ENSMUSG00000032726


Mus musculus

Features
Gene ID: ENSMUSG00000032726
  
Biological name :Bmp8a
  
Synonyms : Bmp8a / Bone morphotic protein 8A / P34821
  
Possible biological names infered from orthology : BMP8B / bone morphogenetic protein 8a / bone morphogenetic protein 8b / P34820 / Q7Z5Y6
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.2
Gene start: 123312645
Gene end: 123343252
  
Corresponding Affymetrix probe sets: 10516093 (MoGene1.0st)   1449873_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037779
Ensembl peptide - ENSMUSP00000099701
NCBI entrez gene - 12163     See in Manteia.
MGI - MGI:104515
RefSeq - NM_007558
RefSeq - NM_001256019
RefSeq Peptide - NP_001242948
RefSeq Peptide - NP_031584
swissprot - P34821
swissprot - Q80VZ0
Ensembl - ENSMUSG00000032726
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bmp8aENSDARG00000035677Danio rerio
 ENSGALG00000038984Gallus gallus
 BMP8AENSG00000183682Homo sapiens
 BMP8BENSG00000116985Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bmp8b / P55105 / Bone morphotic protein 8B / BMP8A* / P34820* / Q7Z5Y6* / bone morphogenetic protein 8b* / bone morphogenetic protein 8a*ENSMUSG0000000238482
Bmp7 / P23359 / Bone morphotic protein 7 / P18075* / bone morphogenetic protein 7*ENSMUSG0000000899952
Bmp5 / P49003 / Bone morphotic protein 5 / P22003* / bone morphogenetic protein 5*ENSMUSG0000003217952
Bmp6 / P20722 / Bone morphotic protein 6 / P22004* / bone morphogenetic protein 6*ENSMUSG0000003900451
Bmp2 / P21274 / Bone morphotic protein 2 / P12643* / bone morphogenetic protein 2*ENSMUSG0000002735829
Bmp4 / P21275 / Bone morphotic protein 4 / P12644* / bone morphogenetic protein 4*ENSMUSG0000002183528
Gdf6 / P43028 / Growth/differentiation factor 6 / Q6KF10*ENSMUSG0000005127927
Gdf2 / Q9WV56 / Growth/differentiation factor 2 / Q9UK05*ENSMUSG0000007262526
Bmp10 / Q9R229 / Bone morphotic protein 10 / O95393* / bone morphogenetic protein 10*ENSMUSG0000003004625
Gdf7 / P43029 / Growth/differentiation factor 7 / Q7Z4P5*ENSMUSG0000003766025
Gdf5 / P43027 / Growth/differentiation factor 5 / P43026*ENSMUSG0000003825925


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001649 osteoblast differentiation IDA
 biological_processGO:0002024 diet induced thermogenesis ISO
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007281 germ cell development IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0046676 negative regulation of insulin secretion ISO
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity TAS
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0070700 BMP receptor binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Acetm1Unc/Ace+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Acetm1Unc/Ace+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Bmp8atm1Blh/Bmp8a+,Bmp8btm1Blh/Bmp8b+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * Black Swiss

Allelic Composition: Bmp8atm1Blh/Bmp8a+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Bmp7tm1Rob/Bmp7+,Bmp8atm1Blh/Bmp8atm1Blh
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * Black Swiss * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Acetm1Unc/Ace+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Bmp7tm1Rob/Bmp7+,Bmp8atm1Blh/Bmp8atm1Blh
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * Black Swiss * C57BL/6

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acetm1Unc/Ace+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002500 granulomatous inflammation "chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Acetm1Unc/Ace+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Bmp8atm1Blh/Bmp8a+,Bmp8btm1Blh/Bmp8b+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * Black Swiss

Allelic Composition: Bmp7tm1Rob/Bmp7+,Bmp8atm1Blh/Bmp8atm1Blh
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * Black Swiss * C57BL/6

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acetm1Unc/Ace+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Bmp7tm1Rob/Bmp7+,Bmp8atm1Blh/Bmp8atm1Blh
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * Black Swiss * C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp7tm1Rob/Bmp7+,Bmp8atm1Blh/Bmp8atm1Blh
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * Black Swiss

 MP:0004934 epididymis epithelium degeneration "pathological deterioration of the layer of secretory cells which lines the epididymis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acetm1Unc/Ace+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Bmp8atm1Blh/Bmp8a+,Bmp8btm1Blh/Bmp8b+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * Black Swiss

Allelic Composition: Bmp7tm1Rob/Bmp7+,Bmp8atm1Blh/Bmp8atm1Blh
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * Black Swiss * C57BL/6

 MP:0004935 epididymis degeneration "pathological deterioration of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp7tm1Rob/Bmp7+,Bmp8atm1Blh/Bmp8atm1Blh
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * Black Swiss * C57BL/6

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp8atm1Blh/Bmp8a+,Bmp8btm1Blh/Bmp8b+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * Black Swiss

Allelic Composition: Bmp8atm1Blh/Bmp8a+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Bmp7tm1Rob/Bmp7+,Bmp8atm1Blh/Bmp8atm1Blh
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * Black Swiss * C57BL/6

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Acetm1Unc/Ace+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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