ENSMUSG00000029522


Mus musculus

Features
Gene ID: ENSMUSG00000029522
  
Biological name :Pla2g1b
  
Synonyms : Phospholipase A2 / Pla2g1b / Q9Z0Y2
  
Possible biological names infered from orthology : P04054 / phospholipase A2 group IB
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: F
Gene start: 115466262
Gene end: 115474722
  
Corresponding Affymetrix probe sets: 10524698 (MoGene1.0st)   1416626_at (Mouse Genome 430 2.0 Array)   1433948_at (Mouse Genome 430 2.0 Array)   1433949_x_at (Mouse Genome 430 2.0 Array)   1437015_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107702
Ensembl peptide - ENSMUSP00000138683
Ensembl peptide - ENSMUSP00000120743
Ensembl peptide - ENSMUSP00000031495
NCBI entrez gene - 18778     See in Manteia.
MGI - MGI:101842
RefSeq - NM_011107
RefSeq - XM_006530199
RefSeq Peptide - NP_035237
swissprot - D3Z1N8
swissprot - Q9Z0Y2
swissprot - S4R2K6
swissprot - D3YWH2
Ensembl - ENSMUSG00000029522
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pla2g1bENSDARG00000009153Danio rerio
 ENSGALG00000007236Gallus gallus
 PLA2G1BENSGALG00000020989Gallus gallus
 P04054ENSG00000170890Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pla2g2a / Mus musculus phospholipase A2, group IIA (platelets, synovial fluid) (Pla2g2a), transcript variant 1, coding, mRNA. / P14555* / phospholipase A2 group IIA*ENSMUSG0000005890837
Q9QXX3 / Pla2g10 / phospholipase A2, group X / O15496*ENSMUSG0000002268336
Q9WVF6 / Pla2g2d / phospholipase A2, group IID / Q9UNK4*ENSMUSG0000004120236
Q9QUL3 / Pla2g2e / Group IIE secretory phospholipase A2 / Q9NZK7* / phospholipase A2 group IIE*ENSMUSG0000002875132
Pla2g5 / phospholipase A2, group V / P39877*ENSMUSG0000004119331
Oc90 / Q9Z0L3 / Mus musculus otoconin 90 (Oc90), transcript variant 2, mRNA. / Q02509* / AC100868.1* / otoconin 90*ENSMUSG0000001500128
Q9QZT4 / Pla2g2f / Group IIF secretory phospholipase A2 / Q9BZM2* / phospholipase A2 group IIF*ENSMUSG0000002874925


Protein motifs (from Interpro)
Interpro ID Name
 IPR001211  Phospholipase A2
 IPR016090  Phospholipase A2 domain
 IPR033112  Phospholipase A2, aspartic acid active site
 IPR033113  Phospholipase A2, histidine active site
 IPR036444  Phospholipase A2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002227 innate immune response in mucosa IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006644 phospholipid metabolic process IEA
 biological_processGO:0009395 phospholipid catabolic process TAS
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0019731 antibacterial humoral response IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0046470 phosphatidylcholine metabolic process IEA
 biological_processGO:0050482 arachidonic acid secretion IEA
 biological_processGO:0050830 defense response to Gram-positive bacterium IEA
 biological_processGO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0030141 secretory granule IEA
 molecular_functionGO:0004623 phospholipase A2 activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047498 calcium-dependent phospholipase A2 activity IEA
 molecular_functionGO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
 molecular_functionGO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA


Pathways (from Reactome)
Pathway description
Acyl chain remodelling of PC
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Synthesis of PA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nr3c2tm1Gsc/Nr3c2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Nr3c2tm1Gsc/Nr3c2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nr3c2tm1Gsc/Nr3c2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nr3c2tm1Gsc/Nr3c2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nr3c2tm1Gsc/Nr3c2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Nr3c2tm1Gsc/Nr3c2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nr3c2tm1Gsc/Nr3c2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nr3c2tm1Gsc/Nr3c2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005342 abnormal lipid absorption "anomalous ability of the body to take in fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Nr3c2tm1Gsc/Nr3c2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Nr3c2tm1Gsc/Nr3c2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009289 decreased epididymal fat pad weight 
Show

Allelic Composition: Nr3c2tm1Gsc/Nr3c2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009307 decreased uterine fat pad weight 
Show

Allelic Composition: Nr3c2tm1Gsc/Nr3c2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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