ENSMUSG00000008438


Mus musculus
domainAdam21activitypeptidasedisintegrinegf-likembadamreprolysinconservedsitemetallopeptidasesuperfamilymembranepropeptidecysteine-richcatalyticadamalysin-typeproteolysisintegralcomponentaxonneuronprojectionneuronalcellbodymetalloendopeptidasehydrolasemetal

Features
Gene ID: ENSMUSG00000008438
  
Biological name :Adam21
  
Synonyms : Adam21 / Disintegrin and metalloproteinase domain-containing protein 21 / Q9JI76
  
Possible biological names infered from orthology : ADAM metallopeptidase domain 21 / Q9UKJ8
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: D1
Gene start: 81558584
Gene end: 81568474
  
Corresponding Affymetrix probe sets: 10401330 (MoGene1.0st)   1450801_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000008582
NCBI entrez gene - 56622     See in Manteia.
MGI - MGI:1861229
RefSeq - NM_020330
RefSeq Peptide - NP_065063
swissprot - Q9JI76
Ensembl - ENSMUSG00000008438
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:174164ENSDARG00000057138Danio rerio
 ENSGALG00000013838Gallus gallus
 ADAM21ENSG00000139985Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adam20 / a disintegrin and metallopeptidase domain 20ENSMUSG0000004628243
Adam39 / a disintegrin and metallopeptidase domain 39ENSMUSG0000005403343
Adam25ENSMUSG0000007193742
Adam29 / ADAM metallopeptidase domain 29 / Q9UKF5*ENSMUSG0000004625841
Adam24 / Q9R160 / Disintegrin and metalloproteinase domain-containing protein 24 ENSMUSG0000004672340
Gm5346ENSMUSG0000005019040
Adam26b / a disintegrin and metallopeptidase domain 26BENSMUSG0000006390040
Adam34 / a disintegrin and metallopeptidase domain 34ENSMUSG0000007905840
Q9R158 / Adam26a / Disintegrin and metalloproteinase domain-containing protein 26A ENSMUSG0000004851639
Adam9 / Q61072 / Disintegrin and metalloproteinase domain-containing protein 9 / Q13443* / ADAM metallopeptidase domain 9*ENSMUSG0000003155535
Adam1a / O54992 / Q60813 / Disintegrin and metalloproteinase domain-containing protein 1a ENSMUSG0000007264734
Adam30 / a disintegrin and metallopeptidase domain 30 / Q9UKF2* / ADAM metallopeptidase domain 30*ENSMUSG0000004346833
Adam1b / Q8R534 / Disintegrin and metalloproteinase domain-containing protein 1b ENSMUSG0000006243832
Adam6a / a disintegrin and metallopeptidase domain 6AENSMUSG0000004394531
Adam4 / a disintegrin and metallopeptidase domain 4ENSMUSG0000007297231
Gm4787ENSMUSG0000007297431
Adam6b / a disintegrin and metallopeptidase domain 6BENSMUSG0000005180430
Adam2 / Q60718 / Disintegrin and metalloproteinase domain-containing protein 2 / Q99965* / ADAM metallopeptidase domain 2*ENSMUSG0000002203928
Adam32 / Q8K410 / Disintegrin and metalloproteinase domain-containing protein 32 / Q8TC27* / ADAM metallopeptidase domain 32*ENSMUSG0000003743727
Adam3 / F8VQ03 / A disintegrin and metallopeptidase domain 3 ENSMUSG0000003155326


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR001762  Disintegrin domain
 IPR002870  Peptidase M12B, propeptide
 IPR006586  ADAM, cysteine-rich
 IPR013032  EGF-like, conserved site
 IPR018358  Disintegrin, conserved site
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR034027  Reprolysin domain, adamalysin-type
 IPR036436  Disintegrin domain superfamily


Gene Ontology (GO)
nitrogen compound metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processnitrogen compound metabolic processnitrogen compound metabolic processprimary metabolic processprimary metabolic processorganic substance metabolic processorganic substance metabolic process
catalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteinhydrolase activityion bindingcatalytic activity, acting on a proteincatalytic activity, acting on a proteinhydrolase activityhydrolase activityion bindingion binding
membranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranemembranecellcell
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Interaction With The Zona Pellucida


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fn1tm1Ref/Fn1tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022039 Adam2 / Q60718 / Disintegrin and metalloproteinase domain-containing protein 2 / Q99965* / ADAM metallopeptidase domain 2*  / complex
 ENSMUSG00000043468 Adam30 / a disintegrin and metallopeptidase domain 30 / Q9UKF2* / ADAM metallopeptidase domain 30*  / complex
 ENSMUSG00000028413 P15535 / B4galt1 / Beta-1,4-galactosyltransferase 1 Lactose synthase A protein N-acetyllactosamine synthase Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase Beta-N-acetyl...  / complex / reaction






 

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