ENSGALG00000000120


Gallus gallus

Features
Gene ID: ENSGALG00000000120
  
Biological name :BMP10
  
Synonyms : BMP10 / bone morphogenetic protein 10
  
Possible biological names infered from orthology : Bone morphotic protein 10 / O95393 / Q9R229
  
Species: Gallus gallus
  
Chr. number: 22
Strand: 1
Band:
Gene start: 284593
Gene end: 290447
  
Corresponding Affymetrix probe sets: Gga.9509.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000000168
NCBI entrez gene - 395177     See in Manteia.
RefSeq - NM_001278046
RefSeq Peptide - NP_001264975
swissprot - F6S3W4
Ensembl - ENSGALG00000000120
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bmp10ENSDARG00000061769Danio rerio
 bmp10lENSDARG00000109233Danio rerio
 BMP10ENSG00000163217Homo sapiens
 Bmp10ENSMUSG00000030046Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GDF2 / P34822 / Dorsalin-1 / Q9WV56* / Q9UK05* / growth differentiation factor 2*ENSGALG0000000598144
BMP2 / bone morphogenetic protein 2 precursor / P12643* / P21274* / Bone morphotic protein 2 * / bone morphogenetic protein 2*ENSGALG0000002930129
BMP4 / bone morphogenetic protein 4 / P12644* / P21275* / Bone morphotic protein 4 *ENSGALG0000001242928
BMP7 / bone morphogenetic protein 7 / P18075* / P23359* / Bone morphotic protein 7 *ENSGALG0000000766827
GDF5 / growth/differentiation factor 5 precursor / P43026* / P43027* / growth differentiation factor 5*ENSGALG0000003835526
BMP5 / bone morphogenetic protein 5 / P22003* / P49003* / Bone morphotic protein 5 *ENSGALG0000001629325
BMP8B* / BMP8A* / Q7Z5Y6* / P34820* / P34821* / P55105* / Bone morphotic protein 8A * / Bone morphotic protein 8B * / bone morphogenetic protein 8a* / bone morphogenetic protein 8b*ENSGALG0000003898425
GDF6 / growth differentiation factor 6 / P43028* / Q6KF10*ENSGALG0000003590124
ADMP / anti-dorsalizing morphogenetic protein precursor ENSGALG0000003740824
ENSGALG0000000623921
BMP6 / bone morphogenetic protein 6 / P20722* / P22004* / Bone morphotic protein 6 *ENSGALG0000001278720


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007512 adult heart development IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010596 negative regulation of endothelial cell migration IEA
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy IEA
 biological_processGO:0010614 negative regulation of cardiac muscle hypertrophy IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0032924 activin receptor signaling pathway IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048468 cell development IBA
 biological_processGO:0055009 atrial cardiac muscle tissue morphogenesis IEA
 biological_processGO:0055010 ventricular cardiac muscle tissue morphogenesis IEA
 biological_processGO:0055015 ventricular cardiac muscle cell development IEA
 biological_processGO:0055117 regulation of cardiac muscle contraction IEA
 biological_processGO:0060038 cardiac muscle cell proliferation IEA
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0060298 positive regulation of sarcomere organization IEA
 biological_processGO:0060347 heart trabecula formation IEA
 biological_processGO:0060389 pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 biological_processGO:0061036 positive regulation of cartilage development IEA
 biological_processGO:1903242 regulation of cardiac muscle hypertrophy in response to stress IEA
 biological_processGO:2000138 positive regulation of cell proliferation involved in heart morphogenesis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0030018 Z disc IEA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0031433 telethonin binding IEA
 molecular_functionGO:0033612 receptor serine/threonine kinase binding IEA


Pathways (from Reactome)
Pathway description
Signaling by BMP
Molecules associated with elastic fibres


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000120 BMP10 / bone morphogenetic protein 10 / O95393* / Q9R229* / Bone morphotic protein 10 *  / complex
 ENSGALG00000035635 ACVRL1 / activin A receptor like type 1 / P37023* / Q61288* / Serine/threonine-protein kinase receptor R3 *  / complex / reaction






 

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