ENSMUSG00000017774


Mus musculus

Features
Gene ID: ENSMUSG00000017774
  
Biological name :Myo1c
  
Synonyms : Myo1c / Q9WTI7 / Unconventional myosin-Ic
  
Possible biological names infered from orthology : myosin IC / O00159
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B5
Gene start: 75650504
Gene end: 75673910
  
Corresponding Affymetrix probe sets: 10378697 (MoGene1.0st)   1419648_at (Mouse Genome 430 2.0 Array)   1419649_s_at (Mouse Genome 430 2.0 Array)   1449550_at (Mouse Genome 430 2.0 Array)   1449551_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121267
Ensembl peptide - ENSMUSP00000099562
Ensembl peptide - ENSMUSP00000099563
Ensembl peptide - ENSMUSP00000070388
Ensembl peptide - ENSMUSP00000104069
NCBI entrez gene - 17913     See in Manteia.
MGI - MGI:106612
RefSeq - XM_006532429
RefSeq - NM_001080774
RefSeq - NM_001080775
RefSeq - NM_008659
RefSeq Peptide - NP_001074244
RefSeq Peptide - NP_032685
RefSeq Peptide - NP_001074243
swissprot - Q5ND45
swissprot - Q9WTI7
Ensembl - ENSMUSG00000017774
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A5PF48ENSDARG00000020924Danio rerio
 myo1cbENSDARG00000061579Danio rerio
 MYO1CENSGALG00000002709Gallus gallus
 MYO1CENSG00000197879Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Myo1h / Q9D6A1 / Unconventional myosin-Ih / Q8N1T3* / myosin IH*ENSMUSG0000006695259
Myo1b / P46735 / myosin IB / O43795*ENSMUSG0000001841743
Myo1a / O88329 / Unconventional myosin-Ia / Q9UBC5* / myosin IA*ENSMUSG0000002540142
Myo1d / Q5SYD0 / Unconventional myosin-Id / O94832* / myosin ID*ENSMUSG0000003544139
Myo1g / Q5SUA5 / Unconventional myosin-Ig / B0I1T2* / myosin IG*ENSMUSG0000002043738
Myo1f / myosin IF / O00160*ENSMUSG0000002430037
Myo1e / E9Q634 / Unconventional myosin-Ie / Q12965* / myosin IE*ENSMUSG0000003222036
Myo15 / Q9QZZ4 / Unconventional myosin-XV / MYO15A* / Q9UKN7* / myosin XVA*ENSMUSG0000004267832
Myo15b / myosin XVBENSMUSG0000003442727


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR001609  Myosin head, motor domain
 IPR010926  Class I myosin tail homology domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036072  Class I myosin, motor domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006605 protein targeting IEA
 biological_processGO:0006612 protein targeting to membrane IEA
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0030050 vesicle transport along actin filament IDA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030838 positive regulation of actin filament polymerization IEA
 biological_processGO:0038089 positive regulation of cell migration by vascular endothelial growth factor signaling pathway IEA
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 biological_processGO:0090314 positive regulation of protein targeting to membrane IEA
 biological_processGO:1900078 positive regulation of cellular response to insulin stimulus IMP
 biological_processGO:1900748 positive regulation of vascular endothelial growth factor signaling pathway IEA
 biological_processGO:2000810 regulation of bicellular tight junction assembly IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005643 nuclear pore IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0005903 brush border IDA
 cellular_componentGO:0009925 basal plasma membrane IEA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0016459 myosin complex IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031941 filamentous actin IEA
 cellular_componentGO:0032420 stereocilium IDA
 cellular_componentGO:0032421 stereocilium bundle IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0045335 phagocytic vesicle IDA
 cellular_componentGO:0060171 stereocilium membrane IEA
 molecular_functionGO:0000146 microfilament motor activity IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0003779 actin binding NAS
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding NAS
 molecular_functionGO:0005524 ATP binding NAS
 molecular_functionGO:0005543 phospholipid binding TAS
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0017160 Ral GTPase binding IEA
 molecular_functionGO:0030898 actin-dependent ATPase activity IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
B-WICH complex positively regulates rRNA expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Car5atm1Sly/Car5atm1Sly,Car5btm1Sly/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000248 macrocytosis "condition in which erythrocytes are larger than normal in size" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Car5atm1Sly/Car5atm1Sly,Car5btm1Sly/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Car5atm1Sly/Car5atm1Sly,Car5btm1Sly/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Car5atm1Sly/Car5atm1Sly,Car5btm1Sly/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004438 abnormal vestibular hair cell physiology "anomalies in processes pertinent to the integrated function of the sensory epithelium of the maculae and cristae in the membranous labyrinth of the inner ear" [J:100987, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Srftm1Rjs/Srftm2.1Nor,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Car5atm1Sly/Car5atm1Sly,Car5btm1Sly/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005642 decreased mean corpuscular hemoglobin concentration "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
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Allelic Composition: Car5atm1Sly/Car5atm1Sly,Car5btm1Sly/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000062825 Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*  / complex / reaction
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / complex
 ENSMUSG00000008859 Rala / P63321 / Ras-related protein Ral-A / P11233* / RAS like proto-oncogene A*  / complex / reaction
 ENSMUSG00000029580 Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*  / complex / reaction






 

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