ENSMUSG00000022683


Mus musculus

Features
Gene ID: ENSMUSG00000022683
  
Biological name :Pla2g10
  
Synonyms : phospholipase A2, group X / Pla2g10 / Q9QXX3
  
Possible biological names infered from orthology : O15496
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: A1
Gene start: 13715057
Gene end: 13730983
  
Corresponding Affymetrix probe sets: 10437804 (MoGene1.0st)   1451502_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023364
Ensembl peptide - ENSMUSP00000111474
NCBI entrez gene - 26565     See in Manteia.
MGI - MGI:1347522
RefSeq - XM_017316987
RefSeq - NM_001291009
RefSeq - NM_011987
RefSeq Peptide - NP_036117
RefSeq Peptide - NP_001277938
swissprot - Q8K130
swissprot - Q9QXX3
Ensembl - ENSMUSG00000022683
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:92162ENSDARG00000099344Danio rerio
 ENSGALG00000019233Gallus gallus
 PLA2G10ENSGALG00000021314Gallus gallus
 O15496ENSG00000069764Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pla2g2a / Mus musculus phospholipase A2, group IIA (platelets, synovial fluid) (Pla2g2a), transcript variant 1, coding, mRNA. / P14555* / phospholipase A2 group IIA*ENSMUSG0000005890836
Q9Z0Y2 / Pla2g1b / Phospholipase A2 / P04054* / phospholipase A2 group IB*ENSMUSG0000002952234
Q9WVF6 / Pla2g2d / phospholipase A2, group IID / Q9UNK4*ENSMUSG0000004120233
Q9QUL3 / Pla2g2e / Group IIE secretory phospholipase A2 / Q9NZK7* / phospholipase A2 group IIE*ENSMUSG0000002875132
Pla2g5 / phospholipase A2, group V / P39877*ENSMUSG0000004119332
Q9QZT4 / Pla2g2f / Group IIF secretory phospholipase A2 / Q9BZM2* / phospholipase A2 group IIF*ENSMUSG0000002874931
Oc90 / Q9Z0L3 / Mus musculus otoconin 90 (Oc90), transcript variant 2, mRNA. / Q02509* / AC100868.1* / otoconin 90*ENSMUSG0000001500128


Protein motifs (from Interpro)
Interpro ID Name
 IPR001211  Phospholipase A2
 IPR016090  Phospholipase A2 domain
 IPR033112  Phospholipase A2, aspartic acid active site
 IPR033113  Phospholipase A2, histidine active site
 IPR036444  Phospholipase A2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006644 phospholipid metabolic process IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0010884 positive regulation of lipid storage IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0032270 positive regulation of cellular protein metabolic process IEA
 biological_processGO:0032308 positive regulation of prostaglandin secretion IEA
 biological_processGO:0042632 cholesterol homeostasis IMP
 biological_processGO:0043030 regulation of macrophage activation IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0050482 arachidonic acid secretion IEA
 biological_processGO:0051977 lysophospholipid transport IEA
 biological_processGO:0090238 positive regulation of arachidonic acid secretion IDA
 biological_processGO:0090370 negative regulation of cholesterol efflux IDA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0004620 phospholipase activity IMP
 molecular_functionGO:0004623 phospholipase A2 activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
 molecular_functionGO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA


Pathways (from Reactome)
Pathway description
Acyl chain remodelling of PC
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Synthesis of PA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5b+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0001744 hypersecretion of cortisol 
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Allelic Composition: Ncor2Gt(RRM275)Byg/Ncor2+
Genetic Background: B6.129P2-Ncor2Gt(RRM275)Byg

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Ncor2Gt(RRM275)Byg/Ncor2+
Genetic Background: B6.129P2-Ncor2Gt(RRM275)Byg

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Afg3l2Emv66/Afg3l2Emv66
Genetic Background: FVB.MEV2-Afg3l2Emv66

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5b+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Afg3l2Emv66/Afg3l2Emv66
Genetic Background: FVB.MEV2-Afg3l2Emv66

 MP:0002972 abnormal cardiac muscle contractility "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5b+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0003038 decreased infarction size "decreased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5b+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0003698 abnormal male reproductive system physiology "anomaly in the function of the male organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pla2g3tm1Murm/Pla2g3+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0004484 altered response of heart to induced stress "change in the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5b+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Afg3l2Emv66/Afg3l2Emv66
Genetic Background: FVB.MEV2-Afg3l2Emv66

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Afg3l2Emv66/Afg3l2Emv66
Genetic Background: FVB.MEV2-Afg3l2Emv66

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Afg3l2Emv66/Afg3l2Emv66
Genetic Background: FVB.MEV2-Afg3l2Emv66

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Afg3l2Emv66/Afg3l2Emv66
Genetic Background: FVB.MEV2-Afg3l2Emv66

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wnt4tm1Amc/Wnt4tm1Amc,Wnt5atm1Amc/Wnt5atm1Amc,Wnt5btm1Tmj/Wnt5b+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Afg3l2Emv66/Afg3l2Emv66
Genetic Background: FVB.MEV2-Afg3l2Emv66

 MP:0009811 abnormal prostaglandin level "anomaly in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Afg3l2Emv66/Afg3l2Emv66
Genetic Background: FVB.MEV2-Afg3l2Emv66

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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