| MP:0000259 | abnormal vascular development | "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509] |
Show
Allelic Composition: Gdf2tm1Lex/Gdf2+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
|
| MP:0000266 | abnormal cardiac morphology | "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Gdf2tm1Lex/Gdf2+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
|
| MP:0000267 | abnormal cardiac development | "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370] |
Show
Allelic Composition: Gdf2tm1Lex/Gdf2+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
|
| MP:0000274 | enlarged heart | "increase over normal size of the heart" [J:29971] |
Show
Allelic Composition: Gdf2tm1Lex/Gdf2+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
|
| MP:0000277 | abnormal heart shape | "malformation of the form or the patterning of the heart" [J:18048] |
Show
Allelic Composition: Gdf2tm1Lex/Gdf2+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
|
| MP:0000279 | ventricular hypoplasia | "reduction in cell number of one or both of the two lower chambers of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790] |
Show
Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)
|
| MP:0000280 | thin ventricular wall | "decreased depth of the cardiac wall of the heart ventricles" [J:45302] |
Show
Allelic Composition: Gdf2tm1Lex/Gdf2+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
|
| MP:0000284 | double outlet right ventricle | "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826] |
Show
Allelic Composition: Ccdc88atm1Mat/Ccdc88a+
Genetic Background: Not Specified
|
| MP:0000291 | enlarged pericardium | "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971] |
Show
Allelic Composition: Gdf2tm1Lex/Gdf2+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
|
| MP:0000295 | poorly developed ventricular trabeculae | "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971] |
Show
Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)
|
| MP:0000298 | absent endocardial cushion | "absence of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [MGI:CLS] |
Show
Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)
|
| MP:0001698 | reduced embryo size | "smaller proportions of embryo compared to littermates" [J:61790] |
Show
Allelic Composition: Gdf2tm1Lex/Gdf2+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
|
| MP:0001719 | absent vitelline blood vessels | "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623] |
Show
Allelic Composition: Gdf2tm1Lex/Gdf2+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
|
| MP:0001730 | embryonic growth arrest | "the cessation of development beyond a particular stage" [J:17509] |
Show
Allelic Composition: Gdf2tm1Lex/Gdf2+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
|
| MP:0001787 | pericardial edema | "accumulation of watery fluid in the pericardial sac of the heart" [J:52597] |
Show
Allelic Composition: Gdf2tm1Lex/Gdf2+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
|
| MP:0001823 | thymus hypoplasia | "small size due to reduced cell number in the thymus" [J:23255] |
Show
Allelic Composition: Ccdc88atm1Mat/Ccdc88a+
Genetic Background: Not Specified
|
| MP:0001914 | hemorrhage | "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Gdf2tm1Lex/Gdf2+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
|
| MP:0002192 | hydrops fetalis | "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gdf2tm1Lex/Gdf2+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
|
| MP:0002740 | heart hypoplasia | "decreased cell number in the heart" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:77765] |
Show
Allelic Composition: Gdf2tm1Lex/Gdf2+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
|
| MP:0002833 | increased heart weight | "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission] |
Show
Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg
|
| MP:0003051 | curly tail | "a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ccdc88atm1Mat/Ccdc88a+
Genetic Background: Not Specified
|
| MP:0004068 | dilated dorsal aorta | "an expansion in the volume of the dorsal region of the main trunk of the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gdf2tm1Lex/Gdf2+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
|
| MP:0004076 | abnormal vitelline vascular remodelling | "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gdf2tm1Lex/Gdf2+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
|
| MP:0004783 | abnormal cardinal vein morphology | "any structural anomaly of any of the four veins in the developing vertebrate embryo which run along each side of the vertebral column" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gdf2tm1Lex/Gdf2+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
|
| MP:0005292 | improved glucose tolerance | "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg
|
| MP:0005333 | decreased heart rate | "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764] |
Show
Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)
|
| MP:0005554 | decreased circulating creatinine level | "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
Show
Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg
|
| MP:0006093 | arteriovenous malformation | "fusion of an artery and vein without an intervening capillary bed" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93125] |
Show
Allelic Composition: Gdf2tm1Lex/Gdf2+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
|
| MP:0008528 | polycystic kidney | "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ccdc88atm1Mat/Ccdc88a+
Genetic Background: Not Specified
|
| MP:0008816 | petechiae | "very small blood spots or splotches that appear especially in skin as a result of localized hemorrhage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ccdc88atm1Mat/Ccdc88a+
Genetic Background: Not Specified
|
| MP:0010402 | ventricular septal defect | "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540] |
Show
Allelic Composition: Gdf2tm1Lex/Gdf2+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
|
| MP:0010417 | subarterial ventricular septal defect | "abnormal communications between the two lower chambers of the heart, located beneath the pulmonic valve, communicating with the RV outflow tract above the supraventricular crest, and are associated with aortic regurgitation secondary to the prolapse of the right aortic cusp" [http://emedicine.medscape.com] |
Show
Allelic Composition: Ccdc88atm1Mat/Ccdc88a+
Genetic Background: Not Specified
|
| MP:0010460 | pulmonary artery hypoplasia | "underdevelopment or reduced size of the artery that arises from the right ventricle and conveys unaerated blood to the lungs, usually due to reduced cell number" [MESH:A07.231.114.715] |
Show
Allelic Composition: Ccdc88atm1Mat/Ccdc88a+
Genetic Background: Not Specified
|
| MP:0010586 | absent conotruncal ridges | "absence of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8823298] |
Show
Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)
|
| MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
Show
Allelic Composition: Hand1tm1Cse/Hand1tm1Cse
Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * Swiss Webster)
|
| MP:0011099 | complete lethality throughout fetal growth and development | "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
Show
Allelic Composition: Gdf2tm1Lex/Gdf2+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
|
| MP:0011100 | complete preweaning lethality | "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith] |
Show
Allelic Composition: Bex2tm1b(EUCOMM)Hmgu/Bex2tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Bex2tm1b(EUCOMM)Hmgu/Ieg
|
| MP:0011395 | decreased fetal cardiomyocyte proliferation | "reduced ability of the differentiating cardiac muscle cell population to undergo expansion by cell division" [MGI:csmith] |
Show
Allelic Composition: Gdf2tm1Lex/Gdf2+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
|
