of biological qualitycellular localizationestablishment of localizationcatabolic processcellular metabolic processprocess utilizing autophagic mechanismregulation of biological qualitycellular localizationestablishment of localizationcatabolic processcellular metabolic processprocess utilizing autophagic mechanismregulation of biological qualitycellular localizationestablishment of localizationcatabolic processcellular metabolic processprocess utilizing autophagic mechanismregulation of biological qualitycellular localizationestablishment of localiestablishment of localizationcatabolic processcatabolic processcellular metabolic proccellular metabolic processprocess utilizing autopprocess utilizing autophagic mechanismregulation of biologicaregulation of biological qualitycellular localizationcellular localization
transmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activityprotein bindingtransmembrane transporter activitytransmembrane transporter activityprotein bindingprotein binding
cellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellcellmembranemembraneorganelleorganelle
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IBA
 biological_processGO:0010508 positive regulation of autophagy IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0086010 membrane depolarization during action potential IBA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0072345 NAADP-sensitive calcium-release channel activity IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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