ENSMUSG00000048677


Mus musculus

Features
Gene ID: ENSMUSG00000048677
  
Biological name :Tpcn2
  
Synonyms : Q8BWC0 / Tpcn2 / Two pore calcium channel protein 2
  
Possible biological names infered from orthology : Q8NHX9 / two pore segment channel 2
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F5
Gene start: 145186524
Gene end: 145284011
  
Corresponding Affymetrix probe sets: 10569656 (MoGene1.0st)   1424304_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000061308
Ensembl peptide - ENSMUSP00000147224
Ensembl peptide - ENSMUSP00000147178
Ensembl peptide - ENSMUSP00000146952
Ensembl peptide - ENSMUSP00000146736
Ensembl peptide - ENSMUSP00000146538
NCBI entrez gene - 233979     See in Manteia.
MGI - MGI:2385297
RefSeq - XM_017322226
RefSeq - XM_017322225
RefSeq - XM_006508613
RefSeq - XM_006508614
RefSeq - NM_146206
RefSeq - XM_011241998
RefSeq Peptide - NP_666318
swissprot - Q8BWC0
swissprot - A0A140LJI3
swissprot - A0A140LHT5
swissprot - A0A140LIA1
swissprot - A0A140LIT7
swissprot - A0A140LJE2
Ensembl - ENSMUSG00000048677
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tpcn2ENSDARG00000100420Danio rerio
 TPCN2ENSGALG00000007550Gallus gallus
 TPCN2ENSG00000162341Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tpcn1 / Q9EQJ0 / Two pore calcium channel protein 1 / Q9ULQ1* / two pore segment channel 1*ENSMUSG0000003274121


Protein motifs (from Interpro)
Interpro ID Name
 IPR005821  Ion transport domain
 IPR028798  Two pore calcium channel protein 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0006939 smooth muscle contraction IMP
 biological_processGO:0007040 lysosome organization IEA
 biological_processGO:0010506 regulation of autophagy IEA
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0033280 response to vitamin D IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0086010 membrane depolarization during action potential IBA
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0072345 NAADP-sensitive calcium-release channel activity IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tpcn1Gt(OST359423)Lex/Tpcn1Gt(OST359423)Lex
Genetic Background: B6;129S5-Tpcn1Gt(OST359423)Lex/Orl

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mex3cGt(DD0642)Wtsi/Mex3cGt(DD0642)Wtsi
Genetic Background: FVB.129P2(B6)-Mex3cGt(DD0642)Wtsi

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2atm1Cjs/Cdkn2a+,Tgfb2tm1Doe/Tgfb2tm1Doe
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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