ENSMUSG00000022893


Mus musculus
kidneyAdamts1decreasedpeptidaseactivitybindingreducedmbionthrombospondintype-tsprepeatadamadam-tsmetallopeptidasesuperfamilyovulationovarianureterdilateduterusbodyweightobstructionurinelevelmedullalethalityatrophy

Features
Gene ID: ENSMUSG00000022893
  
Biological name :Adamts1
  
Synonyms : Adamts1 / A disintegrin and metalloproteinase with thrombospondin motifs 1 / P97857
  
Possible biological names infered from orthology : ADAM metallopeptidase with thrombospondin type 1 motif 1 / Q9UHI8
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: C3.3
Gene start: 85793827
Gene end: 85803113
  
Corresponding Affymetrix probe sets: 10440522 (MoGene1.0st)   1450716_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118471
Ensembl peptide - ENSMUSP00000023610
NCBI entrez gene - 11504     See in Manteia.
MGI - MGI:109249
RefSeq - NM_009621
RefSeq Peptide - NP_033751
swissprot - E9PY08
swissprot - P97857
Ensembl - ENSMUSG00000022893
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adamts1ENSDARG00000103519Danio rerio
 ADAMTS1ENSGALG00000040342Gallus gallus
 Q9UHI8ENSG00000154734Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P59384 / Adamts15 / A disintegrin and metalloproteinase with thrombospondin motifs 15 / Q8TE58* / ADAM metallopeptidase with thrombospondin type 1 motif 15*ENSMUSG0000003345348
Adamts8 / A disintegrin and metalloproteinase with thrombospondin motifs 8 isoform 2 / Q9UP79* / ADAM metallopeptidase with thrombospondin type 1 motif 8*ENSMUSG0000003199444
Q8BNJ2 / Adamts4 / A disintegrin and metalloproteinase with thrombospondin motifs 4 / O75173* / ADAM metallopeptidase with thrombospondin type 1 motif 4*ENSMUSG0000000640342
P59511 / Adamts20 / A disintegrin and metalloproteinase with thrombospondin motifs 20 / P59510* / ADAM metallopeptidase with thrombospondin type 1 motif 20*ENSMUSG0000002244939
Q9R001 / Adamts5 / A disintegrin and metalloproteinase with thrombospondin motifs 5 / Q9UNA0* / ADAM metallopeptidase with thrombospondin type 1 motif 5*ENSMUSG0000002289438
Q769J6 / Adamts13 / A disintegrin and metalloproteinase with thrombospondin motifs 13 / Q76LX8* / ADAM metallopeptidase with thrombospondin type 1 motif 13*ENSMUSG0000001485223
Adamts9 / a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 9 / Q9P2N4* / ADAM metallopeptidase with thrombospondin type 1 motif 9*ENSMUSG0000003002218
Papln / Q9EPX2 / Papilin / O95428* / papilin, proteoglycan like sulfated glycoprotein*ENSMUSG0000002122315
Thsd4 / Q3UTY6 / Thrombospondin type-1 domain-containing protein 4 / Q6ZMP0* / thrombospondin type 1 domain containing 4*ENSMUSG0000003228915
Q7TSK7 / Adamtsl2 / ADAMTS-like protein 2 / Q86TH1* / ADAMTS like 2*ENSMUSG0000003604015
Adamtsl3 / ADAMTS-like 3 / P82987*ENSMUSG0000007046915
Q8BLI0 / Adamtsl1 / ADAMTS-like protein 1 / Q8N6G6* / ADAMTS like 1*ENSMUSG0000006611314
Q80T21 / Adamtsl4 / ADAMTS-like protein 4 / Q6UY14* / ADAMTS like 4*ENSMUSG0000001585013


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR002870  Peptidase M12B, propeptide
 IPR006586  ADAM, cysteine-rich
 IPR010294  ADAM-TS Spacer 1
 IPR013274  Peptidase M12B, ADAM-TS1
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
anatomical structure developmentmulticellular organism reproductionnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentmulticellular organism reproductionnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentmulticellular organism reproductionnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentmulticellular organism reproductionnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentmulticellular organism reproductionnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentmulticellular organism reproductionnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentmulticellular organism reproductionnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentmulticellular organism reproductionnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentmulticellular organism reproductionnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developmentmulticellular organism reproductionnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processanatomical structure developanatomical structure developmentmulticellular organism repromulticellular organism reproductionnitrogen compound metabolic nitrogen compound metabolic processprimary metabolic processprimary metabolic processorganic substance metabolic organic substance metabolic process
catalytic activity, acting on a proteinhydrolase activityprotein bindingion bindingcarbohydrate derivative bindingsulfur compound bindingcatalytic activity, acting on a proteinhydrolase activityprotein bindingion bindingcarbohydrate derivative bindingsulfur compound bindingcatalytic activity, acting on a proteinhydrolase activityprotein bindingion bindingcarbohydrate derivative bindingsulfur compound bindingcatalytic activity, acting on a proteinhydrolase activityprotein bindingion bindingcarbohydrate derivative bindingsulfur compound bindingcatalytic activity, acting on a proteinhydrolase activityprotein bindingion bindingcarbohydrate derivative bindingsulfur compound bindingcatalytic activity, acting on a proteinhydrolase activityprotein bindingion bindingcarbohydrate derivative bindingsulfur compound bindingcatalytic activity, acting on a proteinhydrolase activityprotein bindingion bindingcarbohydrate derivative bindingsulfur compound bindingcatalytic activity, acting on a proteinhydrolase activityprotein bindingion bindingcarbohydrate derivative bindingsulfur compound bindingcatalytic activity, acting on a proteinhydrolase activityprotein bindingion bindingcarbohydrate derivative bindingsulfur compound bindingcatalytic activity, acting on a proteinhydrolase activityprotein bindingion bindingcarbohydrate derivative bindingsulfur compound bindingcatalytic activity, actcatalytic activity, acting on a proteinhydrolase activityhydrolase activityprotein bindingprotein bindingion bindingion bindingcarbohydrate derivativecarbohydrate derivative bindingsulfur compound bindingsulfur compound binding
extracellular regioncellorganelleextracellular regioncellorganelleextracellular regioncellorganelleextracellular regioncellorganelleextracellular regioncellorganelleextracellular regioncellorganelleextracellular regioncellorganelleextracellular regioncellorganelleextracellular regioncellorganelleextracellular regioncellorganelleextracellular regionextracellular regioncellcellorganelleorganelle
TypeGO IDTermEv.Code
 biological_processGO:0001542 ovulation from ovarian follicle IMP
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0016525 negative regulation of angiogenesis ISO
 biological_processGO:0060347 heart trabecula formation IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005604 basement membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
O-glycosylation of TSR domain-containing proteins


Phenotype (from MGI, Zfin or HPO)
renal/urinary system phenotypereproductive system phenotypegrowth/size phenotypeendocrine/exocrine gland phenotypehomeostasis/metabolism phenotypeadipose tissue phenotypemortality/agingrenal/urinary system phenotypereproductive system phenotypegrowth/size phenotypeendocrine/exocrine gland phenotypehomeostasis/metabolism phenotypeadipose tissue phenotypemortality/agingrenal/urinary system phenotypereproductive system phenotypegrowth/size phenotypeendocrine/exocrine gland phenotypehomeostasis/metabolism phenotypeadipose tissue phenotypemortality/agingrenal/urinary system phenotypereproductive system phenotypegrowth/size phenotypeendocrine/exocrine gland phenotypehomeostasis/metabolism phenotypeadipose tissue phenotypemortality/agingrenal/urinary system phenotypereproductive system phenotypegrowth/size phenotypeendocrine/exocrine gland phenotypehomeostasis/metabolism phenotypeadipose tissue phenotypemortality/agingrenal/urinary system phenotypereproductive system phenotypegrowth/size phenotypeendocrine/exocrine gland phenotypehomeostasis/metabolism phenotypeadipose tissue phenotypemortality/agingrenal/urinary system phenotypereproductive system phenotypegrowth/size phenotypeendocrine/exocrine gland phenotypehomeostasis/metabolism phenotypeadipose tissue phenotypemortality/agingrenal/urinary system phenotypereproductive system phenotypegrowth/size phenotypeendocrine/exocrine gland phenotypehomeostasis/metabolism phenotypeadipose tissue phenotypemortality/agingrenal/urinary system phenotypereproductive system phenotypegrowth/size phenotypeendocrine/exocrine gland phenotypehomeostasis/metabolism phenotypeadipose tissue phenotypemortality/agingrenal/urinary system phenotypereproductive system phenotypegrowth/size phenotypeendocrine/exocrine gland phenotypehomeostasis/metabolism phenotypeadipose tissue phenotypemortality/agingrenal/urinary systemrenal/urinary system phenotypereproductive system reproductive system phenotypegrowth/size phenotypgrowth/size phenotypeendocrine/exocrine gendocrine/exocrine gland phenotypehomeostasis/metabolihomeostasis/metabolism phenotypeadipose tissue phenoadipose tissue phenotypemortality/agingmortality/aging
IDPhenotypeDefinition Genetic BG
 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Adamts4tm1.1Boer/Adamts4tm1.1Boer
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

Allelic Composition: Adamts1tm1Dgen/Adamts1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000534 abnormal ureter morphology "anomalous structure of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0001123 dilated uterus "stretched or enlarged female muscular organ of gestation" [J:50844]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

 MP:0001729 impaired implantation "impaired ability of the blastocyst to attach to the endometrium of the uterus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Adamts1tm1Mapr/Adamts1tm1Mapr
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Adamts1tm1Mapr/Adamts1tm1Mapr
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: EnamRgsc521/Enam+
Genetic Background: involves: C57BL/6JJcl * DBA/2J

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Adamts1tm1Dgen/Adamts1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002682 reduced number of mature ovarian follicles "fewer than normal numbers of spehroidal cell aggregations in the ovary containing the ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
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Allelic Composition: Adamts1tm1Dgen/Adamts1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003355 reduced ovulation "reduction in the frequency in which an ovum is released from a rupturing ovarian follicle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Adamts1tm1Mapr/Adamts1tm1Mapr
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003587 ureter obstruction "any impediment, blockage, or reversal of the normal flow of the urine towards the bladder" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Adamts1tm1Dgen/Adamts1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005618 decreased potassium excretion "less than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0006317 decreased urine sodium level "lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0008289 abnormal adrenal medulla morphology "any structural anomaly of the inner portion of the adrenal gland that consists mainly of chromaffin cells which produce, store and secrete neurotransmitters such as epinephrine and norepinephrine" [MESH:A06.407.071.265, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0009082 uterus cysts "presence of fluid-filled structures inside the lumen of the uterus; usually refers to benign growths" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Adamts1tm1Mapr/Adamts1tm1Mapr
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Adamts1tm1Mapr/Adamts1tm1Mapr,Adamts4tm1.1Boer/Adamts4tm1.1Boer
Genetic Background: involves: 129 * BALB/cJ * C57BL/6J

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Adamts1tm1Mapr/Adamts1tm1Mapr
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

 MP:0011303 absent kidney papilla "absence of the apex (tip) of a renal pyramid i.e. the location where each medullary pyramid empties urine into a minor calyx" [MGI:anna]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0011305 dilated kidney calyx "an expansion in the lumen volume or area of any of the branches of the renal pelvis that surround each renal papilla and collect urine" [MGI:anna]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Adamts1tm1Mapr/Adamts1tm1Mapr
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011376 abnormal kidney corticomedullary boundary morphology "any structural anomaly of the region demarcating the renal medulla from the surrounding cortex; end-stage renal failure may be associated with loss of the normal corticomedullary boundary" [MGI:anna]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0011422 kidney medulla atrophy "acquired diminution of the size of the inner portion of the kidney consisting of the renal pyramids, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Adamts1tm1Mapr/Adamts1tm1Mapr
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Adamts1tm1Mapr/Adamts1tm1Mapr,Adamts4tm1.1Boer/Adamts4tm1.1Boer
Genetic Background: involves: 129 * BALB/cJ * C57BL/6J

 MP:0011423 kidney cortex atrophy "acquired diminution of the size of the outer portion of the kidney located between the renal capsule and the renal medulla, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Adamts1tm1Mapr/Adamts1tm1Mapr
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Adamts1tm1Dgen/Adamts1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011460 decreased urine chloride ion level "abnormally low amounts of chloride ion in the urine" [MGI:csmith]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0011487 abnormal ureteropelvic junction morphology "any structural anomaly of the junction between the ureter and the renal pelvis of the kidney" [MGI:anna, MGI:csmith]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0011491 ureteropelvic junction obstruction "a partial or total blockage of the flow of urine through the junction of the renal pelvis and the proximal ureter" [MGI:anna]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0011565 kidney papillary hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the apex of the renal pyramid that normally projects into a calyx" [MGI:anna]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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