ENSMUSG00000022039


Mus musculus

Features
Gene ID: ENSMUSG00000022039
  
Biological name :Adam2
  
Synonyms : Adam2 / Disintegrin and metalloproteinase domain-containing protein 2 / Q60718
  
Possible biological names infered from orthology : ADAM metallopeptidase domain 2 / Q99965
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D1
Gene start: 66027329
Gene end: 66077733
  
Corresponding Affymetrix probe sets: 10420913 (MoGene1.0st)   1460374_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022618
NCBI entrez gene - 11495     See in Manteia.
MGI - MGI:1340894
RefSeq - NM_009618
RefSeq - XM_006518439
RefSeq Peptide - NP_033748
swissprot - Q60718
Ensembl - ENSMUSG00000022039
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:174164ENSDARG00000057138Danio rerio
 ENSGALG00000044866Gallus gallus
 ENSGALG00000044168Gallus gallus
 ADAM2ENSG00000104755Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adam18 / Q9R157 / Disintegrin and metalloproteinase domain-containing protein 18 / Q9Y3Q7* / ADAM metallopeptidase domain 18*ENSMUSG0000003155237
Adam3 / F8VQ03 / A disintegrin and metallopeptidase domain 3 ENSMUSG0000003155336
Adam32 / Q8K410 / Disintegrin and metalloproteinase domain-containing protein 32 / Q8TC27* / ADAM metallopeptidase domain 32*ENSMUSG0000003743736
Adam5 / Q3TTE0 / Disintegrin and metalloproteinase domain-containing protein 5 ENSMUSG0000003155433
Adam9 / Q61072 / Disintegrin and metalloproteinase domain-containing protein 9 / Q13443* / ADAM metallopeptidase domain 9*ENSMUSG0000003155532
Adam1b / Q8R534 / Disintegrin and metalloproteinase domain-containing protein 1b ENSMUSG0000006243830
Adam1a / O54992 / Q60813 / Disintegrin and metalloproteinase domain-containing protein 1a ENSMUSG0000007264729
Adam30 / a disintegrin and metallopeptidase domain 30 / Q9UKF2* / ADAM metallopeptidase domain 30*ENSMUSG0000004346828
Adam24 / Q9R160 / Disintegrin and metalloproteinase domain-containing protein 24 ENSMUSG0000004672328
Gm5346ENSMUSG0000005019028
Adam34 / a disintegrin and metallopeptidase domain 34ENSMUSG0000007905828
Adam21 / Q9JI76 / Disintegrin and metalloproteinase domain-containing protein 21 / Q9UKJ8* / ADAM metallopeptidase domain 21*ENSMUSG0000000843827
Q9R158 / Adam26a / Disintegrin and metalloproteinase domain-containing protein 26A ENSMUSG0000004851627
Adam26b / a disintegrin and metallopeptidase domain 26BENSMUSG0000006390027
Adam29 / ADAM metallopeptidase domain 29 / Q9UKF5*ENSMUSG0000004625826
Adam20 / a disintegrin and metallopeptidase domain 20ENSMUSG0000004628226
Adam39 / a disintegrin and metallopeptidase domain 39ENSMUSG0000005403326
Adam25ENSMUSG0000007193726
Adam4 / a disintegrin and metallopeptidase domain 4ENSMUSG0000007297226
Adam6b / a disintegrin and metallopeptidase domain 6BENSMUSG0000005180425


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR001762  Disintegrin domain
 IPR002870  Peptidase M12B, propeptide
 IPR006586  ADAM, cysteine-rich
 IPR018358  Disintegrin, conserved site
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR033958  ADAM2 protein
 IPR034027  Reprolysin domain, adamalysin-type
 IPR036436  Disintegrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007155 cell adhesion IGI
 biological_processGO:0007338 single fertilization IEA
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0030534 adult behavior IMP
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008237 metallopeptidase activity IEA


Pathways (from Reactome)
Pathway description
Interaction With The Zona Pellucida


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0005410 abnormal fertilization "anomaly in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Adam2tm1Dgm/Adam2tm1Dgm,Adam3tm1Pmkf/Adam3tm1Pmkf
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000008438 Adam21 / Q9JI76 / Disintegrin and metalloproteinase domain-containing protein 21 / Q9UKJ8* / ADAM metallopeptidase domain 21*  / complex
 ENSMUSG00000028413 P15535 / B4galt1 / Beta-1,4-galactosyltransferase 1 Lactose synthase A protein N-acetyllactosamine synthase Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase Beta-N-acetyl...  / complex / reaction
 ENSMUSG00000043468 Adam30 / a disintegrin and metallopeptidase domain 30 / Q9UKF2* / ADAM metallopeptidase domain 30*  / complex






 

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