ENSGALG00000010346


Gallus gallus

Features
Gene ID: ENSGALG00000010346
  
Biological name :TGFB3
  
Synonyms : TGFB3 / transforming growth factor beta 3
  
Possible biological names infered from orthology : P10600
  
Species: Gallus gallus
  
Chr. number: 5
Strand: -1
Band:
Gene start: 38503286
Gene end: 38517228
  
Corresponding Affymetrix probe sets: Gga.1686.1.S1_s_at (Chicken Array)   GgaAffx.21450.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000036912
NCBI entrez gene - 396438     See in Manteia.
RefSeq - NM_205454
RefSeq Peptide - NP_990785
swissprot - F1NRQ9
Ensembl - ENSGALG00000010346
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tgfb3ENSDARG00000019367Danio rerio
 TGFB3ENSG00000119699Homo sapiens
 Tgfb3ENSMUSG00000021253Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TGFB2 / P27090* / P61812* / transforming growth factor beta 2* / Transforming growth factor beta-2 Latency-associated peptide*ENSGALG0000000961256
GDF8 / O42220 / Growth/differentiation factor 8 / MSTN* / O08689* / O14793* / myostatin*ENSGALG0000003945824
INHBA / inhibin beta A chain precursor / P08476* / Q04998* / Inhibin beta A chain * / inhibin beta A subunit*ENSGALG0000003461621
GDF3 / embryonic growth/differentiation factor 1 / GDF1* / CERS1* / P27545* / P27544* / Q9NR23* / Q07104* / P20863* / P27539* / ceramide synthase 1* / growth differentiation factor 3* / gr...ENSGALG0000000316117
INHBB / inhibin beta B chain precursor / P09529* / Q04999* / Inhibin beta B chain * / inhibin beta B subunit*ENSGALG0000002877017
BMP3 / bone morphogenetic protein 3 precursor / P12645* / Q8BHE5* / Bone morphotic protein 3 * / bone morphogenetic protein 3*ENSGALG0000003505215
GDF10 / growth differentiation factor 10 / P55107* / P97737*ENSGALG0000000598514
BMP15 / bone morphogenetic protein 15 precursor ENSGALG0000000474213
GDF9 / growth differentiation factor 9 / O60383* / Q07105*ENSGALG0000002840713
NODAL* / P43021* / Q96S42* / nodal growth differentiation factor*ENSGALG0000000320911
GDF15* / Q99988* / Q9Z0J7* / growth differentiation factor 15* / Mus musculus growth differentiation factor 15 (Gdf15), transcript variant 2, mRNA.*ENSGALG000000462787


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR015618  Transforming growth factor beta-3
 IPR016319  Transforming growth factor-beta
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007435 salivary gland morphogenesis IEA
 biological_processGO:0008156 negative regulation of DNA replication IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0010936 negative regulation of macrophage cytokine production IEA
 biological_processGO:0030501 positive regulation of bone mineralization IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IEA
 biological_processGO:0043932 ossification involved in bone remodeling IEA
 biological_processGO:0045216 cell-cell junction organization IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0050714 positive regulation of protein secretion IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0060325 face morphogenesis IEA
 biological_processGO:0070483 detection of hypoxia IEA
 biological_processGO:1904706 negative regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:1905075 positive regulation of occluding junction disassembly IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0005114 type II transforming growth factor beta receptor binding IEA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0034713 type I transforming growth factor beta receptor binding IEA
 molecular_functionGO:0034714 type III transforming growth factor beta receptor binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0050431 transforming growth factor beta binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Molecules associated with elastic fibres


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000010448 LTBP1 / latent-transforming growth factor beta-binding protein 1 precursor / Q14766* / Q8CG19* / latent transforming growth factor beta binding protein 1*  / complex / reaction
 ENSGALG00000010346 TGFB3 / transforming growth factor beta 3 / P10600*  / complex






 

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