ENSMUSG00000002384


Mus musculus

Features
Gene ID: ENSMUSG00000002384
  
Biological name :Bmp8b
  
Synonyms : Bmp8b / Bone morphotic protein 8B / P55105
  
Possible biological names infered from orthology : BMP8A / bone morphogenetic protein 8a / bone morphogenetic protein 8b / P34820 / Q7Z5Y6
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.2
Gene start: 123105165
Gene end: 123132099
  
Corresponding Affymetrix probe sets: 10507817 (MoGene1.0st)   1440706_at (Mouse Genome 430 2.0 Array)   1450342_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002457
NCBI entrez gene - 12164     See in Manteia.
MGI - MGI:107335
RefSeq - NM_007559
RefSeq - XM_011240420
RefSeq Peptide - NP_031585
swissprot - P55105
Ensembl - ENSMUSG00000002384
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bmp8aENSDARG00000035677Danio rerio
 ENSGALG00000038984Gallus gallus
 BMP8AENSG00000183682Homo sapiens
 BMP8BENSG00000116985Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bmp8a / P34821 / Bone morphotic protein 8A / BMP8B* / P34820* / Q7Z5Y6* / bone morphogenetic protein 8b* / bone morphogenetic protein 8a*ENSMUSG0000003272684
Bmp5 / P49003 / Bone morphotic protein 5 / P22003* / bone morphogenetic protein 5*ENSMUSG0000003217951
Bmp7 / P23359 / Bone morphotic protein 7 / P18075* / bone morphogenetic protein 7*ENSMUSG0000000899949
Bmp6 / P20722 / Bone morphotic protein 6 / P22004* / bone morphogenetic protein 6*ENSMUSG0000003900449
Bmp2 / P21274 / Bone morphotic protein 2 / P12643* / bone morphogenetic protein 2*ENSMUSG0000002735829
Bmp4 / P21275 / Bone morphotic protein 4 / P12644* / bone morphogenetic protein 4*ENSMUSG0000002183528
Gdf6 / P43028 / Growth/differentiation factor 6 / Q6KF10*ENSMUSG0000005127926
Gdf2 / Q9WV56 / Growth/differentiation factor 2 / Q9UK05*ENSMUSG0000007262526
Bmp10 / Q9R229 / Bone morphotic protein 10 / O95393* / bone morphogenetic protein 10*ENSMUSG0000003004625
Gdf5 / P43027 / Growth/differentiation factor 5 / P43026*ENSMUSG0000003825925
Gdf7 / P43029 / Growth/differentiation factor 7 / Q7Z4P5*ENSMUSG0000003766024


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0002024 diet induced thermogenesis IMP
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007281 germ cell development IMP
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IMP
 biological_processGO:0048598 embryonic morphogenesis IMP
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity TAS
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0070700 BMP receptor binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
Show

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+,Bmp8btm1Blh/Bmp8b+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * Black Swiss

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
Show

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0001919 abnormal reproductive system physiology "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gusbtm3Sly/Gusbtm3Sly
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0002500 granulomatous inflammation "chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Acetm1Unc/Ace+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002685 abnormal proliferation of spermatogonia "reduction in the proliferation of the spermatogonial stem cells either due to reduced mitosis or increased apoptosis" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:62271]
Show

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0003087 absent allantois "missing fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmp8btm1Blh/Bmp8b+
Genetic Background: either: B6.129-Bmp8btm1Blh or (involves: 129 * Black Swiss * C57BL/6)

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: B6.129-Bmp8btm1Blh

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: involves: 129/Sv * Black Swiss

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: B6.129-Bmp8btm1Blh

 MP:0004188 delayed embryo turning "completion of axial rotation occurs later than in controls but is eventually completed" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]
Show

Allelic Composition: Bmp8btm1Blh/Bmp8b+
Genetic Background: either: B6.129-Bmp8btm1Blh or (involves: 129 * Black Swiss * C57BL/6)

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: B6.129-Bmp8btm1Blh

 MP:0004558 delayed allantois development "late onset of development of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0004559 small allantois "reduced size of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: involves: 129/Sv * Black Swiss

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: either: B6.129-Bmp8btm1Blh or (involves: 129 * Black Swiss * C57BL/6)

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: B6.129-Bmp8btm1Blh

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0004934 epididymis epithelium degeneration "pathological deterioration of the layer of secretory cells which lines the epididymis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+,Bmp8btm1Blh/Bmp8b+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * Black Swiss

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+,Bmp8btm1Blh/Bmp8b+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * Black Swiss

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0008391 abnormal primordial germ cell morphology "any structural anomaly of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0008392 decreased primordial germ cell number "reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: involves: 129/Sv * Black Swiss

Allelic Composition: Bmp8btm1Blh/Bmp8b+
Genetic Background: either: B6.129-Bmp8btm1Blh or (involves: 129 * Black Swiss * C57BL/6)

Allelic Composition: Bmp4tm1Blh/Bmp4+,Bmp8btm1Blh/Bmp8b+
Genetic Background: involves: 129/Sv * 129S2/SvPas * Black Swiss

 MP:0008393 absent primordial germ cells "absence of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: involves: 129/Sv * Black Swiss

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: either: B6.129-Bmp8btm1Blh or (involves: 129 * Black Swiss * C57BL/6)

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: B6.129-Bmp8btm1Blh

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: B6.129-Bmp8btm1Blh

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
Show

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: involves: 129/Sv * Black Swiss

 MP:0013600 testis degeneration "a retrogressive impairment of function or destruction of either or both of the male reproductive glands" [MGI:Anna]
Show

Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh
Genetic Background: involves: 129/Sv * Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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