ENSMUSG00000026737


Mus musculus

Features
Gene ID: ENSMUSG00000026737
  
Biological name :Pip4k2a
  
Synonyms : O70172 / Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha / Pip4k2a
  
Possible biological names infered from orthology : P48426
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A3
Gene start: 18842255
Gene end: 18998126
  
Corresponding Affymetrix probe sets: 10480347 (MoGene1.0st)   1419279_at (Mouse Genome 430 2.0 Array)   1419280_at (Mouse Genome 430 2.0 Array)   1442310_at (Mouse Genome 430 2.0 Array)   1449404_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006912
Ensembl peptide - ENSMUSP00000115475
Ensembl peptide - ENSMUSP00000119075
NCBI entrez gene - 18718     See in Manteia.
MGI - MGI:1298206
RefSeq - XM_006497397
RefSeq - NM_008845
RefSeq - XM_006497394
RefSeq - XM_006497395
RefSeq - XM_006497396
RefSeq Peptide - NP_032871
swissprot - Q544E3
swissprot - F6RJE8
swissprot - A2ASS3
swissprot - O70172
Ensembl - ENSMUSG00000026737
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pip4k2aaENSDARG00000003776Danio rerio
 pip4k2abENSDARG00000063544Danio rerio
 PIP4K2AENSGALG00000007877Gallus gallus
 P48426ENSG00000150867Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q80XI4 / Pip4k2b / Phosphatidylinositol 5-phosphate 4-kinase type-2 beta / P78356*ENSMUSG0000001854778
Q91XU3 / Pip4k2c / Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma / Q8TBX8*ENSMUSG0000002541765
P70182 / Pip5k1a / Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha / Q99755*ENSMUSG0000002812630
O70161 / Pip5k1c / Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma / O60331*ENSMUSG0000003490230
P70181 / Pip5k1b / Phosphatidylinositol 4-phosphate 5-kinase type-1 beta / O14986*ENSMUSG0000002486729
Q6U7H8 / Pip5kl1 / Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 / Q5T9C9* / phosphatidylinositol-4-phosphate 5-kinase like 1*ENSMUSG0000004685421


Protein motifs (from Interpro)
Interpro ID Name
 IPR002498  Phosphatidylinositol-4-phosphate 5-kinase, core
 IPR023610  Phosphatidylinositol-4-phosphate 5-kinase
 IPR027483  Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
 IPR027484  Phosphatidylinositol-4-phosphate 5-kinase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010506 regulation of autophagy IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035855 megakaryocyte development IMP
 biological_processGO:0046488 phosphatidylinositol metabolic process IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:2000786 positive regulation of autophagosome assembly IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005776 autophagosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016307 phosphatidylinositol phosphate kinase activity IEA
 molecular_functionGO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity ISO
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
PI5P Regulates TP53 Acetylation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Synthesis of PIPs in the nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Pip4k2atm1.2Lca/Pip4k2a+,Pip4k2bGt(Betageo)1Lca/Pip4k2bGt(Betageo)1Lca
Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pip4k2atm1.2Lca/Pip4k2a+,Pip4k2bGt(Betageo)1Lca/Pip4k2bGt(Betageo)1Lca
Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pip4k2atm1.2Lca/Pip4k2a+,Pip4k2bGt(Betageo)1Lca/Pip4k2bGt(Betageo)1Lca
Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il9tm1Flv/Il9tm1Flv
Genetic Background: BALB/c-Il9tm1Flv

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Pip4k2bGt(Betageo)1Lca/Pip4k2bGt(Betageo)1Lca,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Pip4k2atm1.2Lca/Pip4k2a+,Pip4k2bGt(Betageo)1Lca/Pip4k2bGt(Betageo)1Lca
Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026737 O70172 / Pip4k2a / Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha / P48426*  / complex
 ENSMUSG00000018547 Q80XI4 / Pip4k2b / Phosphatidylinositol 5-phosphate 4-kinase type-2 beta / P78356*  / complex
 ENSMUSG00000032171 Pin1 / Q9QUR7 / Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 / Q13526* / peptidylprolyl cis/trans isomerase, NIMA-interacting 1*  / complex / reaction
 ENSMUSG00000074997 Pin1rt1 / PIN1* / Q13526* / peptidylprolyl cis/trans isomerase, NIMA-interacting 1*  / complex / reaction
 ENSMUSG00000020623 Map2k6 / P70236 / mitogen-activated protein kinase kinase 6 / P52564*  / reaction
 ENSMUSG00000025417 Q91XU3 / Pip4k2c / Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma / Q8TBX8*  / complex






 

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