ENSMUSG00000041193


Mus musculus
Pla2g5activityprocessacylchainremodellingresponsedomainacidactivesitelipidmetabolicbiosyntheticregulationerkregionbindingconsumingmyocardialinfarctionmacrophagephysiologydecreasedaspartichistidinesuperfamilyphospholipidplateletactivating

Features
Gene ID: ENSMUSG00000041193
  
Biological name :Pla2g5
  
Synonyms : phospholipase A2, group V / Pla2g5
  
Possible biological names infered from orthology : P39877
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D3
Gene start: 138799244
Gene end: 138863482
  
Corresponding Affymetrix probe sets: 10517655 (MoGene1.0st)   1417814_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030524
Ensembl peptide - ENSMUSP00000099569
Ensembl peptide - ENSMUSP00000099570
Ensembl peptide - ENSMUSP00000099571
NCBI entrez gene - 18784     See in Manteia.
MGI - MGI:101899
RefSeq - XM_017320044
RefSeq - NM_001122954
RefSeq - NM_011110
RefSeq - XM_006538658
RefSeq - XM_011250208
RefSeq - XM_017320043
RefSeq Peptide - NP_035240
RefSeq Peptide - NP_001116426
swissprot - Q6GTW1
Ensembl - ENSMUSG00000041193
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PLA2G5ENSGALG00000018977Gallus gallus
 P39877ENSG00000127472Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pla2g2a / Mus musculus phospholipase A2, group IIA (platelets, synovial fluid) (Pla2g2a), transcript variant 1, coding, mRNA. / P14555* / phospholipase A2 group IIA*ENSMUSG0000005890843
Q9QUL3 / Pla2g2e / Group IIE secretory phospholipase A2 / Q9NZK7* / phospholipase A2 group IIE*ENSMUSG0000002875142
Q9WVF6 / Pla2g2d / phospholipase A2, group IID / Q9UNK4*ENSMUSG0000004120242
Q9QZT4 / Pla2g2f / Group IIF secretory phospholipase A2 / Q9BZM2* / phospholipase A2 group IIF*ENSMUSG0000002874940
Q9QXX3 / Pla2g10 / phospholipase A2, group X / O15496*ENSMUSG0000002268335
Q9Z0Y2 / Pla2g1b / Phospholipase A2 / P04054* / phospholipase A2 group IB*ENSMUSG0000002952233
Oc90 / Q9Z0L3 / Mus musculus otoconin 90 (Oc90), transcript variant 2, mRNA. / Q02509* / AC100868.1* / otoconin 90*ENSMUSG0000001500127


Protein motifs (from Interpro)
Interpro ID Name
 IPR001211  Phospholipase A2
 IPR016090  Phospholipase A2 domain
 IPR033112  Phospholipase A2, aspartic acid active site
 IPR033113  Phospholipase A2, histidine active site
 IPR036444  Phospholipase A2 domain superfamily


Gene Ontology (GO)
primary metabolic processorganic substance metabolic processcellular metabolic processnitrogen compound metabolic processbiosynthetic processregulation of molecular functioncatabolic processsmall molecule metabolic processresponse to chemicalmacromolecule localizationestablishment of localizationcell communicationcellular response to stimulusprimary metabolic processorganic substance metabolic processcellular metabolic processnitrogen compound metabolic processbiosynthetic processregulation of molecular functioncatabolic processsmall molecule metabolic processresponse to chemicalmacromolecule localizationestablishment of localizationcell communicationcellular response to stimulusprimary metabolic processorganic substance metabolic processcellular metabolic processnitrogen compound metabolic processbiosynthetic processregulation of molecular functioncatabolic processsmall molecule metabolic processresponse to chemicalmacromolecule localizationestablishment of localizationcell communicationcellular response to stimulusprimary metabolic processorganic substance metabolic processcellular metabolic processnitrogen compound metabolic processbiosynthetic processregulation of molecular functioncatabolic processsmall molecule metabolic processresponse to chemicalmacromolecule localizationestablishment of localizationcell communicationcellular response to stimulusprimary metabolic processorganic substance metabolic processcellular metabolic processnitrogen compound metabolic processbiosynthetic processregulation of molecular functioncatabolic processsmall molecule metabolic processresponse to chemicalmacromolecule localizationestablishment of localizationcell communicationcellular response to stimulusprimary metabolic processorganic substance metabolic processcellular metabolic processnitrogen compound metabolic processbiosynthetic processregulation of molecular functioncatabolic processsmall molecule metabolic processresponse to chemicalmacromolecule localizationestablishment of localizationcell communicationcellular response to stimulusprimary metabolic processorganic substance metabolic processcellular metabolic processnitrogen compound metabolic processbiosynthetic processregulation of molecular functioncatabolic processsmall molecule metabolic processresponse to chemicalmacromolecule localizationestablishment of localizationcell communicationcellular response to stimulusprimary metabolic processorganic substance metabolic processcellular metabolic processnitrogen compound metabolic processbiosynthetic processregulation of molecular functioncatabolic processsmall molecule metabolic processresponse to chemicalmacromolecule localizationestablishment of localizationcell communicationcellular response to stimulusprimary metabolic processorganic substance metabolic processcellular metabolic processnitrogen compound metabolic processbiosynthetic processregulation of molecular functioncatabolic processsmall molecule metabolic processresponse to chemicalmacromolecule localizationestablishment of localizationcell communicationcellular response to stimulusprimary metabolic processorganic substance metabolic processcellular metabolic processnitrogen compound metabolic processbiosynthetic processregulation of molecular functioncatabolic processsmall molecule metabolic processresponse to chemicalmacromolecule localizationestablishment of localizationcell communicationcellular response to stimulusprimary meprimary metabolic processorganic suorganic substance metabolic processcellular mcellular metabolic processnitrogen cnitrogen compound metabolic processbiosynthetbiosynthetic processregulationregulation of molecular functioncatabolic catabolic processsmall molesmall molecule metabolic processresponse tresponse to chemicalmacromolecmacromolecule localizationestablishmestablishment of localizationcell commucell communicationcellular rcellular response to stimulus
hydrolase activityion bindingcarbohydrate derivative bindingsulfur compound bindinghydrolase activityion bindingcarbohydrate derivative bindingsulfur compound bindinghydrolase activityion bindingcarbohydrate derivative bindingsulfur compound bindinghydrolase activityion bindingcarbohydrate derivative bindingsulfur compound bindinghydrolase activityion bindingcarbohydrate derivative bindingsulfur compound bindinghydrolase activityion bindingcarbohydrate derivative bindingsulfur compound bindinghydrolase activityion bindingcarbohydrate derivative bindingsulfur compound bindinghydrolase activityion bindingcarbohydrate derivative bindingsulfur compound bindinghydrolase activityion bindingcarbohydrate derivative bindingsulfur compound bindinghydrolase activityion bindingcarbohydrate derivative bindingsulfur compound bindinghydrolase activityhydrolase activityion bindingion bindingcarbohydrate derivative bindingcarbohydrate derivative bindingsulfur compound bindingsulfur compound binding
extracellular regioncellorganellemembraneextracellular regioncellorganellemembraneextracellular regioncellorganellemembraneextracellular regioncellorganellemembraneextracellular regioncellorganellemembraneextracellular regioncellorganellemembraneextracellular regioncellorganellemembraneextracellular regioncellorganellemembraneextracellular regioncellorganellemembraneextracellular regioncellorganellemembraneextracellular regionextracellular regioncellcellorganelleorganellemembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006644 phospholipid metabolic process IEA
 biological_processGO:0006663 platelet activating factor biosynthetic process IEA
 biological_processGO:0010518 positive regulation of phospholipase activity IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0019370 leukotriene biosynthetic process IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0050482 arachidonic acid secretion IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004623 phospholipase A2 activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0047498 calcium-dependent phospholipase A2 activity IEA
 molecular_functionGO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
 molecular_functionGO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA


Pathways (from Reactome)
Pathway description
Acyl chain remodelling of PC
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Synthesis of PA


Phenotype (from MGI, Zfin or HPO)
cardiovascular system phenotypehomeostasis/metabolism phenotypeimmune system phenotypehematopoietic system phenotypemuscle phenotypecellular phenotypecardiovascular system phenotypehomeostasis/metabolism phenotypeimmune system phenotypehematopoietic system phenotypemuscle phenotypecellular phenotypecardiovascular system phenotypehomeostasis/metabolism phenotypeimmune system phenotypehematopoietic system phenotypemuscle phenotypecellular phenotypecardiovascular system phenotypehomeostasis/metabolism phenotypeimmune system phenotypehematopoietic system phenotypemuscle phenotypecellular phenotypecardiovascular system phenotypehomeostasis/metabolism phenotypeimmune system phenotypehematopoietic system phenotypemuscle phenotypecellular phenotypecardiovascular system phenotypehomeostasis/metabolism phenotypeimmune system phenotypehematopoietic system phenotypemuscle phenotypecellular phenotypecardiovascular system phenotypehomeostasis/metabolism phenotypeimmune system phenotypehematopoietic system phenotypemuscle phenotypecellular phenotypecardiovascular system phenotypehomeostasis/metabolism phenotypeimmune system phenotypehematopoietic system phenotypemuscle phenotypecellular phenotypecardiovascular system phenotypehomeostasis/metabolism phenotypeimmune system phenotypehematopoietic system phenotypemuscle phenotypecellular phenotypecardiovascular system phenotypehomeostasis/metabolism phenotypeimmune system phenotypehematopoietic system phenotypemuscle phenotypecellular phenotypecardiovascular system pcardiovascular system phenotypehomeostasis/metabolism homeostasis/metabolism phenotypeimmune system phenotypeimmune system phenotypehematopoietic system phhematopoietic system phenotypemuscle phenotypemuscle phenotypecellular phenotypecellular phenotype
IDPhenotypeDefinition Genetic BG
 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Agpat2Gt(OST438470)Lex/Agpat2Gt(OST438470)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nr1h2tm1Djm/Nr1h2tm1Djm,Nr1h3tm1Djm/Nr1h3tm1Djm
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic Background: C.129-Pla2g5tm1Jarm

Allelic Composition: Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic Background: B6.129-Pla2g5tm1Jarm

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002972 abnormal cardiac muscle contractility "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Agpat2Gt(OST438470)Lex/Agpat2Gt(OST438470)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0003038 decreased infarction size "decreased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Agpat2Gt(OST438470)Lex/Agpat2Gt(OST438470)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0003221 abnormal cardiomyocyte apoptosis "change in the timing or the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Agpat2Gt(OST438470)Lex/Agpat2Gt(OST438470)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Agpat2Gt(OST438470)Lex/Agpat2Gt(OST438470)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0005087 reduced acute inflammation "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478]
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Allelic Composition: Amhtm1Bhr/Amh+,Amhr2tm1Bhr/Amhr2tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Agpat2Gt(OST438470)Lex/Agpat2Gt(OST438470)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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