ENSDARG00000003776


Danio rerio

Features
Gene ID: ENSDARG00000003776
  
Biological name :pip4k2aa
  
Synonyms : phosphatidylinositol-5-phosphate 4-kinase, type II, alpha a / pip4k2aa
  
Possible biological names infered from orthology : O70172 / P48426 / phosphatidylinositol-5-phosphate 4-kinase type 2 alpha / PIP4K2A
  
Species: Danio rerio
  
Chr. number: 24
Strand: 1
Band:
Gene start: 17068724
Gene end: 17127833
  
Corresponding Affymetrix probe sets: Dr.4478.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000003352
Ensembl peptide - ENSDARP00000153790
NCBI entrez gene - 560360     See in Manteia.
swissprot - B3DJ34
ZFIN ID - ZDB-GENE-080721-18
Ensembl - ENSDARG00000003776
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PIP4K2AENSGALG00000007877Gallus gallus
 P48426ENSG00000150867Homo sapiens
 O70172ENSMUSG00000026737Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pip4k2ab / phosphatidylinositol-5-phosphate 4-kinase, type II, alpha b / O70172* / P48426* / PIP4K2A* / phosphatidylinositol-5-phosphate 4-kinase type 2 alpha*ENSDARG0000006354487
pip4k2ca / phosphatidylinositol-5-phosphate 4-kinase, type II, gamma a / Q8TBX8* / PIP4K2C* / phosphatidylinositol-5-phosphate 4-kinase type 2 gamma*ENSDARG0000003102064
pip4k2cb / phosphatidylinositol-5-phosphate 4-kinase, type II, gamma b / Q8TBX8* / PIP4K2C* / phosphatidylinositol-5-phosphate 4-kinase type 2 gamma*ENSDARG0000009163763
pip5k1cb / phosphatidylinositol-4-phosphate 5-kinase, type I, gamma b / O60331* / O70161* / PIP5K1C* / phosphatidylinositol-4-phosphate 5-kinase type 1 gamma*ENSDARG0000010031332
pip5k1ab / phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b / P70182* / Q99755* / PIP5K1A* / phosphatidylinositol-4-phosphate 5-kinase type 1 alpha*ENSDARG0000002464231
pip5k1ca / phosphatidylinositol-4-phosphate 5-kinase, type I, gamma a / O60331* / O70161* / PIP5K1C* / phosphatidylinositol-4-phosphate 5-kinase type 1 gamma*ENSDARG0000007600131
pip5k1aa / phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a / P70182* / Q99755* / PIP5K1A* / phosphatidylinositol-4-phosphate 5-kinase type 1 alpha*ENSDARG0000010039631
pip5k1bb / phosphatidylinositol-4-phosphate 5-kinase, type I, beta b / O14986* / P70181* / PIP5K1B* / phosphatidylinositol-4-phosphate 5-kinase type 1 beta*ENSDARG0000000650829
pip5k1ba / phosphatidylinositol-4-phosphate 5-kinase, type I, beta a / O14986* / P70181* / PIP5K1B* / phosphatidylinositol-4-phosphate 5-kinase type 1 beta*ENSDARG0000004429529
pip5kl1 / phosphatidylinositol-4-phosphate 5-kinase-like 1 / Q5T9C9* / Q6U7H8* / Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 *ENSDARG0000006094623
si:dkey-3h23.3 / O14986* / P70181* / PIP5K1B* / phosphatidylinositol-4-phosphate 5-kinase type 1 beta*ENSDARG000001048498


Protein motifs (from Interpro)
Interpro ID Name
 IPR002498  Phosphatidylinositol-4-phosphate 5-kinase, core
 IPR023610  Phosphatidylinositol-4-phosphate 5-kinase
 IPR027483  Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
 IPR027484  Phosphatidylinositol-4-phosphate 5-kinase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0046488 phosphatidylinositol metabolic process IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048634 regulation of muscle organ development IMP
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016307 phosphatidylinositol phosphate kinase activity IEA
 molecular_functionGO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity IMP
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
PI5P Regulates TP53 Acetylation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Synthesis of PIPs in the nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000107 eye eye malformed , abnormal
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 ZFA:0000155 somite somite morphology , abnormal
somite skeletal muscle myofibril disorganized , abnormal
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 ZFA:0001094 whole organism whole organism viability , abnormal
whole organism increased curvature , abnormal
whole organism morphology , abnormal
whole organism decreased amount , abnormal
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 ZFA:0001114 head head decreased size , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000003776 pip4k2aa / phosphatidylinositol-5-phosphate 4-kinase, type II, alpha a / O70172* / P48426* / PIP4K2A* / phosphatidylinositol-5-phosphate 4-kinase type 2 alpha*  / complex
 ENSDARG00000063544 pip4k2ab / phosphatidylinositol-5-phosphate 4-kinase, type II, alpha b / O70172* / P48426* / PIP4K2A* / phosphatidylinositol-5-phosphate 4-kinase type 2 alpha*  / complex
 ENSDARG00000091637 pip4k2cb / phosphatidylinositol-5-phosphate 4-kinase, type II, gamma b / Q8TBX8* / PIP4K2C* / phosphatidylinositol-5-phosphate 4-kinase type 2 gamma*  / complex






 

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