ENSMUSG00000032741


Mus musculus

Features
Gene ID: ENSMUSG00000032741
  
Biological name :Tpcn1
  
Synonyms : Q9EQJ0 / Tpcn1 / Two pore calcium channel protein 1
  
Possible biological names infered from orthology : Q9ULQ1 / two pore segment channel 1
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 120534153
Gene end: 120588673
  
Corresponding Affymetrix probe sets: 10533145 (MoGene1.0st)   1434930_at (Mouse Genome 430 2.0 Array)   1451771_at (Mouse Genome 430 2.0 Array)   1451772_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000042188
NCBI entrez gene - 252972     See in Manteia.
MGI - MGI:2182472
RefSeq - NM_145853
RefSeq - XM_011248201
RefSeq Peptide - NP_665852
swissprot - Q9EQJ0
Ensembl - ENSMUSG00000032741
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tpcn1ENSDARG00000062362Danio rerio
 TPCN1ENSGALG00000008357Gallus gallus
 TPCN1ENSG00000186815Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tpcn2 / Q8BWC0 / Two pore calcium channel protein 2 / Q8NHX9* / two pore segment channel 2*ENSMUSG0000004867719


Protein motifs (from Interpro)
Interpro ID Name
 IPR005821  Ion transport domain
 IPR028801  Two pore calcium channel protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IBA
 biological_processGO:0010508 positive regulation of autophagy IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0086010 membrane depolarization during action potential IBA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane ISO
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0010008 endosome membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0072345 NAADP-sensitive calcium-release channel activity IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pak2tm1Dgen/Pak2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Tpcn1Gt(OST359423)Lex/Tpcn1Gt(OST359423)Lex
Genetic Background: B6;129S5-Tpcn1Gt(OST359423)Lex/Orl

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mex3cGt(DD0642)Wtsi/Mex3cGt(DD0642)Wtsi
Genetic Background: FVB.129P2(B6)-Mex3cGt(DD0642)Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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