| MP:0000266 | abnormal cardiac morphology | "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Sp4tm2Krc/Sp4tm2Krc,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: C57BL/6 * SJL
Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0000267 | abnormal cardiac development | "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370] |
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Allelic Composition: Pax3tm3.1(Pax7)Buck/Pax3Sp
Genetic Background: involves: 129S2/SvPas
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| MP:0000274 | enlarged heart | "increase over normal size of the heart" [J:29971] |
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss
Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0000277 | abnormal heart shape | "malformation of the form or the patterning of the heart" [J:18048] |
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Allelic Composition: Acvr1ctm1Cfi/Acvr1ctm1Cfi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0000278 | abnormal myocardial fiber morphology | "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048] |
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc
Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Txnrd2tm1Marc/Txnrd2tm1.1Marc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Srsf1tm1Xdfu/Srsf1tm1Xdfu
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Tg(Myh6-GFP,MAP2K3)58Ywa/?,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Erbb2tm1Cbm/Erbb2tm2Cbm,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Ptk2tm1.1Guan/Ptk2tm1.1Guan
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL
Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss
Allelic Composition: Mfn2tm1.1Mzhe/Mfn2tm1.1Mzhe,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J
Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0000280 | thin ventricular wall | "decreased depth of the cardiac wall of the heart ventricles" [J:45302] |
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Txnrd2tm1Marc/Txnrd2tm1.1Marc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Srsf1tm1Xdfu/Srsf1tm1Xdfu
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Tg(Myh6-GFP,MAP2K3)58Ywa/?,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Erbb2tm1Cbm/Erbb2tm2Cbm,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor/Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor/Gt(ROSA)26Sor+,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6
Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor/Gt(ROSA)26Sor+,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss
Allelic Composition: Dag1tm2Kcam/Dag1tm2Kcam,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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| MP:0000281 | abnormal ventricular septum morphology | "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S4/SvJae
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| MP:0000343 | altered response to myocardial infarction | "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Axd/Axd+,Grhl3ct/Grhl3+
Genetic Background: involves: BALB/c * C3H/HeN * C57BL/6 * GFF
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| MP:0001544 | abnormal cardiovascular system physiology | "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Rhotm1(EDNRB)Fji/Rho+
Genetic Background: involves: 129S1/Sv * C57BL/6J
Allelic Composition: Tg(Myh6-GFP,MAP2K6)8Ywa/?,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL
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| MP:0001625 | cardiac hypertrophy | "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc
Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Srsf1tm1Xdfu/Srsf1tm1Xdfu
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Erbb2tm1Cbm/Erbb2tm2Cbm,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Ptk2tm1.1Guan/Ptk2tm1.1Guan
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL
Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss
Allelic Composition: Atp1b1tm1.1Akra/Atp1b1tm1.1Akra,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae
Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Vdrtm1.1Sgcg/Vdrtm1.2Sgcg,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL
Allelic Composition: Pak1tm1.1Xwg/Pak1tm1.1Xwg,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0001636 | irregular heartbeat | "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038] |
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL
Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0001785 | edema | "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065] |
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Allelic Composition: Acvr1ctm1Cfi/Acvr1ctm1Cfi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0001855 | atrial thrombosis | "formation or presence of a thrombus in the atria of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae
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| MP:0001954 | respiratory distress | "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931] |
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Allelic Composition: Tg(Myh6-GFP,MAP2K3)58Ywa/?,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Tg(Myh6-GFP,MAP2K6)8Ywa/?,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ube2atm1Agr/Ube2atm1Agr,Ube2btm1Jhjh/Ube2b+
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Srsf1tm1Xdfu/Srsf1tm1Xdfu
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Tg(Myh6-GFP,MAP2K3)58Ywa/?,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Tg(Myh6-GFP,MAP2K6)8Ywa/?,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Erbb2tm1Cbm/Erbb2tm2Cbm,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL
Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss
Allelic Composition: Myl2tm2.1Chen/Myl2tm2.1Chen
Genetic Background: B6.129-Myl2tm2.1Chen
Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0002127 | abnormal cardiovascular system morphology | "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL
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| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Mef2ctm1.1Jjs/Mef2ctm1.1Jjs
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Rxratm1Krc/Rxratm1Krc
Genetic Background: involves: 129S4/SvJae * Black Swiss
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| MP:0002189 | abnormal myocardial trabeculae morphology | "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0002190 | disorganized myocardium | "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044] |
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J
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| MP:0002192 | hydrops fetalis | "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0002740 | heart hypoplasia | "decreased cell number in the heart" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:77765] |
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir,Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: B6.129-Tlr2tm1Kir Tlr4tm1Aki
Allelic Composition: Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor/Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor/Gt(ROSA)26Sor+,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6
Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Fgfr2tm1Dor/Fgfr2tm1Dor,Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor/Gt(ROSA)26Sor+,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0002753 | dilated left ventricle | "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Ptk2tm1.1Guan/Ptk2tm1.1Guan
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL
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| MP:0002754 | dilated right ventricle | "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0002795 | dilated cardiomyopathy | "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Srsf2tm1Xdfu/Srsf2tm1Xdfu
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc
Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Srsf1tm1Xdfu/Srsf1tm1Xdfu
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Erbb2tm1Cbm/Erbb2tm2Cbm,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL
Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss
Allelic Composition: Dag1tm2Kcam/Dag1tm2Kcam,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Myl2tm2.1Chen/Myl2tm2.1Chen
Genetic Background: B6.129-Myl2tm2.1Chen
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| MP:0002833 | increased heart weight | "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission] |
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Allelic Composition: Tg(Myh6-GFP,MAP2K3)58Ywa/?,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Tg(Myh6-GFP,MAP2K6)8Ywa/?,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL
Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss
Allelic Composition: Atp1b1tm1.1Akra/Atp1b1tm1.1Akra,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae
Allelic Composition: Myl2tm2.1Chen/Myl2tm2.1Chen
Genetic Background: B6.129-Myl2tm2.1Chen
Allelic Composition: Pak1tm1.1Xwg/Pak1tm1.1Xwg,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0002837 | dystrophic cardiac calcinosis | "a condition characterized by the localized deposition of calcium salts in the heart; often occuring in association with inflammation or atherosclerotic lesions and other pathological states" [J:76777, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Myl2tm2.1Chen/Myl2tm2.1Chen
Genetic Background: B6.129-Myl2tm2.1Chen
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| MP:0002952 | ventricular cardiomyopathy | "diseases of the ventricles of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0002953 | thick ventricular wall | "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator] |
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Vdrtm1.1Sgcg/Vdrtm1.2Sgcg,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL
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| MP:0002972 | abnormal cardiac muscle contractility | "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Srsf1tm1Xdfu/Srsf1tm1Xdfu
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Atp1b1tm1.1Akra/Atp1b1tm1.1Akra,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae
Allelic Composition: Dag1tm2Kcam/Dag1tm2Kcam,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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| MP:0003021 | abnormal coronary flow rate | "aberrant rate of blood flow in the blood vessels supplying the heart" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission] |
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Allelic Composition: Phexm1Jrt/Y
Genetic Background: B6.129S1-PhexM1Jrt
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| MP:0003038 | decreased infarction size | "decreased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Axd/Axd+,Grhl3ct/Grhl3+
Genetic Background: involves: BALB/c * C3H/HeN * C57BL/6 * GFF
Allelic Composition: Gt(ROSA)26Sortm1(Cdkn1c)Jfpa/Gt(ROSA)26Sor+,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0003137 | abnormal impulse conducting system conduction | "anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:92050, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL
Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0003140 | dilated atria | "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Txnrd2tm1Marc/Txnrd2tm1.1Marc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0003141 | cardiac fibrosis | "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Srsf1tm1Xdfu/Srsf1tm1Xdfu
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL
Allelic Composition: F3tm1Nmk/F3tm1Nmk,Myl2tm1(cre)Krc/?
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac
Allelic Composition: Dag1tm2Kcam/Dag1tm2Kcam,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Allelic Composition: Myl2tm2.1Chen/Myl2tm2.1Chen
Genetic Background: B6.129-Myl2tm2.1Chen
Allelic Composition: Pak1tm1.1Xwg/Pak1tm1.1Xwg,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0003222 | increased cardiomyocyte apoptosis | "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission] |
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Allelic Composition: Pak1tm1.1Xwg/Pak1tm1.1Xwg,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0003223 | decreased cardiomyocyte apoptosis | "decrease in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission] |
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Allelic Composition: Axd/Axd+,Grhl3ct/Grhl3+
Genetic Background: involves: BALB/c * C3H/HeN * C57BL/6 * GFF
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| MP:0003233 | prolonged QT interval | "increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Erbb2tm1Cbm/Erbb2tm2Cbm,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
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| MP:0003828 | pulmonary edema | "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Tg(Myh6-GFP,MAP2K3)58Ywa/?,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Tg(Myh6-GFP,MAP2K6)8Ywa/?,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Pak1tm1.1Xwg/Pak1tm1.1Xwg,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0003915 | increased left ventricle weight | "greater than average weight of the left ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission] |
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Vdrtm1.1Sgcg/Vdrtm1.2Sgcg,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL
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| MP:0003920 | abnormal right ventricle morphology | "structural anomaly of the right lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss
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| MP:0003921 | abnormal left ventricle morphology | "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss
Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0003984 | embryonic growth retardation | "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pax3tm3.1(Pax7)Buck/Pax3Sp
Genetic Background: involves: 129S2/SvPas
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| MP:0004032 | abnormal interventricular groove | "malformation of the intendation dividing the two ventricles, comprised of the sulcus interventricularis anterior and the sulcus interventricularis posterior" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Pax3tm3.1(Pax7)Buck/Pax3Sp
Genetic Background: involves: 129S2/SvPas
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| MP:0004039 | abnormal cardiac cell glucose uptake | "anomalous ability of the cells of the heart to take in glucose" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
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| MP:0004057 | thin myocardial compact layer | "reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Pax3tm3.1(Pax7)Buck/Pax3Sp
Genetic Background: involves: 129S2/SvPas
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| MP:0004076 | abnormal vitelline vascular remodelling | "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Cacnb2tm1Mfre/Cacnb2tm1.1Mfre,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N
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| MP:0004084 | abnormal cardiac muscle relaxation | "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL
Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0004091 | abnormal Z lines | "any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Myl2tm2.1Chen/Myl2tm2.1Chen
Genetic Background: B6.129-Myl2tm2.1Chen
Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0004114 | abnormal atrioventricular node morphology | "structural anomaly in the small nodular mass of specialized muscle fibers located in the interatrial septum near the opening of the coronary sinus; this node gives rise to the electrical connection between the atria and ventricles and responds to the sinoatrial node" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc
Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)
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| MP:0004117 | abnormal atrioventricular bundle morphology | "structural anomaly in the specialized cardiac muscle fibers that originates in the atrioventricular node and extends into the ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc
Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)
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| MP:0004123 | abnormal impulse conducting system morphology | "structural anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc
Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)
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| MP:0004215 | abnormal myocardial fiber physiology | "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Cacnb2tm1Mfre/Cacnb2tm1.1Mfre,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N
Allelic Composition: Atp1b1tm1.1Akra/Atp1b1tm1.1Akra,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae
Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Myl2tm2.1Chen/Myl2tm2.1Chen
Genetic Background: B6.129-Myl2tm2.1Chen
Allelic Composition: Mfn2tm1.1Mzhe/Mfn2tm1.1Mzhe,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J
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| MP:0004485 | increased response of heart to induced stress | "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
Allelic Composition: Atp1b1tm1.1Akra/Atp1b1tm1.1Akra,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae
Allelic Composition: Myl2tm2.1Chen/Myl2tm2.1Chen
Genetic Background: B6.129-Myl2tm2.1Chen
Allelic Composition: Mfn2tm1.1Mzhe/Mfn2tm1.1Mzhe,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J
Allelic Composition: Pak1tm1.1Xwg/Pak1tm1.1Xwg,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0004486 | decreased response of heart to induced stress | "decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir,Tlr4tm1Aki/Tlr4tm1Aki
Genetic Background: B6.129-Tlr2tm1Kir Tlr4tm1Aki
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| MP:0004564 | enlarged myocardial fiber | "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tg(Myh6-GFP,MAP2K6)8Ywa/?,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Myl2tm2.1Chen/Myl2tm2.1Chen
Genetic Background: B6.129-Myl2tm2.1Chen
Allelic Composition: Vdrtm1.1Sgcg/Vdrtm1.2Sgcg,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL
Allelic Composition: Pak1tm1.1Xwg/Pak1tm1.1Xwg,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0004566 | myocardial fiber degeneration | "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dag1tm2Kcam/Dag1tm2Kcam,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
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| MP:0004567 | decreased myocardial fiber number | "decreased number of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0004876 | decreased mean arterial blood pressure | "decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Vdrtm1.1Sgcg/Vdrtm1.2Sgcg,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL
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| MP:0004937 | dilated heart | "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
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| MP:0005140 | decreased cardiac muscle contractility | "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL
Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Pak1tm1.1Xwg/Pak1tm1.1Xwg,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0005294 | abnormal heart ventricle morphology | "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
Allelic Composition: Erbb2tm1Cbm/Erbb2tm2Cbm,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss
Allelic Composition: Vdrtm1.1Sgcg/Vdrtm1.2Sgcg,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL
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| MP:0005329 | abnormal cardiac muscle morphology | "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Ptk2tm1.1Guan/Ptk2tm1.1Guan
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0005333 | decreased heart rate | "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764] |
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Srsf1tm1Xdfu/Srsf1tm1Xdfu
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Cacnb2tm1Mfre/Cacnb2tm1.1Mfre,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N
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| MP:0005464 | abnormal platelet physiology | "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Pip5k1ctm2Csab/Pip5k1ctm2Csab
Genetic Background: Not Specified
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| MP:0005522 | increased circulating atrial natriuretic factor | "greater than the normal concentration of this peptide hormone in the blood; it regulates the water-electrolyte balance and acts as a vasodilator" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Vdrtm1.1Sgcg/Vdrtm1.2Sgcg,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL
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| MP:0005598 | decreased ventricle muscle contractility | "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Srsf2tm1Xdfu/Srsf2tm1Xdfu
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Erbb2tm1Cbm/Erbb2tm2Cbm,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Atp1b1tm1.1Akra/Atp1b1tm1.1Akra,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae
Allelic Composition: Myl2tm2.1Chen/Myl2tm2.1Chen
Genetic Background: B6.129-Myl2tm2.1Chen
Allelic Composition: Mfn2tm1.1Mzhe/Mfn2tm1.1Mzhe,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J
Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0005608 | cardiac interstitial fibrosis | "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Srsf2tm1Xdfu/Srsf2tm1Xdfu
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc
Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)
Allelic Composition: Tg(Myh6-GFP,MAP2K3)58Ywa/?,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Tg(Myh6-GFP,MAP2K6)8Ywa/?,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Ptk2tm1.1Guan/Ptk2tm1.1Guan
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
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| MP:0006035 | abnormal mitochondrial morphology | "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Mfn2tm1.1Mzhe/Mfn2tm1.1Mzhe,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J
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| MP:0006042 | increased apoptosis | "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0006138 | congestive heart failure | "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Txnrd2tm1Marc/Txnrd2tm1.1Marc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL
Allelic Composition: Myl2tm2.1Chen/Myl2tm2.1Chen
Genetic Background: B6.129-Myl2tm2.1Chen
Allelic Composition: Pak1tm1.1Xwg/Pak1tm1.1Xwg,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0006263 | decreased diastolic blood pressure | "abnormal decrease in the pressure in the arteries between heart beats when the heart is relaxed" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887] |
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Allelic Composition: Vdrtm1.1Sgcg/Vdrtm1.2Sgcg,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL
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| MP:0006267 | abnormal intercalated disc morphology | "any structural abnormality in the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:64280] |
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Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL
Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0008022 | dilated heart ventricles | "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myl2tm2.1Chen/Myl2tm2.1Chen
Genetic Background: B6.129-Myl2tm2.1Chen
Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0008028 | pregnancy-related premature death | "death occuring before the normal life span of an organism, occuring during pregnancy, parturition or lactation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Srsf2tm1Xdfu/Srsf2tm1Xdfu
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Slc8a1tm1Kdp/Slc8a1tm1Kdp
Genetic Background: involves: 129S4/SvJae
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| MP:0008260 | abnormal autophagy | "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mfn2tm1.1Mzhe/Mfn2tm1.1Mzhe,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J
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| MP:0008725 | enlarged heart atrium | "increased size of one or both of the two upper chambers of the heart, to which the blood returns from the circulation" [MESH:A07.541.358] |
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
Allelic Composition: Tg(Myh6-GFP,MAP2K3)58Ywa/?,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Tg(Myh6-GFP,MAP2K6)8Ywa/?,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0008842 | lipofuscinosis | "storage in organs of brownish fatty pigment resulting from the breakdown and absorption of damaged blood cells" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mfn2tm1.1Mzhe/Mfn2tm1.1Mzhe,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J
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| MP:0008872 | abnormal response to xenobiotics | "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
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| MP:0008873 | increased sensitivity to xenobiotics | "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae
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| MP:0008874 | decreased sensitivity to xenobiotics | "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Atp1b1tm1.1Akra/Atp1b1tm1.1Akra,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae
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| MP:0008950 | ventricular tachycardia | "paroxysmal rapid beating of the heart originating in an ectopic focus in the heart ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL
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| MP:0009548 | abnormal platelet aggregation | "any functional anomaly in the adhesion of one platelet to one or more other platelets via adhesion molecules" [GO:0070527] |
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Pip5k1ctm2Csab/Pip5k1ctm2Csab
Genetic Background: Not Specified
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| MP:0009732 | ventricular premature beat | "a heartbeat is initiated by abnormal electrical activation originating in the heart ventricles rather than by the sinoatrial node, the normal heartbeat initiator, before a normal heartbeat would occur" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0009763 | increased sensitivity to induced morbidity/mortality | "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae
Allelic Composition: Atp1b1tm1.1Akra/Atp1b1tm1.1Akra,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae
Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0010018 | lung vascular congestion | "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae
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| MP:0010019 | liver vascular congestion | "obstruction of the normal flux of blood within the blood vessel network of the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Txnrd2tm1Marc/Txnrd2tm1.1Marc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0010334 | pleural effusion | "accumulation of excess fluid in the pleural cavity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6
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| MP:0010392 | prolonged QRS complex duration | "increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Erbb4tm1Htig/Erbb4tm1Htig,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0010432 | common ventricle | "the presence of only one working lower chamber in the heart, usually with a virtual absence of the ventricular septum and usually present in conjunction with double inlet left or right ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pax3tm3.1(Pax7)Buck/Pax3Sp
Genetic Background: involves: 129S2/SvPas
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| MP:0010519 | atrioventricular block | "a partial or complete obstruction of the impulse that originates in the atria or sinoatrial node from reaching or transmitting through the atrioventricular node to the ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc
Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)
Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss
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| MP:0010546 | abnormal subendocardium layer morphology | "any structural anomaly of the layer of loose fibrous tissue located between the endocardium and myocardium which contains the nerves and the impulse-conducting system (Purkinje fibers) of the heart" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0010551 | abnormal coronary vessel morphology | "any structural anomaly of any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Egln1tm1.1Brei/Egln1tm1.1Brei,Myl2tm1(cre)Krc/Myl2+
Genetic Background: B6.Cg-Myl2tm1(cre)Krc Egln1tm1.1Brei
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| MP:0010559 | heart block | "a partial or complete obstruction of the propogation of electric impulses through the impulse conduction system of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Vcltm1Ross/Vcltm1Ross
Genetic Background: involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL
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| MP:0010579 | increased heart left ventricle size | "greater than average size of the left ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Myl2tm2.1Chen/Myl2tm2.1Chen
Genetic Background: B6.129-Myl2tm2.1Chen
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| MP:0010636 | bundle branch block | "intraventricular block resulting from an interruption or partial or complete block of conduction in one of the two atrioventricular bundle branches; a prolonged QRS complex seen on an ECG indicates defects in bundle branch conduction; blocks in each branch result in a distinct QRS ECG waveform morphology" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Dsptm1Efu/Dsptm1Efu,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6
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| MP:0010724 | thick interventricular septum | "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Vdrtm1.1Sgcg/Vdrtm1.2Sgcg,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL
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| MP:0010725 | thin interventricular septum | "decreased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ldb3tm4Chen/Ldb3tm4Chen,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss
Allelic Composition: Myl2tm2.1Chen/Myl2tm2.1Chen
Genetic Background: B6.129-Myl2tm2.1Chen
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| MP:0010754 | abnormal heart left ventricle pressure | "any anomaly in the pressure within the left cardiac ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1(Cdkn1c)Jfpa/Gt(ROSA)26Sor+,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
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| MP:0010954 | abnormal cellular respiration | "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333] |
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Allelic Composition: Mfn2tm1.1Mzhe/Mfn2tm1.1Mzhe,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J
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| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Erbb2tm1Cbm/Erbb2tm2Cbm,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
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| MP:0011087 | complete neonatal lethality | "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Txnrd2tm1Marc/Txnrd2tm1.1Marc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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| MP:0011090 | partial perinatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc
Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)
Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd * C57BL
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| MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Amhtm3.1Bhr/Amhtm3.1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
Allelic Composition: Cacnb2tm1Mfre/Cacnb2tm1.1Mfre,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N
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| MP:0011099 | complete lethality throughout fetal growth and development | "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Pax3tm3.1(Pax7)Buck/Pax3Sp
Genetic Background: involves: 129S2/SvPas
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| MP:0011392 | increased fetal cardiomyocyte apoptosis | "increase in the number of fetal cardiomyocytes undergoing programmed cell death" [MGI:csmith] |
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Allelic Composition: Mfn2tm1.1Mzhe/Mfn2tm1.1Mzhe,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J
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