ENSMUSG00000037660


Mus musculus

Features
Gene ID: ENSMUSG00000037660
  
Biological name :Gdf7
  
Synonyms : Gdf7 / Growth/differentiation factor 7 / P43029
  
Possible biological names infered from orthology : Q7Z4P5
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: A1.1
Gene start: 8297918
Gene end: 8301954
  
Corresponding Affymetrix probe sets: 10399357 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000038301
Ensembl peptide - ENSMUSP00000151234
NCBI entrez gene - 238057     See in Manteia.
MGI - MGI:95690
RefSeq - NM_001312876
RefSeq - NM_013527
RefSeq Peptide - NP_001299805
RefSeq Peptide - NP_038555
swissprot - P43029
Ensembl - ENSMUSG00000037660
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gdf7ENSDARG00000042784Danio rerio
 GDF7ENSG00000143869Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gdf6 / P43028 / Growth/differentiation factor 6 / Q6KF10*ENSMUSG0000005127943
Gdf5 / P43027 / Growth/differentiation factor 5 / P43026*ENSMUSG0000003825938
Bmp4 / P21275 / Bone morphotic protein 4 / P12644* / bone morphogenetic protein 4*ENSMUSG0000002183523
Bmp7 / P23359 / Bone morphotic protein 7 / P18075* / bone morphogenetic protein 7*ENSMUSG0000000899922
Bmp8a / P34821 / Bone morphotic protein 8A / BMP8B* / P34820* / Q7Z5Y6* / bone morphogenetic protein 8b* / bone morphogenetic protein 8a*ENSMUSG0000003272622
Bmp8b / P55105 / Bone morphotic protein 8B / BMP8A* / P34820* / Q7Z5Y6* / bone morphogenetic protein 8b* / bone morphogenetic protein 8a*ENSMUSG0000000238421
Bmp2 / P21274 / Bone morphotic protein 2 / P12643* / bone morphogenetic protein 2*ENSMUSG0000002735821
Bmp10 / Q9R229 / Bone morphotic protein 10 / O95393* / bone morphogenetic protein 10*ENSMUSG0000003004621
Bmp6 / P20722 / Bone morphotic protein 6 / P22004* / bone morphogenetic protein 6*ENSMUSG0000003900421
Bmp5 / P49003 / Bone morphotic protein 5 / P22003* / bone morphogenetic protein 5*ENSMUSG0000003217920
Gdf2 / Q9WV56 / Growth/differentiation factor 2 / Q9UK05*ENSMUSG0000007262518


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007411 axon guidance IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0021509 roof plate formation IMP
 biological_processGO:0021527 spinal cord association neuron differentiation IMP
 biological_processGO:0021915 neural tube development IMP
 biological_processGO:0022612 gland morphogenesis IMP
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0030855 epithelial cell differentiation IMP
 biological_processGO:0030901 midbrain development IMP
 biological_processGO:0032924 activin receptor signaling pathway IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0045165 cell fate commitment IDA
 biological_processGO:0045666 positive regulation of neuron differentiation IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048608 reproductive structure development IMP
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IMP
 biological_processGO:0048853 forebrain morphogenesis IMP
 biological_processGO:0060389 pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 biological_processGO:0060571 morphogenesis of an epithelial fold IMP
 biological_processGO:2001051 positive regulation of tendon cell differentiation IDA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Gdf7tm2Tmj/Gdf7+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gdf7tm1Tmj/Gdf7tm1Tmj
Genetic Background: involves: 129/Sv

Allelic Composition: Gdf7tm3(cre)Tmj/Gdf7+,Otx2tm6Asim/Otx2tm6Asim,Tg(CAG-cat,-EGFP)1Rbns/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000820 abnormal choroid plexus morphology "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
Show

Allelic Composition: Gdf7tm2Tmj/Gdf7+,Tg(Hsp70-1-cre)6Arge/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA

Allelic Composition: Gdf7tm3(cre)Tmj/Gdf7+,Otx2tm6Asim/Otx2tm6Asim,Tg(CAG-cat,-EGFP)1Rbns/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
Show

Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gdf7tm1Tmj/Gdf7tm1Tmj
Genetic Background: involves: 129/Sv

 MP:0000829 dilated fourth ventricle "enlarged irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gdf7tm1Tmj/Gdf7tm1Tmj
Genetic Background: involves: 129/Sv

 MP:0000924 absent roof plate "missing thin layer of the embryonic neural tube connecting the dorsal side" [J:41814]
Show

Allelic Composition: Hspg2tm1Ref/Hspg2tm1Ref,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Hspg2tm1Ref/Hspg2tm1Ref,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Gdf7tm2Tmj/Gdf7+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0001157 small seminal gland "reduced size, compared to the norm, of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Celtm1Eaf/Celtm1Eaf
Genetic Background: involves: 129S4/SvJae

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gdf7tm1Tmj/Gdf7tm1Tmj
Genetic Background: involves: 129/Sv

Allelic Composition: Gdf7tm1Kng/Gdf7tm1Kng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Gdf7tm1Kng/Gdf7tm1Kng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002059 abnormal seminal gland morphology "anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Celtm1Eaf/Celtm1Eaf
Genetic Background: involves: 129S4/SvJae

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Celtm1Eaf/Celtm1Eaf
Genetic Background: involves: 129S4/SvJae

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hspg2tm1Ref/Hspg2tm1Ref,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Gdf7tm3(cre)Tmj/Gdf7+,Otx2tm6Asim/Otx2tm6Asim,Tg(CAG-cat,-EGFP)1Rbns/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004100 abnormal spinal cord interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the spinal cord" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxp3tm2Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gdf7tm1Tmj/Gdf7tm1Tmj
Genetic Background: involves: 129/Sv

Allelic Composition: Gdf7tm2Tmj/Gdf7+,Tg(Hsp70-1-cre)6Arge/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA

 MP:0008934 absent choroid plexus "absence of the fringe of the tela choroidea of the brain ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Gdf7tm2Tmj/Gdf7+,Tmem163Tg(ACTB-cre)2Mrt/0
Genetic Background: involves: 129S1/Sv * FVB/N

 MP:0012089 decreased midbrain size "size reduction or truncation of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna, MGI:csmith]
Show

Allelic Composition: Gdf7tm2Tmj/Gdf7+,Tg(Hsp70-1-cre)6Arge/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA

 MP:0012138 decreased forebrain size "size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
Show

Allelic Composition: Gdf7tm2Tmj/Gdf7+,Tg(Hsp70-1-cre)6Arge/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA

 MP:0013318 abnormal branching involved in seminal vesicle morphogenesis " anomaly in the process in which the seminal vesicle is generated and organized in many mammals including mice and humans; in mice, the initial seminal vesicle buds form cane-shaped tubes off of the Wolffian ducts before birth; after birth, the initial tubes develop lateral branches that elongate and often undergo secondary branching morphogenesis; branching morphogenesis is largely complete by 2 weeks of age" [MGI:Anna, PMID:16916376]
Show

Allelic Composition: Gdf7tm1Kng/Gdf7tm1Kng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0013899 abnormal seminal vesicle epithelium morphology "any structural anomaly of the pseudostratified columnar epithelium that lines the seminal vesicles and consists of tall, non-ciliated columnar cells and short, rounded basal cells that rest on the basal lamina; polarized columnar cells show features typical of secretory epithelium, including a well-developed Golgi complex, abundant rough endoplasmic reticulum, numerous mitochondria, and apical secretory vesicles; basal cells are the stem cells from which the columnar cells are derived" [ISBN:0781767903, ISBN:1455703079, MGI:Anna]
Show

Allelic Composition: Gdf7tm1Kng/Gdf7tm1Kng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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